Summary: Cytochrome C assembly protein
This is the Wikipedia entry entitled "Cytochrome c assembly protein family". More...
The Wikipedia text that you see displayed here is a download from Wikipedia. This means that the information we display is a copy of the information from the Wikipedia database. The button next to the article title ("Edit Wikipedia article") takes you to the edit page for the article directly within Wikipedia. You should be aware you are not editing our local copy of this information. Any changes that you make to the Wikipedia article will not be displayed here until we next download the article from Wikipedia. We currently download new content on a nightly basis.
Does Pfam agree with the content of the Wikipedia entry ?
Pfam has chosen to link families to Wikipedia articles. In some case we have created or edited these articles but in many other cases we have not made any direct contribution to the content of the article. The Wikipedia community does monitor edits to try to ensure that (a) the quality of article annotation increases, and (b) vandalism is very quickly dealt with. However, we would like to emphasise that Pfam does not curate the Wikipedia entries and we cannot guarantee the accuracy of the information on the Wikipedia page.
Editing Wikipedia articles
Before you edit for the first time
Wikipedia is a free, online encyclopedia. Although anyone can edit or contribute to an article, Wikipedia has some strong editing guidelines and policies, which promote the Wikipedia standard of style and etiquette. Your edits and contributions are more likely to be accepted (and remain) if they are in accordance with this policy.
You should take a few minutes to view the following pages:
How your contribution will be recorded
Anyone can edit a Wikipedia entry. You can do this either as a new user or you can register with Wikipedia and log on. When you click on the "Edit Wikipedia article" button, your browser will direct you to the edit page for this entry in Wikipedia. If you are a registered user and currently logged in, your changes will be recorded under your Wikipedia user name. However, if you are not a registered user or are not logged on, your changes will be logged under your computer's IP address. This has two main implications. Firstly, as a registered Wikipedia user your edits are more likely seen as valuable contribution (although all edits are open to community scrutiny regardless). Secondly, if you edit under an IP address you may be sharing this IP address with other users. If your IP address has previously been blocked (due to being flagged as a source of 'vandalism') your edits will also be blocked. You can find more information on this and creating a user account at Wikipedia.
If you have problems editing a particular page, contact us at firstname.lastname@example.org and we will try to help.
The community annotation is a new facility of the Pfam web site. If you have problems editing or experience problems with these pages please contact us.
Cytochrome c assembly protein family Edit Wikipedia article
|Cytochrome C assembly protein|
In molecular biology, the cytochrome c assembly protein family includes various proteins involved in cytochrome c assembly from mitochondria and bacteria. Members of this family include: CycK from Rhizobium leguminosarum, CcmC from Escherichia coli and Paracoccus denitrificans, and orf240 from Triticum aestivum (Wheat) mitochondria. The members of this family are probably integral membrane proteins with six predicted transmembrane helices that may comprise the membrane component of an ABC (ATP binding cassette) transporter complex. This transporter may be necessary for transport of some component needed for cytochrome c assembly. One member, R. leguminosarum CycK, contains a putative haem-binding motif. Wheat orf240 also contains a putative haem-binding motif and is a proposed ABC transporter with c-type haem as its proposed substrate. However it seems unlikely that all members of this family transport haem or c-type apocytochromes because P. denitrificans CcmC transports neither.
- Delgado MJ, Yeoman KH, Wu G, Vargas C, Davies AE, Poole RK, Johnston AW, Downie JA (September 1995). "Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum". J. Bacteriol. 177 (17): 4927–34. PMC 177267. PMID 7665469.
- Thony-Meyer L, Fischer F, KÃ¼nzler P, Ritz D, Hennecke H (August 1995). "Escherichia coli genes required for cytochrome c maturation". J. Bacteriol. 177 (15): 4321–6. PMC 177179. PMID 7635817.
- Page MD, Pearce DA, Norris HA, Ferguson SJ (February 1997). "The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter". Microbiology (Reading, Engl.) 143 (2): 563–76. doi:10.1099/00221287-143-2-563. PMID 9043133.
- Bonnard G, Grienenberger JM (January 1995). "A gene proposed to encode a transmembrane domain of an ABC transporter is expressed in wheat mitochondria". Mol. Gen. Genet. 246 (1): 91–9. doi:10.1007/bf00290137. PMID 7529870.
Cytochrome C assembly protein Provide feedback
This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from  CcmC from E. coli and Paracoccus denitrificans [2,1] and orf240 from wheat mitochondria . The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an ABC (ATP binding cassette) transporter complex. It is also proposed that this transporter is necessary for transport of some component needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif  orf240 also contains a putative heme-binding motif and is a proposed ABC transporter with c-type heme as its proposed substrate . However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither .
Page D, Pearce DA, Norris HA, Ferguson SJ; , Microbiology 1997;143:563-576.: The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo-c-type cytochrome transporter. PUBMED:9043133 EPMC:9043133
Delgado MJ, Yeoman KH, Wu G, Vargas C, Davies A, Poole RK, Johnston AWB, Downie JA; , J bacteriol 1995;177:4927-4934.: Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum. PUBMED:7665469 EPMC:7665469
External database links
|Transporter classification:||3.A.1 9.B.14|
This tab holds annotation information from the InterPro database.
InterPro entry IPR002541This entry consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium leguminosarum [PUBMED:7665469], CcmC from Escherichia coli and Paracoccus denitrificans [PUBMED:7635817, PUBMED:9043133] and orf240 from Triticum aestivum (Wheat) mitochondria [PUBMED:7529870]. The members of this family are probably integral membrane proteins with six predicted transmembrane helices that may comprise the membrane component of an ABC (ATP binding cassette) transporter complex. This transporter may be necessary for transport of some component needed for cytochrome c assembly.
One member, R. leguminosarum CycK, contains a putative haem-binding motif [PUBMED:7665469]. Wheat orf240 also contains a putative haem-binding motif and is a proposed ABC transporter with c-type haem as its proposed substrate [PUBMED:7529870]. However it seems unlikely that all members of this family transport haem or c-type apocytochromes because P. denitrificans CcmC transports neither [PUBMED:9043133].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Biological process||respiratory chain complex IV assembly (GO:0008535)|
|protein complex assembly (GO:0006461)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Loading domain graphics...
This superfamily includes a variety of different heme binding cytochromes.
The clan contains the following 10 members:COX15-CtaA Cytochrom_B561 Cytochrom_B_N Cytochrom_B_N_2 Cytochrom_C_asm DUF2427 DUF4405 Ferric_reduct Ni_hydr_CYTB PCRF
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- Pfam viewer
- an HTML-based viewer that uses DAS to retrieve alignment fragments on request
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
If you find these logos useful in your own work, please consider citing the following article:
Note: You can also download the data file for the tree.
Curation and family details
|Seed source:||Pfam-B_114 (release 4.1) Pfam-B_8014 (Release 8.0)|
|Author:||Bashton M, Bateman A|
|Number in seed:||39|
|Number in full:||8917|
|Average length of the domain:||196.50 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||51.54 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
Weight segments by...
Change the size of the sunburst
selected sequences to HMM
a FASTA-format file
- 0 sequences
- 0 species
How the sunburst is generated
Colouring and labels
Anomalies in the taxonomy tree
Missing taxonomic levels
Unmapped species names
Too many species/sequences
The tree shows the occurrence of this domain across different species. More...
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree