Summary: T4 recombination endonuclease VII, dimerisation
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T4 recombination endonuclease VII, dimerisation Provide feedback
Members of this family, which are predominantly found in Bacteriophage T4 recombination endonuclease VII, adopt a helical secondary structure, with three alpha helices oriented parallel to each other. They mediate dimerisation of the protein, as well as binding to the DNA major groove .
Raaijmakers H, Toro I, Birkenbihl R, Kemper B, Suck D; , J Mol Biol. 2001;308:311-323.: Conformational flexibility in T4 endonuclease VII revealed by crystallography: implications for substrate binding and cleavage. PUBMED:11327769 EPMC:11327769
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015208
This entry represents a dimerisation domain predominantly found in Bacteriophage T4 recombination endonuclease VII. It adopts a helical secondary structure, with three alpha helices oriented parallel to each other. As well as mediating dimerisation of the protein, this domain is also involved in binding to the DNA major groove [PUBMED:11327769].
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Curation and family details
|Number in seed:||8|
|Number in full:||37|
|Average length of the domain:||53.20 aa|
|Average identity of full alignment:||48 %|
|Average coverage of the sequence by the domain:||34.94 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Endonuc-dimeris domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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