Summary: Stress-induced bacterial acidophilic repeat motif
Stress-induced bacterial acidophilic repeat motif Provide feedback
This repeat is found in proteins which are expressed under conditions of stress in bacteria. The repeat contains a highly conserved, characteristic sequence motif,KGG, that is also recognised by plants and lower eukaryotes and repeated in their LEA (late embryogenesis abundant) family of proteins, thereby rendering those proteins bacteriostatic. An example of such an LEA family is LEA_5, PF00477. Further downstream from this motif is a Walker A, nucleotide binding, motif GXXXXGK(S,T), that in YciG of E coli, eg Q8X7B4 is QSGGNKSGKS [URL]. YciG is expressed as part of a three-gene operon, yciGFE, and this operon is induced by stress and is regulated by RpoS, which controls the general stress-response in E coli. YciG was shown to be important for stationary-phase resistance to thermal stress and in particular to acid stress.
Robbe-Saule V, Lopes MD, Kolb A, Norel F; , J Bacteriol. 2007;189:2976-2987.: Physiological effects of Crl in Salmonella are modulated by sigmaS level and promoter specificity. PUBMED:17293430 EPMC:17293430
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019626
This repeat contains a highly conserved, characteristic sequence motif, KGG, that is recognised by plants and lower eukaryotes. Further downstream from this motif is a Walker A, nucleotide binding motif. YciG is expressed as part of a three-gene operon, yciGFE and this operon is induced by stress and is regulated by RpoS, which controls the general stress-response in E coli. YciG was shown to be important for stationary-phase resistance to thermal stress and in particular to acid stress [PUBMED:17293430].
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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Curation and family details
|Author:||Mistry J, Coggill P|
|Number in seed:||45|
|Number in full:||2185|
|Average length of the domain:||21.90 aa|
|Average identity of full alignment:||59 %|
|Average coverage of the sequence by the domain:||59.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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