Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 32  species 0  interactions 78  sequences 3  architectures

Family: MRFAP1 (PF15155)

Summary: MORF4 family-associated protein1

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "MRFAP1". More...

MRFAP1 Edit Wikipedia article

Morf4 family associated protein 1
Symbols MRFAP1 ; PAM14; PGR1
External IDs MGI3648910 HomoloGene128357 GeneCards: MRFAP1 Gene
Species Human Mouse
Entrez 93621 67568
Ensembl ENSG00000179010 ENSMUSG00000055302
UniProt Q9Y605 Q9CQL7
RefSeq (mRNA) NM_001272053 NM_026242
RefSeq (protein) NP_001258982 NP_080518
Location (UCSC) Chr 4:
6.64 – 6.64 Mb
Chr 5:
36.79 – 36.8 Mb
PubMed search [1] [2]

MORF4 family-associated protein 1 is a protein that in humans is encoded by the MRFAP1 gene.[1][2]


MRFAP1 has been shown to interact with MORF4L1[3][4] and Retinoblastoma protein.[3][4]


  1. ^ Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM (Sep 2004). "PAM14, a Novel MRG- and Rb-Associated Protein, Is Not Required for Development and T-Cell Function in Mice". Mol Cell Biol 24 (19): 8366–73. doi:10.1128/MCB.24.19.8366-8373.2004. PMC 516751. PMID 15367658. 
  2. ^ "Entrez Gene: MRFAP1 Mof4 family associated protein 1". 
  3. ^ a b Leung, J K; Berube N; Venable S; Ahmed S; Timchenko N; Pereira-Smith O M (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". J. Biol. Chem. (United States) 276 (42): 39171–8. doi:10.1074/jbc.M103435200. ISSN 0021-9258. PMID 11500496. 
  4. ^ a b Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". J. Biol. Chem. (United States) 277 (52): 50860–6. doi:10.1074/jbc.M203839200. ISSN 0021-9258. PMID 12397079. 

Further reading

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

MORF4 family-associated protein1 Provide feedback

This family of proteins is found in eukaryotes. Proteins in this family are typically between and 127 amino acids in length.

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR029254

MRFAP1 (MORF4 family-associated protein 1) and its interaction partner MORF4L1 (or MRG15) are target proteins of the NEDD8-cullin pathway, which plays an important role in the degradation of cell cycle regulators and transcriptional control networks. It has been suggest that MRFAP1 competes with MRGBP for binding to MORF4L1, thereby regulating MORF4L1 function in chromatin modification [PUBMED:22038470].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes NCBI
Jalview View  View  View  View  View  View  View   
HTML View  View  View  View  View  View     
PP/heatmap 1 View  View  View  View  View     
Pfam viewer View  View             

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

Representative proteomes NCBI

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

Representative proteomes NCBI
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q9Y605
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 3
Number in full: 78
Average length of the domain: 118.60 aa
Average identity of full alignment: 75 %
Average coverage of the sequence by the domain: 84.33 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 49.1 31.1
Noise cut-off 24.2 24.2
Model length: 119
Family (HMM) version: 2
Download: download the raw HMM for this family

Species distribution

Sunburst controls


Weight segments by...

Change the size of the sunburst


Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls


The tree shows the occurrence of this domain across different species. More...


Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.