Summary: Macoilin family
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Macoilin family Provide feedback
The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons [2-3].
Literature references
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Mirza SP, Halligan BD, Greene AS, Olivier M; , Physiol Genomics. 2007; [Epub ahead of print]: An improved method for the analysis of membrane proteins by mass spectrometry. PUBMED:17341690 EPMC:17341690
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Miyara A, Ohta A, Okochi Y, Tsukada Y, Kuhara A, Mori I;, PLoS Genet. 2011;7:e1001384.: Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans. PUBMED:21589894 EPMC:21589894
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Arellano-Carbajal F, Briseno-Roa L, Couto A, Cheung BH, Labouesse M, de Bono M;, PLoS Genet. 2011;7:e1001341.: Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability. PUBMED:21437263 EPMC:21437263
Internal database links
SCOOP: | AAA_13 ADIP ATG16 BicD bZIP_1 bZIP_2 bZIP_Maf CENP-F_leu_zip Crescentin DMPK_coil EF-hand_4 ERM EzrA Fez1 FPP GAS MAD MFMR_assoc SAM_2 Sec2p Spc7 WH1 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR019130
Macoilin has several highly conserved predicted transmembrane domains towards the N terminus and the coiled-coil regions at the C terminus. It is a conserved nervous system-specific ER membrane protein that regulates neuronal functions [PUBMED:21437263, PUBMED:21589894].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | rough endoplasmic reticulum membrane (GO:0030867) |
Biological process | neuronal signal transduction (GO:0023041) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Alignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (9) |
Full (709) |
Representative proteomes | UniProt (1385) |
NCBI (1732) |
Meta (0) |
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RP15 (142) |
RP35 (277) |
RP55 (531) |
RP75 (755) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
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not generated,
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (9) |
Full (709) |
Representative proteomes | UniProt (1385) |
NCBI (1732) |
Meta (0) |
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RP15 (142) |
RP35 (277) |
RP55 (531) |
RP75 (755) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | KOGs (KOG1821) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
KOGs, Finn RD |
Number in seed: | 9 |
Number in full: | 709 |
Average length of the domain: | 461.10 aa |
Average identity of full alignment: | 36 % |
Average coverage of the sequence by the domain: | 91.54 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 671 | ||||||||||||
Family (HMM) version: | 10 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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