Summary: Mannosyltransferase (PIG-V))
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Mannosyltransferase (PIG-V)) Provide feedback
This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI  .
Kang JY, Hong Y, Ashida H, Shishioh N, Murakami Y, Morita YS, Maeda Y, Kinoshita T; , J Biol Chem 2005;280:9489-9497.: PIG-V Involved in Transferring the Second Mannose in Glycosylphosphatidylinositol. PUBMED:15623507 EPMC:15623507
Fabre AL, Orlean P, Taron CH; , FEBS J 2005;272:1160-1168.: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly. PUBMED:15720390 EPMC:15720390
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007315
This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI [PUBMED:15720390], [PUBMED:15623507].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|endoplasmic reticulum membrane (GO:0005789)|
|Molecular function||transferase activity, transferring hexosyl groups (GO:0016758)|
|Biological process||GPI anchor biosynthetic process (GO:0006506)|
- the number of sequences which exhibit this architecture
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This is the GT-C clan that contains diverse glycosyltransferases that possess 8-13 predicted transmembrane segments .
The clan contains the following 21 members:ALG3 Alg6_Alg8 Arabinose_trans DIE2_ALG10 DUF1420 DUF2029 DUF2079 DUF2142 DUF2723 EpsG Glucan_synthase Glyco_transf_22 Mannosyl_trans Mannosyl_trans2 Oleosin PIG-U PMT PMT_2 PTPS_related STT3 YfhO
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_9248 (release 7.3);|
|Author:||Wood V, Finn RD, Mistry J|
|Number in seed:||4|
|Number in full:||631|
|Average length of the domain:||277.80 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||72.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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