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2  structures 1  species 0  interactions 5  sequences 1  architecture

Family: Metallothio_6 (PF05522)

Summary: Metallothionein

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Metallothionein Edit Wikipedia article

Metallothionein superfamily, eukaryotic
Solution structure of the beta-E-domain of wheat Ec-1 metallothionein.[1]
Symbol Metallothionein_sfam
Pfam PF00131
InterPro IPR003019
PDB 1aoo EBI.jpg
ag-substituted metallothionein from saccharomyces cerevisiae, nmr, minimized average structure
Symbol Yeast_MT
Pfam PF11403
InterPro IPR022710

Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 500 to 14000 Da) proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological (such as zinc, copper, selenium) and xenobiotic (such as cadmium, mercury, silver, arsenic) heavy metals through the thiol group of its cysteine residues, which represent nearly 30% of its constituent amino acid residues.[2]

MT was discovered in 1957 by Vallee and Margoshe from purification of a Cd-binding protein from horse (equine) renal cortex.[3] MTs function is not clear, but experimental data suggest MTs may provide protection against metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress.[4] There are four main isoforms expressed in humans (family 1, see chart below): MT1 (subtypes A, B, E, F, G, H, L, M, X), MT2, MT3, MT4. In the human body, large quantities are synthesised primarily in the liver and kidneys. Their production is dependent on availability of the dietary minerals, as zinc, copper and selenium, and the amino acids histidine and cysteine.

Structure and classification

MTs are present in a vast range of taxonomic groups, ranging from prokaryotes (such as the cyanobacteria Syneccococus spp....), protozoa (p. ex. the ciliate Tetrahymena genera...), plants (such as Pisum sativum, Triticum durum, Zea mays, Quercus suber...), yeast (such as Saccharomyces cerevisiae, Candida albicans,...), invertebrates (such as the nematode Caenorhabditis elegans, the insect Drosophila melanogaster, the mollusc Mytilus edulis, or the echinoderm Strongylocentrotus purpuratus) and vertebrates (such as the chicken, Gallus gallus, or the mammalian Homo sapiens or Mus musculus).

The MTs from this diverse taxonomic range represent a high-heterogeneity sequence (regarding molecular weight and number and distribution of Cys residues) and do not show general homology; in spite of this, homology is found inside some taxonomic groups (such as vertebrate MTs).

From their primary structure, MTs have been classified by different methods. The first one dates from 1987, when Fowler et al., established three classes of MTs: Class I, including the MTs which show homology with horse MT, Class II, including the rest of the MTs with no homology with horse MT, and Class III, which includes phytochelatins, Cys-rich enzymatically synthesised peptides. The second classification was performed by Binz and Kagi in 2001, and takes into account taxonomic parameters and the patterns of distribution of Cys residues along the MT sequence. It results in a classification of 15 families for proteinaceous MTs. Family 15 contains the plant MTs, which in 2002 have been further classified by Cobbet and Goldsbrough into 4 Types (1, 2, 3 and 4) depending on the distribution of their Cys residues and a Cys-devoid regions (called spacers) characteristic of plant MTs.

A table including the principal aspects of the two latter classifications is included.

Family Name Sequence pattern Example
1 Vertebrate K-x(1,2)-C-C-x-C-C-P-x(2)-C M.musculus MT1
2 Molluscan C-x-C-x(3)-C-T-G-x(3)-C-x-C-x(3)-C-x-C-K M.edulis 10MTIV
3 Crustacean P-[GD)-P-C-C-x(3,4)-C-x-C H.americanus MTH
4 Echinoderms P-D-x-K-C-[V,F)-C-C-x(5)-C-x-C-x(4)-


S.purpuratus SpMTA
5 Diptera C-G-x(2)-C-x-C-x(2)-Q-x(5)-C-x-C-x(2)D-C-x-C D.melanogaster MTNB
6 Nematoda K-C-C-x(3)-C-C C.elegans MT1
7 Ciliate x-C-C-C-x ? T.termophila MTT1
8 Fungal 1 C-G-C-S-x(4)-C-x-C-x(3,4)-C-x-C-S-x-C N.crassa MT
9 Fungal 2 --- C.glabrata MT2
10 Fungal 3 --- C.glabrata MT2
11 Fungal 4 C-X-K-C-x-C-x(2)-C-K-C Y.lipolitica MT3
12 Fungal 5 --- S.cerevisiae CUP1
13 Fungal 6 --- S.cerevisiae CRS5
14 Procaryota K-C-A-C-x(2)-C-L-C Synechococcus sp SmtA
15 Plant
15.1 Plant MTs Type 1 C-X-C-X(3)- C-X-C-X(3)- C-X-C-X(3)-spacer-C-X-C-X(3)- C-X-C-X(3)- C-X-C-X(3) Pisum sativum MT
15.2 Plant MTs Type 2 C-C-X(3)-C-X-C-X(3)- C-X-C-X(3)- C-X-C-X(3)-spacer- C-X-C-X(3)- C-X-C-X(3)- C-X-C-X(3) L.esculetum MT
15.3 Plant MTs Type 3 --- A.thaliana MT3
15.4 Plant MTs Type 4 or Ec C-x(4)-C-X-C-X(3)-C-X(5)-C-X-C-X(9,11)-HTTCGCGEHC-


T.aestium MT
99 Phytochelatins and other non-proteinaceous MT-like polypeptides --- S.pombe

More data on this classification are discoverable at the Expasy metallothionein page.[5]

Secondary structure elements have been observed in several MTs SmtA from Syneccochoccus, mammalian MT3, Echinoderma SpMTA, fish Notothenia Coriiceps MT, Crustacean MTH, but until this moment, the content of such structures is considered to be poor in MTs, and its functional influence is not considered.

Tertiary structure of MTs is also highly heterogeneous. While vertebrate, echinoderm and crustacean MTs show a bidominial structure with divalent metals as Zn(II) or Cd(II) (the protein is folded so as to bind metals in two functionally independent domains, with a metallic cluster each), yeast and procariotyc MTs show a monodominial structure (one domain with a single metallic cluster). Although no structural data is available for molluscan, nematoda and Drosophila MTs, it is commonly assumed that the former are bidominial and the latter monodominial. No conclusive data are available for Plant MTs, but two possible structures have been proposed: 1) a bidominial structure similar to that of vertebrate MTs; 2) a codominial structure, in which two Cys-rich domains interact to form a single metallic cluster.

Quaternary structure has not been broadly considered for MTs. Dimerization and oligomerization processes have been observed and attributed to several molecular mechanisms, including intermolecular disulfide formation, bridging through metals bound by either Cys or His residues on different MTs, or inorganic phosphate-mediated interactions. Dimeric and polymeric MTs have been shown to acquire novel properties upon metal detoxification, but the physiological significance of these processes has been demonstrated only in the case of prokaryotic Synechococcus SmtA. The MT dimer produced by this organism forms structures similar to zinc fingers and has Zn-regulatory activity.

Metallothioneins have diverse metal-binding preferences, which have been associated with functional specificity. As an example, the mammalian Mus musculus MT1 preferentially binds divalent metal ions (Zn(II), Cd(II),...), while yeast CUP1 is selective for monovalent metal ions (Cu(I), Ag(I),...). Strictly metal-selective MTs with metal-specific physiological functions were discovered by Dallinger et al. (1997) in pulmonate snails (Gastropoda, Mollusca).[6] The Roman snail (Helix pomatia), for example, possesses a Cd-selective (CdMT) and a Cu-selective isoform (CuMT) involved in Cd detoxification and Cu regulation, respectively.[6] While both isoforms contain unvaried numbers and positions of Cys residues responsible for metal ligation, metal selectivity is apparently achieved by sequence modulation of amino acid residues not directly involved in metal binding (Palacios et al. 2011).[6][7]

A novel functional classification of MTs as Zn- or Cu-thioneins is currently being developed based on these functional preferences.


Metallothioneins are characterised by an abundance of cysteine residues and a lack of generic secondary structure motifs. Yeast Metallothionein (MT) are also alternatively named, Copper metallothionein (CUP).


This protein functions in primary metal storage, transport and detoxification.[8] More specifically, Yeast MT stores copper so therefore protects the cell against copper toxicity by tightly chelating copper ions.


For the first 40 residues in the protein the polypeptide wraps around the metal by forming two large parallel loops separated by a deep cleft containing the metal cluster.[8]


Yeast MT can be found in the following:[9]

  • Saccharomyces cerevisiae
  • Neurospora crassa


Metal binding

Metallothionein has been documented to bind a wide range of metals including cadmium,[10] zinc, mercury, copper, arsenic, silver, etc. Metallation of MT was previously reported to occur cooperatively but recent reports have provided strong evidence that metal-binding occurs via a sequential, noncooperative mechanism.[11] The observation of partially metallated MT (that is, having some free metal binding capacity) suggest that these species are biologically important.

Metallothioneins likely participate in the uptake, transport, and regulation of zinc in biological systems. Mammalian MT binds three Zn(II) ions in its beta domain and four in the alpha domain. Cysteine is a sulfur-containing amino acid, hence the name "-thionein". However, the participation of inorganic sulfide and chloride ions has been proposed for some MT forms. In some MTs, mostly bacterial, histidine participates in zinc binding. By binding and releasing zinc, metallothioneins (MTs) may regulate zinc levels within the body. Zinc, in turn, is a key element for the activation and binding of certain transcription factors through its participation in the zinc finger region of the protein.[12][13] Metallothionein also carries zinc ions (signals) from one part of the cell to another. When zinc enters a cell, it can be picked up by thionein (which thus becomes "metallothionein") and carried to another part of the cell where it is released to another organelle or protein. In this way the thionein-metallothionein becomes a key component of the zinc signaling system in cells. This system is particularly important in the brain, where zinc signaling is prominent both between and within nerve cells. It also seems to be important for the regulation of the tumor suppressor protein p53.

Control of oxidative stress

Cysteine residues from MTs can capture harmful oxidant radicals like the superoxide and hydroxyl radicals.[14] In this reaction, cysteine is oxidized to cystine, and the metal ions which were bound to cysteine are liberated to the media. As explained in the Expression and regulation section, this Zn can activate the synthesis of more MTs. This mechanism has been proposed to be an important mechanism in the control of the oxidative stress by MTs. The role of MTs in oxidative stress has been confirmed by MT Knockout mutants, but some experiments propose also a prooxidant role for MTs.

Expression and regulation

Metallothionein gene expression is induced by a high variety of stimuli, as metal exposure, oxidative stress, glucocorticoids, hydric stress, etc. The level of the response to these inducers depends on the MT gene. MT genes present in their promotors specific sequences for the regulation of the expression, elements as metal response elements (MRE), glucocorticoid response elements (GRE), GC-rich boxes, basal level elements (BLE), and thyroid response elements (TRE).[15]

Metallothionein and disease


Because MTs play an important role in transcription factor regulation, problems with MT function or expression may lead to malignant transformation of cells and ultimately cancer.[16] Studies have found increased expression of MTs in some cancers of the breast, colon, kidney, liver, skin (melanoma), lung, nasopharynx, ovary, prostate, mouth, salivary gland, testes, thyroid and urinary bladder; they have also found lower levels of MT expression in hepatocellular carcinoma and liver adenocarcinoma.[17]

There is evidence to suggest that higher levels of MT expression may also lead to resistance to chemotherapeutic drugs.[18]


Heavy metal toxicity has been proposed as a hypothetical etiology of autism, and dysfunction of MT synthesis and activity may play a role in this. Many heavy metals, including mercury, lead, and arsenic have been linked to symptoms that resemble the neurological symptoms of autism.[19] However, MT dysfunction has not specifically been linked to autistic spectrum disorders. A 2006 study, investigating children exposed to the vaccine preservative thiomersal, found that levels of MT and antibodies to MT in autistic children did not differ significantly from non-autistic children.[20]

A low zinc to copper ratio has been seen as a biomarker for autism and suggested as an indication that the Metallothionein system has been affected.[21]

And further there is indication that the mothers zinc levels may affect the developing babies immunological state that may lead to autism and could be again an indication that the Metallothionein system has been affected [22]

See also


  1. ^ PDB: 2KAK​; Peroza EA, Schmucki R, Güntert P, Freisinger E, Zerbe O (March 2009). "The beta(E)-domain of wheat E(c)-1 metallothionein: a metal-binding domain with a distinctive structure". J. Mol. Biol. 387 (1): 207–18. doi:10.1016/j.jmb.2009.01.035. PMID 19361445. 
  2. ^ Sigel H, Sigel A, eds. (2009). Metallothioneins and Related Chelators (Metal Ions in Life Sciences). Metal Ions in Life Sciences 5. Cambridge, England: Royal Society of Chemistry. ISBN 1-84755-899-2. 
  3. ^ Margoshes M, Vallee BL (1957). "A cadmium protein from equine kidney cortex". Journal of the American Chemical Society 79 (17): 4813–4814. doi:10.1021/ja01574a064. 
  4. ^ Felizola SJ, Nakamura Y, Arata Y, Ise K, Satoh F, Rainey WE, Midorikawa S, Suzuki S, Sasano H (2014). "Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders". Endocrine Pathology 25 (3): 229–235. doi:10.1007/s12022-013-9280-9. PMID 24242700. 
  5. ^ "Metallothioneins: classification and list of entries". 
  6. ^ a b c Dallinger R, Berger B, Hunziker P, Kägi JH (1997). "Metallothionein in snail Cd and Cu metabolism". Nature 388 (6639): 237–238. 
  7. ^ Palacios Ò, Pagani A, Pérez-Rafael S, Egg M, Höckner M, Brandstätter A, Capdevila M, Atrian S, Dallinger R (2011). "Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: evolutionary differentiation of mollusc metallothioneins". BMC Biology 9 (4): 1–20. 
  8. ^ a b Peterson CW, Narula SS, Armitage IM (January 1996). "3D solution structure of copper and silver-substituted yeast metallothioneins". FEBS Lett. 379 (1): 85–93. doi:10.1016/0014-5793(95)01492-6. PMID 8566237. 
  9. ^ Butt TR, Ecker DJ (September 1987). "Yeast metallothionein and applications in biotechnology". Microbiol. Rev. 51 (3): 351–64. PMC 373116. PMID 3312986. 
  10. ^ Freisinger E, Vašák M (2013). "Cadmium in metallothioneins". Met Ions Life Sci 11: 339–71. doi:10.1007/978-94-007-5179-8_11. PMID 23430778. 
  11. ^ Krezel A, Maret W (September 2007). "Dual nanomolar and picomolar Zn(II) binding properties of metallothionein". J. Am. Chem. Soc. 129 (35): 10911–21. doi:10.1021/ja071979s. PMID 17696343. 
  12. ^ Huang M, Krepkiy D, Hu W, Petering D (2004). "Zn-, Cd-, and Pb-transcription factor IIIA: properties, DNA binding, and comparison with TFIIIA-finger 3 metal complexes". Journal of Inorganic Biochemistry 98 (5): 775–785. doi:10.1016/j.jinorgbio.2004.01.014. PMID 15134923. 
  13. ^ Huang M, Shaw CF, Petering D (2004). "Interprotein metal exchange between transcription factor IIIa and apo-metallothionein". Journal of Inorganic Biochemistry 98 (4): 639–648. doi:10.1016/j.jinorgbio.2004.02.004. PMID 15041244. 
  14. ^ Kumari MV, Hiramatsu M, Ebadi M (August 1998). "Free radical scavenging actions of metallothionein isoforms I and II". Free Radic. Res. 29 (2): 93–101. doi:10.1080/10715769800300111. PMID 9790511. 
  15. ^ Klaassen, C; Liu, J; Choudhuri, S (1999). "Metallothionein: an intracellular protein to protect against cadmium toxicity". Annual Review of Pharmacology and Toxicology 39: 267–294. doi:10.1146/annurev.pharmtox.39.1.267. PMID 10331085. 
  16. ^ Krizkova S, Fabrik I, Adam V, Hrabeta J, Eckschlager T, Kizek R (2009). "Metallothionein--a promising tool for cancer diagnostics". Bratisl Lek Listy 110 (2): 93–7. PMID 19408840. 
  17. ^ Cherian, M. (2003). "Metallothioneins in human tumors and potential roles in carcinogenesis". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 533: 201–209. doi:10.1016/j.mrfmmm.2003.07.013. PMID 14643421. 
  18. ^ Basu, A. (2010). "Cellular Responses to Cisplatin-Induced DNA Damage". Journal of Nucleic Acids 2010. doi:10.4061/2010/201367. 
  19. ^ Drum DA (October 2009). "Are toxic biometals destroying your children's future?". Biometals 22 (5): 697–700. doi:10.1007/s10534-009-9212-9. PMID 19205900. 
  20. ^ Singh VK, Hanson J (June 2006). "Assessment of metallothionein and antibodies to metallothionein in normal and autistic children having exposure to vaccine-derived thimerosal". Pediatr Allergy Immunol 17 (4): 291–6. doi:10.1111/j.1399-3038.2005.00348.x. PMID 16771783. 
  21. ^ Faber, S (2009). "The plasma zinc/serum copper ratio as a biomarker in children". Biomarkers 14: 171–80. doi:10.1080/13547500902783747. PMID 19280374. 
  22. ^ Guillermo, Vela (2015). "Zinc in Gut-Brain Interaction in Autism". Neural Plast. 2015: 972791. doi:10.1155/2015/972791. PMC 4386645. PMID 25878905. 

Further reading

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This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Metallothionein Provide feedback

This family consists of metallothioneins from several worm and sea urchin species. Metallothioneins are low molecular weight, cysteine rich proteins known to be involved in heavy metal detoxification and homeostasis [1].

Literature references

  1. Sturzenbaum SR, Kille P, Morgan AJ; , FEBS Lett 1998;431:437-442.: The identification, cloning and characterization of earthworm metallothionein. PUBMED:9714559 EPMC:9714559

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR017980

Metallothioneins (MT) are small proteins that bind heavy metals, such as zinc, copper, cadmium, nickel, etc. They have a high content of cysteine residues that bind the metal ions through clusters of thiolate bonds [PUBMED:1779825, PUBMED:2959513]. An empirical classification into three classes has been proposed by Fowler and coworkers [PUBMED:2959504] and Kojima [PUBMED:1779826]. Members of class I are defined to include polypeptides related in the positions of their cysteines to equine MT-1B, and include mammalian MTs as well as from crustaceans and molluscs. Class II groups MTs from a variety of species, including sea urchins, fungi, insects and cyanobacteria. Class III MTs are atypical polypeptides composed of gamma-glutamylcysteinyl units [PUBMED:2959504].

This original classification system has been found to be limited, in the sense that it does not allow clear differentiation of patterns of structural similarities, either between or within classes. Consequently, all class I and class II MTs (the proteinaceous sequences) have now been grouped into families of phylogenetically-related and thus alignable sequences. This system subdivides the MT superfamily into families, subfamilies, subgroups, and isolated isoforms and alleles.

The metallothionein superfamily comprises all polypeptides that resemble equine renal metallothionein in several respects [PUBMED:2959504]: e.g., low molecular weight; high metal content; amino acid composition with high Cys and low aromatic residue content; unique sequence with characteristic distribution of cysteines, and spectroscopic manifestations indicative of metal thiolate clusters. A MT family subsumes MTs that share particular sequence-specific features and are thought to be evolutionarily related. The inclusion of a MT within a family presupposes that its amino acid sequence is alignable with that of all members. Fifteen MT families have been characterised, each family being identified by its number and its taxonomic range.

Echinoidea (sea urchin, family 4) MTs are 64-67 residue proteins. Members of this family are recognised by the sequence pattern P-D-x-K-C-[V,F]-C-C-x(5)-C-x-C-x(4)-C-C-x(4)-C-C-x(4,6)-C-C located near the N terminus. The taxonomic range of the members extends to sea urchins (echinodea). The protein sequence is divided into two structural domains, each containing 9 and 11 Cys residues binding 3 and 4 bivalent metal ions, respectively. Family 4 includes subfamilies: e1, e2, they are separate phylogenetic groups.

This entry includes the sea urchin proteins, and related sequences from worms.

Domain organisation

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Pfam Clan

This family is a member of clan Metallothionein (CL0461), which has the following description:

This superfamily contains related families of metallothioneins, prokaryotes and eukaryotes.

The clan contains the following 6 members:

Metallothi_Euk2 Metallothio Metallothio_6 Metallothio_Euk Metallothio_Pro Yeast_MT


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Seed source: Pfam-B_1360 (release 8.0)
Previous IDs: Metallothionein;
Type: Family
Author: Moxon SJ
Number in seed: 7
Number in full: 5
Average length of the domain: 63.80 aa
Average identity of full alignment: 86 %
Average coverage of the sequence by the domain: 98.46 %

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HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.9 20.9
Trusted cut-off 60.1 60.0
Noise cut-off 16.9 16.0
Model length: 65
Family (HMM) version: 8
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Species distribution

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Archea Archea Eukaryota Eukaryota
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Metallothio_6 domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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