Summary: Myosin tail
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Myosin tail Provide feedback
The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types [1]. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament [1]. The coiled-coil region provides the structural backbone the thick filament [1].
Literature references
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Strehler EE, Strehler-page M-A, Perriard JC, Periasamy M, Nadal-ginard B; , J MOL BIOL 1986;190:291-317.: Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene. Evidence against intron-dependent evolution of the rod. PUBMED:3783701 EPMC:3783701
Internal database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002928
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains [PUBMED:1939027], 2 alkali light chains, and 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail, although some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains, coded for by a multi-gene family [PUBMED:2806546]. Myosin interacts with actin to convert chemical energy, in the form of ATP, to mechanical energy [PUBMED:3540939]. The 3-D structure of the head portion of myosin has been determined [PUBMED:8316857] and a model for actin-myosin complex has been constructed [PUBMED:8316858].
This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament [PUBMED:3783701]. The coiled-coil region provides the structural backbone of the thick filament [PUBMED:3783701].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | myosin complex (GO:0016459) |
Molecular function | motor activity (GO:0003774) |
Domain organisation
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Alignments
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Seed (13) |
Full (7786) |
Representative proteomes | UniProt (14545) |
NCBI (25344) |
Meta (12) |
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RP15 (1053) |
RP35 (2626) |
RP55 (5903) |
RP75 (8454) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (13) |
Full (7786) |
Representative proteomes | UniProt (14545) |
NCBI (25344) |
Meta (12) |
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RP15 (1053) |
RP35 (2626) |
RP55 (5903) |
RP75 (8454) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
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Curation and family details
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Curation
Seed source: | Pfam-B_356 (release 4.1) |
Previous IDs: | Myosin_tail; |
Type: | Coiled-coil |
Sequence Ontology: | SO:0001080 |
Author: |
Bashton M |
Number in seed: | 13 |
Number in full: | 7786 |
Average length of the domain: | 713.40 aa |
Average identity of full alignment: | 33 % |
Average coverage of the sequence by the domain: | 51.25 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 1081 | ||||||||||||
Family (HMM) version: | 20 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Myosin_tail_1 domain has been found. There are 77 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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