Summary: Prokaryotic N-terminal methylation motif
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Prokaryotic N-terminal methylation motif Provide feedback
This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see PF00114 PF05946 PF02501 and PF07596.
Internal database links
|SCOOP:||DUF2614 PulG N_methyl_2 N_methyl_3|
|Similarity to PfamA using HHSearch:||N_methyl_2 N_methyl_3|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012902
This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N terminus of pilins and other proteins involved in secretion (see INTERPRO, INTERPRO, INTERPRO and INTERPRO).
There is a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue produced after cleavage, usually Phe, is methylated. Separate domains of the prepilin peptidase appear to be responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this region.
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This is a clan contains bacterial pilus subunits and proteins involved in secretion. Pili proteins enable the transfer of plasmid between bacteria. The families in this clan adopt an alpha helical structure which is packed against a beta sheet [2-3].
The clan contains the following 11 members:Bundlin ComP_DUS N_methyl N_methyl_2 N_methyl_3 Pilin PilS T2SSG T2SSI TcpA YadA_anchor
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Curation and family details
|Seed source:||Pfam-B_6484 (release 14.0)|
|Number in seed:||60|
|Number in full:||14824|
|Average length of the domain:||20.00 aa|
|Average identity of full alignment:||52 %|
|Average coverage of the sequence by the domain:||13.02 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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