Summary: Nitrogenase component 1 type Oxidoreductase
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Nitrogenase component 1 type Oxidoreductase Provide feedback
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Internal database links
|SCOOP:||CPSase_L_chain AdoHcyase_NAD RtcB Mur_ligase Peripla_BP_2 NYN_YacP MMR1 F-112 ETRAMP DUF2529 DUF3491 CoA_binding_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000510Enzymes belonging to this family include cofactor-requiring nitrogenases and protochlorophyllide reductase. The key enzymatic reactions in nitrogen fixation are catalysed by the nitrogenase complex, which has two components, the iron protein (component 2), and a component (component 1) which is either a molybdenum-iron, vanadium-iron or iron-iron protein. The enzyme (EC) forms a hexamer of two alpha, two beta and two delta chains. Protochlorophyllide reductase (EC) is involved in the light-dependent accumulation of chlorophyll, probably at the step of reduction of protochlorophyllide to chlorophyllide.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||oxidoreductase activity (GO:0016491)|
|Biological process||oxidation-reduction process (GO:0055114)|
- the number of sequences which exhibit this architecture
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This superfamily is characterised by a long alpha helical insertion in the interdomain linker in the Chelatase-like fold. Representative families include the periplasmic ferric siderophore binding proteins, the TroA-like nitrogenase iron-molybdenum proteins and the putative iron(III) transporter family, TM0189-like, or periplasmic-binding family.
The clan contains the following 2 members:Oxidored_nitro Peripla_BP_2
We make a range of alignments for each Pfam-A family:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Number in seed:||80|
|Number in full:||6347|
|Average length of the domain:||355.90 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||84.23 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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There are 5 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Oxidored_nitro domain has been found. There are 146 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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