Summary: PAN domain
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The PAN domain  contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.
Tordai H, Banyai L, Patthy L; , FEBS Lett 1999;461:63-67.: The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins. PUBMED:10561497 EPMC:10561497
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003014
PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions [PUBMED:10561497]. These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs
It has been shown that, the N-terminal N domains of members of the plasminogen/hepatocyte growth factor family, the apple domains of the plasma prekallikrein/coagulation factor XI family, and domains of various nematode proteins belong to the same module superfamily, the PAN module [PUBMED:10561497]. PAN contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge that links the N and C termini of the domain.
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PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions . These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs.
The clan contains the following 4 members:PAN_1 PAN_2 PAN_3 PAN_4
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Patthy L|
|Previous IDs:||apple; Apple;PAN;|
|Number in seed:||89|
|Number in full:||2217|
|Average length of the domain:||80.20 aa|
|Average identity of full alignment:||16 %|
|Average coverage of the sequence by the domain:||20.08 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||21|
|Download:||download the raw HMM for this family|
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There are 3 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PAN_1 domain has been found. There are 64 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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