Summary: PELOTA RNA binding domain
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PELOTA RNA binding domain Provide feedback
This RNA binding Pelota domain  is at the C-terminus of a PRTase family . These PRTase+Pelota genes are found in the biosynthetic operon associated with the Ter stress-response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response .
Anantharaman V, Iyer LM, Aravind L;, Mol Biosyst. 2012;8:3142-3165.: Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing. PUBMED:23044854 EPMC:23044854
This tab holds annotation information from the InterPro database.
InterPro entry IPR028157
This RNA-binding PELOTA domain [PUBMED:11917006] is at the C terminus of a phosphoribosyltransferase (PRTase) family [PUBMED:23044854]. These PRTase+Pelota genes are found in the biosynthetic operon associated with the Ter stress response operon, and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response [PUBMED:23044854]. However, at least one protein predicted to possess this domain (SWISSPROT) has been shown to posses cysteine protease activity [PUBMED:24206355].
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The members of this clan are all involved in binding to ribose sugar of RNA. Indeed, the key RNA binding residues are conserved across the different families . Members of this clan form mixed alpha-helical and beta-sheet structures .
The clan contains the following 5 members:eRF1_3 PELOTA_1 Ribosomal_L7Ae RNase_P_pop3 SpoU_sub_bind
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Anantharaman V|
|Number in seed:||44|
|Number in full:||128|
|Average length of the domain:||81.60 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||16.42 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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