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0  structures 213  species 0  interactions 4297  sequences 59  architectures

Family: 7tm_3 (PF00003)

Summary: 7 transmembrane sweet-taste receptor of 3 GCPR

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This is the Wikipedia entry entitled "Class C GPCR". More...

Class C GPCR Edit Wikipedia article

7 transmembrane receptor (metabotropic glutamate family)
Identifiers
Symbol 7tm_3
Pfam PF00003
InterPro IPR000337
PROSITE PDOC00754

The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors.[1]

Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.

Subfamilies[edit]

Calcium-sensing receptor-related[edit]

GABAB receptors[edit]

Metabotropic glutamate receptors[edit]

RAIG[edit]

Taste receptors[edit]

Orphan[edit]

Other[edit]

References[edit]

  1. ^ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540. 

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

7 transmembrane sweet-taste receptor of 3 GCPR Provide feedback

This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G PF07562 which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor PF01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness [1].

Literature references

  1. Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF; , J Biol Chem. 2005;280:34296-34305.: Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. PUBMED:16076846 EPMC:16076846


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR017978

G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence [PUBMED:8170923]. The currently known clan members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs (http://www.gpcr.org/7tm/).

GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length [PUBMED:17266540]. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [PUBMED:1309649, PUBMED:8255296, PUBMED:10773016, PUBMED:9292726]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.

This entry represents the C-terminal region of family 3 GPCR receptor proteins, which contains the seven transmembrane region. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness [PUBMED:16076846].

Gene Ontology

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Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(109)
Full
(4297)
Representative proteomes NCBI
(3557)
Meta
(7)
RP15
(448)
RP35
(660)
RP55
(1746)
RP75
(2615)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(109)
Full
(4297)
Representative proteomes NCBI
(3557)
Meta
(7)
RP15
(448)
RP35
(660)
RP55
(1746)
RP75
(2615)
Alignment:
Format:
Order:
Sequence:
Gaps:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(109)
Full
(4297)
Representative proteomes NCBI
(3557)
Meta
(7)
RP15
(448)
RP35
(660)
RP55
(1746)
RP75
(2615)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

HMM logo

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Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Author: Sonnhammer ELL
Number in seed: 109
Number in full: 4297
Average length of the domain: 227.40 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 32.05 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.8 25.8
Trusted cut-off 25.8 26.3
Noise cut-off 25.7 25.7
Model length: 238
Family (HMM) version: 17
Download: download the raw HMM for this family

Species distribution

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