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160  structures 448  species 0  interactions 15994  sequences 108  architectures

Family: Crystall (PF00030)

Summary: Beta/Gamma crystallin

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Beta gamma crystallin". More...

Beta gamma crystallin Edit Wikipedia article

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Beta/Gamma crystallin Provide feedback

The alignment comprises two Greek key motifs since the similarity between them is very low.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001064

The crystallins are water-soluble structural proteins that occur in high concentration in the cytoplasm of eye lens fibre cells. Four major groups of crystallin have been distinguished on the basis of size, charge and immunological properties: alpha-, beta- and gamma-crystallins occur in all vertebrate classes (though gamma-crystallins are low or absent in avian lenses); and delta-crystallin is found exclusively in reptiles and birds [ PUBMED:2688200 , PUBMED:7634077 ].

This entry represents beta and gamma- crystallin which form a family of related proteins [ PUBMED:2107329 , PUBMED:3064189 ]. Structurally, beta and gamma crystallins are composed of two similar domains which, in turn, are each composed of two similar motifs with the two domains connected by a short connecting peptide. Each motif, which is about forty amino acid residues long, is folded in a distinctive 'Greek key' pattern.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan gCrystallin (CL0333), which has the following description:

This superfamily includes a number of mammalian crystallins as well as ancestral beta gamma-crystallin precursor structures.

The clan contains the following 8 members:

Crystall Crystall_2 Crystall_3 Crystall_4 IL4_i_Ig Inhibitor_I36 MiAMP1 Yeast-kill-tox

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(88)
Full
(15994)
Representative proteomes UniProt
(26550)
RP15
(1118)
RP35
(4881)
RP55
(13865)
RP75
(18417)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(88)
Full
(15994)
Representative proteomes UniProt
(26550)
RP15
(1118)
RP35
(4881)
RP55
(13865)
RP75
(18417)
Alignment:
Format:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(88)
Full
(15994)
Representative proteomes UniProt
(26550)
RP15
(1118)
RP35
(4881)
RP55
(13865)
RP75
(18417)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Swissprot_feature_table
Previous IDs: crystall;
Type: Domain
Sequence Ontology: SO:0000417
Author: Sonnhammer ELL
Number in seed: 88
Number in full: 15994
Average length of the domain: 80.90 aa
Average identity of full alignment: 31 %
Average coverage of the sequence by the domain: 46.53 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.3 21.3
Trusted cut-off 21.3 21.3
Noise cut-off 21.2 21.2
Model length: 82
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Crystall domain has been found. There are 160 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JG52 View 3D Structure Click here
A0A0G2JG52 View 3D Structure Click here
A0A0G2JG52 View 3D Structure Click here
A0A0G2JG52 View 3D Structure Click here
A0A0G2JG52 View 3D Structure Click here
A0A0G2JG52 View 3D Structure Click here
A0A0G2JVZ7 View 3D Structure Click here
A0A0G2JVZ7 View 3D Structure Click here
A0A0G2JVZ7 View 3D Structure Click here
A0A0G2JVZ7 View 3D Structure Click here
A0A0G2JVZ7 View 3D Structure Click here
A0A0G2JVZ7 View 3D Structure Click here
A0A0G2L6V9 View 3D Structure Click here
A0A0G2L6V9 View 3D Structure Click here
A0A0G2L6V9 View 3D Structure Click here
A0A0G2L6V9 View 3D Structure Click here
A0A0G2L6V9 View 3D Structure Click here
A0A0G2L6V9 View 3D Structure Click here
A0A0R4IGU1 View 3D Structure Click here
A0A0R4IGU1 View 3D Structure Click here
A0A0R4IM55 View 3D Structure Click here
A0A0R4IM55 View 3D Structure Click here
A0A286Y891 View 3D Structure Click here
A0A286Y891 View 3D Structure Click here
A0A286YB98 View 3D Structure Click here
A0A286YB98 View 3D Structure Click here
A0A2I3BQG2 View 3D Structure Click here
A0A2I3BQG2 View 3D Structure Click here
A0A2I3BQG2 View 3D Structure Click here
A0A2I3BQG2 View 3D Structure Click here
A0A2I3BQG2 View 3D Structure Click here
A0A2I3BQG2 View 3D Structure Click here
A0A2R8Q1I4 View 3D Structure Click here
A0A2R8Q1I4 View 3D Structure Click here
A0A2R8Q3L6 View 3D Structure Click here
A0A2R8Q3Y3 View 3D Structure Click here
A0A2R8Q3Y3 View 3D Structure Click here
A0A2R8Q5P1 View 3D Structure Click here
A0A2R8Q5P1 View 3D Structure Click here
A0A2R8Q815 View 3D Structure Click here
A0A2R8Q815 View 3D Structure Click here
A0A2R8QDL2 View 3D Structure Click here
A0A2R8QDL2 View 3D Structure Click here
A0A2R8QFJ6 View 3D Structure Click here
A0A2R8QFJ6 View 3D Structure Click here
A0A2R8QID2 View 3D Structure Click here
A0A2R8QID2 View 3D Structure Click here
A0A2R8QQZ8 View 3D Structure Click here
A0A2R8QQZ8 View 3D Structure Click here
A0A2R8QSE8 View 3D Structure Click here
A0A2R8QSE8 View 3D Structure Click here
A0A2R8RI32 View 3D Structure Click here
A0A2R8RI32 View 3D Structure Click here
A0A2R8RN74 View 3D Structure Click here
A0A2R8RN74 View 3D Structure Click here
A3KNR6 View 3D Structure Click here
A3KNR6 View 3D Structure Click here
A4FUJ9 View 3D Structure Click here
A4FUJ9 View 3D Structure Click here
A4FVH2 View 3D Structure Click here
A4FVH2 View 3D Structure Click here
A7E2K5 View 3D Structure Click here
A7E2K5 View 3D Structure Click here
A7E2K7 View 3D Structure Click here
A7E2K7 View 3D Structure Click here
A7MC89 View 3D Structure Click here
A7MC89 View 3D Structure Click here
A8E4S8 View 3D Structure Click here
A8E4S8 View 3D Structure Click here
A8KBB6 View 3D Structure Click here
A8KBB6 View 3D Structure Click here
B0S6M3 View 3D Structure Click here
B0S6M3 View 3D Structure Click here
B0S6N1 View 3D Structure Click here
B0S6N1 View 3D Structure Click here
B0S6N4 View 3D Structure Click here
B0S6N4 View 3D Structure Click here
B0S6P0 View 3D Structure Click here
B0S6P0 View 3D Structure Click here
B0UY86 View 3D Structure Click here
B0UY86 View 3D Structure Click here
B0UYN9 View 3D Structure Click here
B0UYN9 View 3D Structure Click here
B0UYP0 View 3D Structure Click here
B0UYP0 View 3D Structure Click here
B0V190 View 3D Structure Click here
B0V190 View 3D Structure Click here
B5M4A7 View 3D Structure Click here
B5M4A7 View 3D Structure Click here
D3ZD79 View 3D Structure Click here
D3ZD79 View 3D Structure Click here
D3ZD79 View 3D Structure Click here
D3ZD79 View 3D Structure Click here
D3ZD79 View 3D Structure Click here
D3ZD79 View 3D Structure Click here
D3ZEG1 View 3D Structure Click here
D3ZEG1 View 3D Structure Click here
E9QBU4 View 3D Structure Click here
E9QBU4 View 3D Structure Click here
E9QE97 View 3D Structure Click here
E9QE97 View 3D Structure Click here
F1M8T4 View 3D Structure Click here
F1M8T4 View 3D Structure Click here
F1M8T4 View 3D Structure Click here
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F1M8T4 View 3D Structure Click here
F1QGU7 View 3D Structure Click here
F1QGU7 View 3D Structure Click here
F1QYB6 View 3D Structure Click here
F1QYB6 View 3D Structure Click here
O35486 View 3D Structure Click here
O35486 View 3D Structure Click here
P02523 View 3D Structure Click here
P02523 View 3D Structure Click here
P02524 View 3D Structure Click here
P02524 View 3D Structure Click here
P02525 View 3D Structure Click here
P02525 View 3D Structure Click here
P02528 View 3D Structure Click here
P02528 View 3D Structure Click here
P02529 View 3D Structure Click here
P02529 View 3D Structure Click here
P04342 View 3D Structure Click here
P04342 View 3D Structure Click here
P04344 View 3D Structure Click here
P04344 View 3D Structure Click here
P04345 View 3D Structure Click here
P04345 View 3D Structure Click here
P05813 View 3D Structure Click here
P05813 View 3D Structure Click here
P07315 View 3D Structure Click here
P07315 View 3D Structure Click here
P07316 View 3D Structure Click here
P07316 View 3D Structure Click here
P07320 View 3D Structure Click here
P07320 View 3D Structure Click here
P0C5E9 View 3D Structure Click here
P0C5E9 View 3D Structure Click here
P10065 View 3D Structure Click here
P10065 View 3D Structure Click here
P10066 View 3D Structure Click here
P10066 View 3D Structure Click here
P10067 View 3D Structure Click here
P10067 View 3D Structure Click here
P10068 View 3D Structure Click here
P10068 View 3D Structure Click here
P11844 View 3D Structure Click here
P11844 View 3D Structure Click here
P14881 View 3D Structure Click here
P14881 View 3D Structure Click here
P22914 View 3D Structure Click here
P22914 View 3D Structure Click here
P26998 View 3D Structure Click here
P26998 View 3D Structure Click here
P43320 View 3D Structure Click here
P43320 View 3D Structure Click here
P53672 View 3D Structure Click here
P53672 View 3D Structure Click here
P53673 View 3D Structure Click here
P53673 View 3D Structure Click here
P53674 View 3D Structure Click here
P53674 View 3D Structure Click here
P56374 View 3D Structure Click here
P56374 View 3D Structure Click here
P62696 View 3D Structure Click here
P62696 View 3D Structure Click here
P62697 View 3D Structure Click here
P62697 View 3D Structure Click here
Q03740 View 3D Structure Click here
Q03740 View 3D Structure Click here
Q0D276 View 3D Structure Click here
Q0D276 View 3D Structure Click here
Q15I84 View 3D Structure Click here
Q15I84 View 3D Structure Click here
Q15I85 View 3D Structure Click here
Q15I85 View 3D Structure Click here
Q45FX9 View 3D Structure Click here
Q45FX9 View 3D Structure Click here
Q4VBU1 View 3D Structure Click here
Q4VBU1 View 3D Structure Click here
Q4VBU2 View 3D Structure Click here
Q4VBU2 View 3D Structure Click here
Q4ZHG3 View 3D Structure Click here
Q4ZHG3 View 3D Structure Click here
Q52JI3 View 3D Structure Click here
Q52JI3 View 3D Structure Click here
Q52JI4 View 3D Structure Click here
Q52JI4 View 3D Structure Click here
Q52JI6 View 3D Structure Click here
Q52JI6 View 3D Structure Click here
Q52JI7 View 3D Structure Click here
Q52JI7 View 3D Structure Click here
Q5XJ63 View 3D Structure Click here
Q5XJ63 View 3D Structure Click here
Q5XTN0 View 3D Structure Click here
Q5XTN0 View 3D Structure Click here
Q5XTN3 View 3D Structure Click here
Q5XTN3 View 3D Structure Click here
Q5XTN5 View 3D Structure Click here
Q5XTN5 View 3D Structure Click here
Q5XTN8 View 3D Structure Click here
Q5XTN8 View 3D Structure Click here
Q5XTP2 View 3D Structure Click here
Q5XTP2 View 3D Structure Click here
Q5XTP3 View 3D Structure Click here
Q5XTP3 View 3D Structure Click here
Q61597 View 3D Structure Click here
Q61597 View 3D Structure Click here
Q6DGY4 View 3D Structure Click here
Q6DGY4 View 3D Structure Click here
Q6DGY7 View 3D Structure Click here
Q6DGY7 View 3D Structure Click here
Q6DH12 View 3D Structure Click here
Q6DH12 View 3D Structure Click here
Q6IQU2 View 3D Structure Click here
Q6IQU2 View 3D Structure Click here
Q80W49 View 3D Structure Click here
Q80W49 View 3D Structure Click here
Q80W49 View 3D Structure Click here
Q80W49 View 3D Structure Click here
Q80W49 View 3D Structure Click here
Q80W49 View 3D Structure Click here
Q8CGQ0 View 3D Structure Click here
Q8CGQ0 View 3D Structure Click here
Q8N1P7 View 3D Structure Click here
Q8N1P7 View 3D Structure Click here
Q8N1P7 View 3D Structure Click here
Q8N1P7 View 3D Structure Click here
Q8N1P7 View 3D Structure Click here
Q8N1P7 View 3D Structure Click here
Q8VHL5 View 3D Structure Click here
Q8VHL5 View 3D Structure Click here
Q8WXF5 View 3D Structure Click here
Q8WXF5 View 3D Structure Click here
Q90WT1 View 3D Structure Click here
Q90WT1 View 3D Structure Click here
Q9CXV3 View 3D Structure Click here
Q9CXV3 View 3D Structure Click here
Q9JJU9 View 3D Structure Click here
Q9JJU9 View 3D Structure Click here
Q9JJV0 View 3D Structure Click here
Q9JJV0 View 3D Structure Click here
Q9JJV1 View 3D Structure Click here
Q9JJV1 View 3D Structure Click here
Q9WVJ5 View 3D Structure Click here
Q9WVJ5 View 3D Structure Click here
Q9Y4K1 View 3D Structure Click here
Q9Y4K1 View 3D Structure Click here
Q9Y4K1 View 3D Structure Click here
Q9Y4K1 View 3D Structure Click here
Q9Y4K1 View 3D Structure Click here
Q9Y4K1 View 3D Structure Click here