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743  structures 8151  species 0  interactions 375727  sequences 10039  architectures

Family: Response_reg (PF00072)

Summary: Response regulator receiver domain

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Response regulator receiver domain Provide feedback

This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

Literature references

  1. Pao GM, Saier MH; , J Mol Evol 1995;40:136-154.: Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. PUBMED:7699720 EPMC:7699720


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001789

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ PUBMED:16176121 ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ PUBMED:18076326 ]. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more [ PUBMED:12372152 ]. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) [ PUBMED:10966457 ]. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.

A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [ PUBMED:11934609 , PUBMED:11489844 ].

Bipartite response regulator proteins are involved in a two-component signal transduction system in bacteria, and certain eukaryotes like protozoa, that functions to detect and respond to environmental changes [ PUBMED:7699720 ]. These systems have been detected during host invasion, drug resistance, motility, phosphate uptake, osmoregulation, and nitrogen fixation, amongst others [ PUBMED:12015152 ]. The two-component system consists of a histidine protein kinase environmental sensor that phosphorylates the receiver domain of a response regulator protein; phosphorylation induces a conformational change in the response regulator, which activates the effector domain, triggering the cellular response [ PUBMED:10966457 ]. The domains of the two-component proteins are highly modular, but the core structures and activities are maintained.

The response regulators act as phosphorylation-activated switches to affect a cellular response, usually by transcriptional regulation. Most of these proteins consist of two domains, an N-terminal response regulator receiver domain, and a variable C-terminal effector domain with DNA-binding activity. This entry represents the response regulator receiver domain, which belongs to the CheY family, and receives the signal from the sensor partner in the two-component system.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan CheY (CL0304), which has the following description:

This clan includes the CheY-like response regulators from bacteria [1-2].

The clan contains the following 9 members:

FleQ OKR_DC_1_N RcsC RcsD_ABL Response_reg Response_reg_2 TadZ_N UPF0004 VpsR

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(52)
Full
(375727)
Representative proteomes UniProt
(1629105)
RP15
(44301)
RP35
(176914)
RP55
(380334)
RP75
(663928)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(52)
Full
(375727)
Representative proteomes UniProt
(1629105)
RP15
(44301)
RP35
(176914)
RP55
(380334)
RP75
(663928)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(52)
Full
(375727)
Representative proteomes UniProt
(1629105)
RP15
(44301)
RP35
(176914)
RP55
(380334)
RP75
(663928)
Raw Stockholm Download     Download   Download        
Gzipped Download     Download   Download        

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prodom
Previous IDs: response_reg;
Type: Domain
Sequence Ontology: SO:0000417
Author: Sonnhammer ELL , Griffiths-Jones SR , Finn RD , Fenech M
Number in seed: 52
Number in full: 375727
Average length of the domain: 112.30 aa
Average identity of full alignment: 25 %
Average coverage of the sequence by the domain: 29.25 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 30.2 30.2
Trusted cut-off 30.2 30.2
Noise cut-off 30.1 30.1
Model length: 112
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Response_reg domain has been found. There are 743 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0XZB5 View 3D Structure Click here
A0A0R0E422 View 3D Structure Click here
A0A0R0EI42 View 3D Structure Click here
A0A0R0ENQ9 View 3D Structure Click here
A0A0R0EUY3 View 3D Structure Click here
A0A0R0G3R5 View 3D Structure Click here
A0A0R0GJ59 View 3D Structure Click here
A0A0R0GRK7 View 3D Structure Click here
A0A0R0HRH5 View 3D Structure Click here
A0A0R0IRI5 View 3D Structure Click here
A0A0R0JGD4 View 3D Structure Click here
A0A0R0JLN5 View 3D Structure Click here
A0A0R0JU68 View 3D Structure Click here
A0A0R0K0Q6 View 3D Structure Click here
A0A0R0K0S8 View 3D Structure Click here
A0A0R0KCZ8 View 3D Structure Click here
A0A0R0KVT4 View 3D Structure Click here
A0A0R0LKY2 View 3D Structure Click here
A0A1D6E9X4 View 3D Structure Click here
A0A1D6EDG3 View 3D Structure Click here
A0A1D6EF02 View 3D Structure Click here
A0A1D6EF25 View 3D Structure Click here
A0A1D6ETT5 View 3D Structure Click here
A0A1D6F525 View 3D Structure Click here
A0A1D6FHD1 View 3D Structure Click here
A0A1D6G5R1 View 3D Structure Click here
A0A1D6G6S9 View 3D Structure Click here
A0A1D6GEQ7 View 3D Structure Click here
A0A1D6GJ22 View 3D Structure Click here
A0A1D6GRV4 View 3D Structure Click here
A0A1D6HD83 View 3D Structure Click here
A0A1D6HN97 View 3D Structure Click here
A0A1D6I9R1 View 3D Structure Click here
A0A1D6J4G3 View 3D Structure Click here
A0A1D6JU17 View 3D Structure Click here
A0A1D6KQE2 View 3D Structure Click here
A0A1D6KTY7 View 3D Structure Click here
A0A1D6L285 View 3D Structure Click here
A0A1D6L3N2 View 3D Structure Click here
A0A1D6LJ19 View 3D Structure Click here
A0A1D6LQI5 View 3D Structure Click here
A0A1D6LRB1 View 3D Structure Click here
A0A1D6N2S4 View 3D Structure Click here
A0A1D6N441 View 3D Structure Click here
A0A1D6P5H4 View 3D Structure Click here
A0A1D6Q542 View 3D Structure Click here
A0A1D6QJY6 View 3D Structure Click here
A0A368UG86 View 3D Structure Click here
A1A696 View 3D Structure Click here
A1A697 View 3D Structure Click here
A1A698 View 3D Structure Click here
A1A699 View 3D Structure Click here
A3BE68 View 3D Structure Click here
B4FKP5 View 3D Structure Click here
B6THK5 View 3D Structure Click here
B8A2Q1 View 3D Structure Click here
C0HE02 View 3D Structure Click here
C0HEV4 View 3D Structure Click here
C0P2S3 View 3D Structure Click here
C0PF17 View 3D Structure Click here
C6SX49 View 3D Structure Click here
C6T5J5 View 3D Structure Click here
C6TH15 View 3D Structure Click here
E3VJR1 View 3D Structure Click here
F1DK02 View 3D Structure Click here
F4JZT3 View 3D Structure Click here
F4K554 View 3D Structure Click here
I1JBW0 View 3D Structure Click here
I1JCF5 View 3D Structure Click here
I1JPB5 View 3D Structure Click here
I1JPB6 View 3D Structure Click here
I1JQR5 View 3D Structure Click here
I1JU86 View 3D Structure Click here
I1JWS5 View 3D Structure Click here
I1JX19 View 3D Structure Click here
I1JYH9 View 3D Structure Click here
I1JZ41 View 3D Structure Click here
I1JZW0 View 3D Structure Click here
I1K3M7 View 3D Structure Click here
I1K8P7 View 3D Structure Click here
I1KAC0 View 3D Structure Click here
I1KCL2 View 3D Structure Click here
I1KCV3 View 3D Structure Click here
I1KKW6 View 3D Structure Click here
I1KMU8 View 3D Structure Click here
I1KQE9 View 3D Structure Click here
I1KS30 View 3D Structure Click here
I1KXL8 View 3D Structure Click here
I1L0U9 View 3D Structure Click here
I1L2E2 View 3D Structure Click here
I1LBS2 View 3D Structure Click here
I1LCD5 View 3D Structure Click here
I1LI26 View 3D Structure Click here
I1LLD6 View 3D Structure Click here
I1LVH5 View 3D Structure Click here
I1LZL8 View 3D Structure Click here
I1M0T1 View 3D Structure Click here
I1MGI9 View 3D Structure Click here
I1MIR9 View 3D Structure Click here
I1MKC2 View 3D Structure Click here
I1MRN2 View 3D Structure Click here
I1MTM0 View 3D Structure Click here
I1MWY8 View 3D Structure Click here
I1MX26 View 3D Structure Click here
I1N045 View 3D Structure Click here
I1N8U4 View 3D Structure Click here
I1N9Y4 View 3D Structure Click here
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I1NCE1 View 3D Structure Click here
I1NCR4 View 3D Structure Click here
I1NIL8 View 3D Structure Click here
K7K1M2 View 3D Structure Click here
K7K4U9 View 3D Structure Click here
K7K757 View 3D Structure Click here
K7K767 View 3D Structure Click here
K7KBR1 View 3D Structure Click here
K7KGZ6 View 3D Structure Click here
K7KH59 View 3D Structure Click here
K7KIC3 View 3D Structure Click here
K7KMI1 View 3D Structure Click here
K7KQ93 View 3D Structure Click here
K7KRH0 View 3D Structure Click here
K7KUW6 View 3D Structure Click here
K7KZQ2 View 3D Structure Click here
K7L2C5 View 3D Structure Click here
K7L4Z5 View 3D Structure Click here
K7L4Z6 View 3D Structure Click here
K7LB30 View 3D Structure Click here
K7LGS0 View 3D Structure Click here
K7LHH0 View 3D Structure Click here
K7LMZ7 View 3D Structure Click here
K7LPT2 View 3D Structure Click here
K7LS21 View 3D Structure Click here
K7LTI9 View 3D Structure Click here
K7LZK3 View 3D Structure Click here
K7M476 View 3D Structure Click here
K7M630 View 3D Structure Click here
K7MGY5 View 3D Structure Click here
K7MIM3 View 3D Structure Click here
K7MKF2 View 3D Structure Click here
K7MKY0 View 3D Structure Click here
K7MPB5 View 3D Structure Click here
K7MWP7 View 3D Structure Click here
K7N076 View 3D Structure Click here
K7N4P0 View 3D Structure Click here
K7U4B4 View 3D Structure Click here
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K7UZU1 View 3D Structure Click here
K7VE33 View 3D Structure Click here
K7VFP6 View 3D Structure Click here
L7N689 View 3D Structure Click here
O07776 View 3D Structure Click here
O14002 View 3D Structure Click here
O14283 View 3D Structure Click here
O22267 View 3D Structure Click here
O23100 View 3D Structure Click here
O49397 View 3D Structure Click here
O69730 View 3D Structure Click here
O74539 View 3D Structure Click here
O80365 View 3D Structure Click here
O80366 View 3D Structure Click here
O82798 View 3D Structure Click here
P07330 View 3D Structure Click here
P08368 View 3D Structure Click here
P0A9Q1 View 3D Structure Click here
P0AA16 View 3D Structure Click here
P0ACZ4 View 3D Structure Click here
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P0AD01 View 3D Structure Click here
P0AE39 View 3D Structure Click here
P0AE67 View 3D Structure Click here
P0AE88 View 3D Structure Click here
P0AEC3 View 3D Structure Click here
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P0AEL8 View 3D Structure Click here
P0AEV1 View 3D Structure Click here
P0AF28 View 3D Structure Click here
P0AFB8 View 3D Structure Click here
P0AFJ5 View 3D Structure Click here
P0AFT5 View 3D Structure Click here
P0AFU4 View 3D Structure Click here
P0AGA6 View 3D Structure Click here
P0DMC5 View 3D Structure Click here
P0DMC7 View 3D Structure Click here
P14375 View 3D Structure Click here
P21866 View 3D Structure Click here
P23836 View 3D Structure Click here
P30843 View 3D Structure Click here
P30855 View 3D Structure Click here
P31802 View 3D Structure Click here
P38684 View 3D Structure Click here
P38889 View 3D Structure Click here
P39453 View 3D Structure Click here
P39928 View 3D Structure Click here
P49333 View 3D Structure Click here
P52076 View 3D Structure Click here
P52108 View 3D Structure Click here
P60611 View 3D Structure Click here
P62598 View 3D Structure Click here
P69228 View 3D Structure Click here
P71814 View 3D Structure Click here
P76340 View 3D Structure Click here
P87323 View 3D Structure Click here
P9WGL9 View 3D Structure Click here
P9WGM1 View 3D Structure Click here
P9WGM3 View 3D Structure Click here
P9WGM5 View 3D Structure Click here
P9WGM7 View 3D Structure Click here
P9WGM9 View 3D Structure Click here
P9WGN1 View 3D Structure Click here
P9WMF9 View 3D Structure Click here
Q06065 View 3D Structure Click here
Q07084 View 3D Structure Click here
Q0D3B6 View 3D Structure Click here
Q0DWC7 View 3D Structure Click here
Q0PVB3 View 3D Structure Click here
Q0WPQ2 View 3D Structure Click here
Q10N34 View 3D Structure Click here
Q1JSA0 View 3D Structure Click here
Q23917 View 3D Structure Click here
Q2FUY9 View 3D Structure Click here
Q2FVM7 View 3D Structure Click here
Q2FVQ9 View 3D Structure Click here
Q2FWH6 View 3D Structure Click here
Q2FWM4 View 3D Structure Click here
Q2FX09 View 3D Structure Click here
Q2FX97 View 3D Structure Click here
Q2FXN6 View 3D Structure Click here
Q2FY79 View 3D Structure Click here
Q2FYW0 View 3D Structure Click here
Q2G0E0 View 3D Structure Click here
Q2G1E1 View 3D Structure Click here
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Q2G2U6 View 3D Structure Click here
Q2HWG0 View 3D Structure Click here
Q2HWG1 View 3D Structure Click here
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Q2HWH1 View 3D Structure Click here
Q2QXY3 View 3D Structure Click here
Q2RAP3 View 3D Structure Click here
Q3S4A7 View 3D Structure Click here
Q54EN9 View 3D Structure Click here
Q54JZ2 View 3D Structure Click here
Q54RP6 View 3D Structure Click here
Q54SK5 View 3D Structure Click here
Q54SP4 View 3D Structure Click here
Q54SP4 View 3D Structure Click here
Q54U87 View 3D Structure Click here
Q54W36 View 3D Structure Click here
Q54YH4 View 3D Structure Click here
Q54YZ9 View 3D Structure Click here
Q551X9 View 3D Structure Click here
Q55CH1 View 3D Structure Click here
Q55E44 View 3D Structure Click here
Q55F68 View 3D Structure Click here
Q55FP2 View 3D Structure Click here
Q59M56 View 3D Structure Click here
Q5A4X5 View 3D Structure Click here
Q5A599 View 3D Structure Click here
Q5A872 View 3D Structure Click here
Q5AHA0 View 3D Structure Click here
Q5AKU6 View 3D Structure Click here
Q5N6V8 View 3D Structure Click here
Q5SML4 View 3D Structure Click here
Q5SML5 View 3D Structure Click here
Q67W50 View 3D Structure Click here
Q689G6 View 3D Structure Click here
Q689G9 View 3D Structure Click here
Q6AU68 View 3D Structure Click here
Q6H468 View 3D Structure Click here
Q6H805 View 3D Structure Click here
Q6K8X6 View 3D Structure Click here
Q6K9T0 View 3D Structure Click here
Q6LA42 View 3D Structure Click here
Q6LA43 View 3D Structure Click here
Q6YVX7 View 3D Structure Click here
Q75HW2 View 3D Structure Click here
Q75KW7 View 3D Structure Click here
Q7G8V2 View 3D Structure Click here
Q7XKS9 View 3D Structure Click here
Q7XN30 View 3D Structure Click here
Q7XQA6 View 3D Structure Click here
Q7XS69 View 3D Structure Click here
Q7XX84 View 3D Structure Click here
Q7Y0W5 View 3D Structure Click here
Q869S5 View 3D Structure Click here
Q86AT9 View 3D Structure Click here
Q86CZ2 View 3D Structure Click here
Q8GVV6 View 3D Structure Click here
Q8H7S7 View 3D Structure Click here
Q8L500 View 3D Structure Click here
Q8L9Y3 View 3D Structure Click here
Q93WK5 View 3D Structure Click here
Q940D0 View 3D Structure Click here
Q942A1 View 3D Structure Click here
Q95PI2 View 3D Structure Click here
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Q9FGT7 View 3D Structure Click here
Q9FJ16 View 3D Structure Click here
Q9FPR6 View 3D Structure Click here
Q9FXD6 View 3D Structure Click here
Q9FXQ7 View 3D Structure Click here
Q9KJN4 View 3D Structure Click here
Q9LKL2 View 3D Structure Click here
Q9LVG4 View 3D Structure Click here
Q9LYP5 View 3D Structure Click here
Q9LZJ8 View 3D Structure Click here
Q9M8Y4 View 3D Structure Click here
Q9M9B9 View 3D Structure Click here
Q9P7Q7 View 3D Structure Click here
Q9SB04 View 3D Structure Click here
Q9SHC2 View 3D Structure Click here
Q9SXL4 View 3D Structure Click here
Q9ZTP3 View 3D Structure Click here
Q9ZVD3 View 3D Structure Click here
Q9ZWJ9 View 3D Structure Click here
Q9ZWS6 View 3D Structure Click here
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