Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
73  structures 1398  species 0  interactions 28255  sequences 306  architectures

Family: bZIP_1 (PF00170)

Summary: bZIP transcription factor

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "BZIP domain". More...

BZIP domain Edit Wikipedia article

bZIP transcription factor
CREB.png
CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
Identifiers
SymbolbZIP_1
PfamPF00170
InterProIPR011616
PROSITEPDOC00036
SCOPe1ysa / SUPFAM
CDDcd14686
Membranome235

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.[1][2]

bZIP transcription factors

bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs.[3][4] An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants.[5] Interactions between bZIP transcription factors are numerous and complex [6][7][3] and play important roles in cancer development[8] in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues,[9] factors affecting reproductive functions,[10] and several other phenomena that affect human health.

bZIP domain containing proteins

  • AP-1 fos/jun heterodimer that forms a transcription factor
  • Jun-B transcription factor
  • CREB cAMP response element transcription factor
  • OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea Mays) kernels
  • NFE2L2 or Nrf2
  • Bzip Maf transcription factors

Human proteins containing this domain

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; MAFA; MAFB; NFE2; NFE2L2; NFE2L3; SNFT; XBP1

References

  1. ^ Ellenberger T (1994). "Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains". Curr. Opin. Struct. Biol. 4 (1): 12–21. doi:10.1016/S0959-440X(94)90054-X.
  2. ^ Hurst HC (1995). "Transcription factors 1: bZIP proteins". Protein Profile. 2 (2): 101–68. PMID 7780801.
  3. ^ a b Amoutzias, G. D.; Veron, A. S.; Weiner, J.; Robinson-Rechavi, M.; Bornberg-Bauer, E.; Oliver, S. G.; Robertson, D. L. (2007-03-01). "One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity". Molecular Biology and Evolution. 24 (3): 827–835. doi:10.1093/molbev/msl211. ISSN 0737-4038. PMID 17194801.
  4. ^ Amoutzias, Grigoris D.; Robertson, David L.; Van de Peer, Yves; Oliver, Stephen G. (2008-05-01). "Choose your partners: dimerization in eukaryotic transcription factors". Trends in Biochemical Sciences. 33 (5): 220–229. doi:10.1016/j.tibs.2008.02.002. ISSN 0968-0004. PMID 18406148.
  5. ^ Corrêa LG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M (2008). Shiu S (ed.). "The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes". PLoS ONE. 3 (8): e2944. doi:10.1371/journal.pone.0002944. PMC 2492810. PMID 18698409.
  6. ^ Vinson, Charles; Acharya, Asha; Taparowsky, Elizabeth J. (2006-01-01). "Deciphering B-ZIP transcription factor interactions in vitro and in vivo" (PDF). Biochimica et Biophysica Acta. 1759 (1–2): 4–12. doi:10.1016/j.bbaexp.2005.12.005. ISSN 0006-3002. PMID 16580748.
  7. ^ Newman, John R. S.; Keating, Amy E. (2003-06-27). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–2101. doi:10.1126/science.1084648. ISSN 1095-9203. PMID 12805554.
  8. ^ Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). "The role of ATF-2 in oncogenesis". BioEssays. 30 (4): 314–27. doi:10.1002/bies.20734. PMID 18348191.
  9. ^ Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). "Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family". Mol. Endocrinol. 16 (1): 184–99. doi:10.1210/me.16.1.184. PMID 11773448.
  10. ^ Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). "Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun". Endocrinology. 140 (5): 2268–79. doi:10.1210/en.140.5.2268. PMID 10218980.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

bZIP transcription factor Provide feedback

The Pfam entry includes the basic region and the leucine zipper region.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004827

The basic-leucine zipper (bZIP) domain transcription factors [ PUBMED:7780801 ] of eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region required for dimerisation.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan bZIP (CL0018), which has the following description:

This family of eukaryotic transcription factors contain a basic region adjacent to a leucine zipper.

The clan contains the following 3 members:

bZIP_1 bZIP_2 bZIP_Maf

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(15)
Full
(28255)
Representative proteomes UniProt
(47185)
RP15
(3452)
RP35
(12079)
RP55
(22523)
RP75
(31315)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(15)
Full
(28255)
Representative proteomes UniProt
(47185)
RP15
(3452)
RP35
(12079)
RP55
(22523)
RP75
(31315)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(15)
Full
(28255)
Representative proteomes UniProt
(47185)
RP15
(3452)
RP35
(12079)
RP55
(22523)
RP75
(31315)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: bZIP;
Type: Coiled-coil
Sequence Ontology: SO:0001080
Author: Sonnhammer ELL
Number in seed: 15
Number in full: 28255
Average length of the domain: 60.80 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 16.46 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.6 27.6
Trusted cut-off 27.6 27.6
Noise cut-off 27.5 27.5
Model length: 64
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the bZIP_1 domain has been found. There are 73 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A060D1N2 View 3D Structure Click here
A0A060D700 View 3D Structure Click here
A0A060D918 View 3D Structure Click here
A0A0G2K331 View 3D Structure Click here
A0A0N7KI44 View 3D Structure Click here
A0A0N7KMD3 View 3D Structure Click here
A0A0N7KSG4 View 3D Structure Click here
A0A0N7KUB6 View 3D Structure Click here
A0A0P0UYZ1 View 3D Structure Click here
A0A0P0V9J7 View 3D Structure Click here
A0A0P0VFR9 View 3D Structure Click here
A0A0P0VG62 View 3D Structure Click here
A0A0P0VWV8 View 3D Structure Click here
A0A0P0WFC8 View 3D Structure Click here
A0A0P0WNV7 View 3D Structure Click here
A0A0P0X1A0 View 3D Structure Click here
A0A0P0X3I8 View 3D Structure Click here
A0A0P0XR34 View 3D Structure Click here
A0A0R0EGQ1 View 3D Structure Click here
A0A0R0EMF9 View 3D Structure Click here
A0A0R0FII4 View 3D Structure Click here
A0A0R0G544 View 3D Structure Click here
A0A0R0GJQ0 View 3D Structure Click here
A0A0R0GWQ9 View 3D Structure Click here
A0A0R0HDY8 View 3D Structure Click here
A0A0R0HI77 View 3D Structure Click here
A0A0R0HQF0 View 3D Structure Click here
A0A0R0IG25 View 3D Structure Click here
A0A0R0IKI9 View 3D Structure Click here
A0A0R0IQB8 View 3D Structure Click here
A0A0R0IVB6 View 3D Structure Click here
A0A0R0KB07 View 3D Structure Click here
A0A0R0KCM8 View 3D Structure Click here
A0A0R0KHW1 View 3D Structure Click here
A0A0R0LBJ6 View 3D Structure Click here
A0A0R0LBM0 View 3D Structure Click here
A0A0R0LE00 View 3D Structure Click here
A0A0R4IAV4 View 3D Structure Click here
A0A0R4IB23 View 3D Structure Click here
A0A0R4IFU8 View 3D Structure Click here
A0A0R4IL04 View 3D Structure Click here
A0A1D6EHT9 View 3D Structure Click here
A0A1D6EI22 View 3D Structure Click here
A0A1D6EKJ8 View 3D Structure Click here
A0A1D6ELA3 View 3D Structure Click here
A0A1D6ES44 View 3D Structure Click here
A0A1D6ETY5 View 3D Structure Click here
A0A1D6F2B0 View 3D Structure Click here
A0A1D6FB04 View 3D Structure Click here
A0A1D6FSK0 View 3D Structure Click here
A0A1D6G7X6 View 3D Structure Click here
A0A1D6G817 View 3D Structure Click here
A0A1D6G9R8 View 3D Structure Click here
A0A1D6GBD7 View 3D Structure Click here
A0A1D6GVL6 View 3D Structure Click here
A0A1D6GZE6 View 3D Structure Click here
A0A1D6H348 View 3D Structure Click here
A0A1D6H3I5 View 3D Structure Click here
A0A1D6H494 View 3D Structure Click here
A0A1D6H5N5 View 3D Structure Click here
A0A1D6HJ36 View 3D Structure Click here
A0A1D6HL81 View 3D Structure Click here
A0A1D6HRS4 View 3D Structure Click here
A0A1D6HTP7 View 3D Structure Click here
A0A1D6HVZ1 View 3D Structure Click here
A0A1D6I5T6 View 3D Structure Click here
A0A1D6I6H2 View 3D Structure Click here
A0A1D6I6Z4 View 3D Structure Click here
A0A1D6I8V3 View 3D Structure Click here
A0A1D6I8V4 View 3D Structure Click here
A0A1D6ITC6 View 3D Structure Click here
A0A1D6IXE5 View 3D Structure Click here
A0A1D6IXU0 View 3D Structure Click here
A0A1D6IYI8 View 3D Structure Click here
A0A1D6J7Y3 View 3D Structure Click here
A0A1D6J892 View 3D Structure Click here
A0A1D6JFC7 View 3D Structure Click here
A0A1D6JMA9 View 3D Structure Click here
A0A1D6JVI7 View 3D Structure Click here
A0A1D6KD18 View 3D Structure Click here
A0A1D6KGU5 View 3D Structure Click here
A0A1D6KKX7 View 3D Structure Click here
A0A1D6KYS3 View 3D Structure Click here
A0A1D6L661 View 3D Structure Click here
A0A1D6L7Q3 View 3D Structure Click here
A0A1D6L7S7 View 3D Structure Click here
A0A1D6L7T5 View 3D Structure Click here
A0A1D6L8V1 View 3D Structure Click here
A0A1D6LVA4 View 3D Structure Click here
A0A1D6LWH9 View 3D Structure Click here
A0A1D6M550 View 3D Structure Click here
A0A1D6MEG6 View 3D Structure Click here
A0A1D6MK18 View 3D Structure Click here
A0A1D6MR32 View 3D Structure Click here
A0A1D6MZQ6 View 3D Structure Click here
A0A1D6N6P8 View 3D Structure Click here
A0A1D6N9B1 View 3D Structure Click here
A0A1D6NGU9 View 3D Structure Click here
A0A1D6NSD5 View 3D Structure Click here
A0A1D6NV24 View 3D Structure Click here
A0A1D6P4D7 View 3D Structure Click here
A0A1D6PBP5 View 3D Structure Click here
A0A1D6PF68 View 3D Structure Click here
A0A1D6Q2E2 View 3D Structure Click here
A0A1D6QHS9 View 3D Structure Click here
A0A1D6QJ26 View 3D Structure Click here
A0A1D6QK71 View 3D Structure Click here
A0A1Q0Z8R9 View 3D Structure Click here
A0A2R8Q4A5 View 3D Structure Click here
A0A2R8QTZ5 View 3D Structure Click here
A1E240 View 3D Structure Click here
A1L224 View 3D Structure Click here
A2BFU3 View 3D Structure Click here
A2CEM8 View 3D Structure Click here
A2RUX8 View 3D Structure Click here
A3AAZ0 View 3D Structure Click here
A4ZGU1 View 3D Structure Click here
A7MBV8 View 3D Structure Click here
A8E7N0 View 3D Structure Click here
B0V1Q6 View 3D Structure Click here
B2DBE7 View 3D Structure Click here
B3DIE0 View 3D Structure Click here
B3DIW4 View 3D Structure Click here
B4F7X2 View 3D Structure Click here
B4F809 View 3D Structure Click here
B4F937 View 3D Structure Click here
B4F9S0 View 3D Structure Click here
B4FB01 View 3D Structure Click here
B4FC51 View 3D Structure Click here
B4FCD1 View 3D Structure Click here
B4FDP1 View 3D Structure Click here
B4FJ42 View 3D Structure Click here
B4FJT6 View 3D Structure Click here
B4FK42 View 3D Structure Click here
B4FPU8 View 3D Structure Click here
B4FSC3 View 3D Structure Click here
B4FW26 View 3D Structure Click here
B4FWJ9 View 3D Structure Click here
B4FYB5 View 3D Structure Click here
B6SUA9 View 3D Structure Click here
B6TLC2 View 3D Structure Click here
B6TPC6 View 3D Structure Click here
B6UHB7 View 3D Structure Click here
B6UHD0 View 3D Structure Click here
B6UHQ6 View 3D Structure Click here
B6UI01 View 3D Structure Click here
B6UIG1 View 3D Structure Click here
B7EPB8 View 3D Structure Click here
B7EU89 View 3D Structure Click here
B7ZXV7 View 3D Structure Click here
B8A0F0 View 3D Structure Click here
B9DGI8 View 3D Structure Click here
C0HG10 View 3D Structure Click here
C0HGK3 View 3D Structure Click here
C0HGY0 View 3D Structure Click here
C0HIB3 View 3D Structure Click here
C0PCW0 View 3D Structure Click here
C0PDU9 View 3D Structure Click here
C0Z2L5 View 3D Structure Click here
C4J4L1 View 3D Structure Click here
C4J6L7 View 3D Structure Click here
C4JAP7 View 3D Structure Click here
C4JAX3 View 3D Structure Click here
C6T1X5 View 3D Structure Click here
C6THT3 View 3D Structure Click here
D0Z5N1 View 3D Structure Click here
D3ZBH0 View 3D Structure Click here
D3ZLB7 View 3D Structure Click here
D3ZT85 View 3D Structure Click here
D3ZU42 View 3D Structure Click here
D4A7E1 View 3D Structure Click here
E3VNM4 View 3D Structure Click here
E7F1F6 View 3D Structure Click here
E7F1F7 View 3D Structure Click here
E7F9I0 View 3D Structure Click here
E7FCG3 View 3D Structure Click here
E7FFR4 View 3D Structure Click here
E7FGU9 View 3D Structure Click here
E9QDH4 View 3D Structure Click here
F1DK38 View 3D Structure Click here
F1QA69 View 3D Structure Click here
F1QGR6 View 3D Structure Click here
F1QW76 View 3D Structure Click here
F1R7I8 View 3D Structure Click here
F4K0H9 View 3D Structure Click here
F6VAN0 View 3D Structure Click here
F7FD47 View 3D Structure Click here
G3V7X9 View 3D Structure Click here
G3V909 View 3D Structure Click here
G5ECG2 View 3D Structure Click here
I1J9G7 View 3D Structure Click here
I1JBG3 View 3D Structure Click here
I1JDF7 View 3D Structure Click here
I1JET7 View 3D Structure Click here
I1JHM0 View 3D Structure Click here
I1JK14 View 3D Structure Click here
I1JLV5 View 3D Structure Click here
I1JM33 View 3D Structure Click here
I1JN50 View 3D Structure Click here
I1JRM9 View 3D Structure Click here
I1JRX0 View 3D Structure Click here
I1JT50 View 3D Structure Click here
I1JYB6 View 3D Structure Click here
I1K1W3 View 3D Structure Click here
I1K7P6 View 3D Structure Click here
I1KA28 View 3D Structure Click here
I1KFN0 View 3D Structure Click here
I1KI00 View 3D Structure Click here
I1KM03 View 3D Structure Click here
I1KVX1 View 3D Structure Click here
I1KWX8 View 3D Structure Click here
I1KXV2 View 3D Structure Click here
I1L516 View 3D Structure Click here
I1L9C8 View 3D Structure Click here
I1LEY4 View 3D Structure Click here
I1LJN8 View 3D Structure Click here
I1LLX5 View 3D Structure Click here
I1LPW5 View 3D Structure Click here
I1LSA0 View 3D Structure Click here
I1LWX9 View 3D Structure Click here
I1M336 View 3D Structure Click here
I1M571 View 3D Structure Click here
I1M889 View 3D Structure Click here
I1M8V4 View 3D Structure Click here
I1MAN9 View 3D Structure Click here
I1MBK7 View 3D Structure Click here
I1MC59 View 3D Structure Click here
I1MDS2 View 3D Structure Click here
I1MIH5 View 3D Structure Click here
I1MKN5 View 3D Structure Click here
I1MMC8 View 3D Structure Click here
I1MMF5 View 3D Structure Click here
I1MVI7 View 3D Structure Click here
I1MY15 View 3D Structure Click here
I1MYW1 View 3D Structure Click here
I1N137 View 3D Structure Click here
I1N4U0 View 3D Structure Click here
I1N6I0 View 3D Structure Click here
I1N7B0 View 3D Structure Click here
I1N8K2 View 3D Structure Click here
I1NAM6 View 3D Structure Click here
I1NC96 View 3D Structure Click here
I1ND16 View 3D Structure Click here
I1NE19 View 3D Structure Click here
I1NIQ1 View 3D Structure Click here
K7K4G6 View 3D Structure Click here
K7K6N5 View 3D Structure Click here
K7K7E4 View 3D Structure Click here
K7K7Z2 View 3D Structure Click here
K7K961 View 3D Structure Click here
K7KEP5 View 3D Structure Click here
K7KF09 View 3D Structure Click here
K7KFZ7 View 3D Structure Click here
K7KJP7 View 3D Structure Click here
K7KNF6 View 3D Structure Click here
K7KPT9 View 3D Structure Click here
K7KR05 View 3D Structure Click here
K7KSL3 View 3D Structure Click here
K7KT00 View 3D Structure Click here
K7LI97 View 3D Structure Click here
K7LKW0 View 3D Structure Click here
K7LN23 View 3D Structure Click here
K7LP48 View 3D Structure Click here
K7LQ64 View 3D Structure Click here
K7LRT7 View 3D Structure Click here
K7LT54 View 3D Structure Click here
K7LVQ8 View 3D Structure Click here
K7LVQ9 View 3D Structure Click here
K7LWF5 View 3D Structure Click here
K7LX18 View 3D Structure Click here
K7LZZ2 View 3D Structure Click here
K7M309 View 3D Structure Click here
K7M831 View 3D Structure Click here
K7M987 View 3D Structure Click here
K7MHS5 View 3D Structure Click here
K7MMI2 View 3D Structure Click here
K7MQ32 View 3D Structure Click here
K7MY32 View 3D Structure Click here
K7MZ80 View 3D Structure Click here
K7N091 View 3D Structure Click here
K7N2V3 View 3D Structure Click here
K7TX82 View 3D Structure Click here
K7U0H2 View 3D Structure Click here
K7U3X9 View 3D Structure Click here
K7UA52 View 3D Structure Click here
K7UBS2 View 3D Structure Click here
K7VAC7 View 3D Structure Click here
K7VGB7 View 3D Structure Click here
K7VIY9 View 3D Structure Click here
K7VQH0 View 3D Structure Click here
K7WHC4 View 3D Structure Click here
O22208 View 3D Structure Click here
O22763 View 3D Structure Click here
O22873 View 3D Structure Click here
O24646 View 3D Structure Click here
O35284 View 3D Structure Click here
O35451 View 3D Structure Click here
O43889 View 3D Structure Click here
O44743 View 3D Structure Click here
O49067 View 3D Structure Click here
O65683 View 3D Structure Click here
O70191 View 3D Structure Click here
O81002 View 3D Structure Click here
P01100 View 3D Structure Click here
P01101 View 3D Structure Click here
P05412 View 3D Structure Click here
P05627 View 3D Structure Click here
P09450 View 3D Structure Click here
P10158 View 3D Structure Click here
P12841 View 3D Structure Click here
P12959 View 3D Structure Click here
P13346 View 3D Structure Click here
P15066 View 3D Structure Click here
P15336 View 3D Structure Click here
P15337 View 3D Structure Click here
P15407 View 3D Structure Click here
P15408 View 3D Structure Click here
P16220 View 3D Structure Click here
P16951 View 3D Structure Click here
P17275 View 3D Structure Click here
P17325 View 3D Structure Click here
P17535 View 3D Structure Click here
P17544 View 3D Structure Click here
P18289 View 3D Structure Click here
P18846 View 3D Structure Click here
P18847 View 3D Structure Click here
P18848 View 3D Structure Click here
P18850 View 3D Structure Click here
P19880 View 3D Structure Click here
P21525 View 3D Structure Click here
P24068 View 3D Structure Click here
P24813 View 3D Structure Click here
P24898 View 3D Structure Click here
P27699 View 3D Structure Click here
P29596 View 3D Structure Click here
P29747 View 3D Structure Click here
P38749 View 3D Structure Click here
P39970 View 3D Structure Click here
P40535 View 3D Structure Click here
P40917 View 3D Structure Click here
P42774 View 3D Structure Click here
P42775 View 3D Structure Click here
P42776 View 3D Structure Click here
P42777 View 3D Structure Click here
P43273 View 3D Structure Click here
P47930 View 3D Structure Click here
P48755 View 3D Structure Click here
P51145 View 3D Structure Click here
P52890 View 3D Structure Click here
P52909 View 3D Structure Click here
P53539 View 3D Structure Click here
P78962 View 3D Structure Click here
P81269 View 3D Structure Click here
P97875 View 3D Structure Click here
Q00969 View 3D Structure Click here
Q00M78 View 3D Structure Click here
Q01147 View 3D Structure Click here
Q01663 View 3D Structure Click here
Q02100 View 3D Structure Click here
Q02930 View 3D Structure Click here
Q03060 View 3D Structure Click here
Q03061 View 3D Structure Click here
Q03935 View 3D Structure Click here
Q04088 View 3D Structure Click here
Q06507 View 3D Structure Click here
Q08182 View 3D Structure Click here
Q08BZ3 View 3D Structure Click here
Q09771 View 3D Structure Click here
Q09926 View 3D Structure Click here
Q0D3H8 View 3D Structure Click here
Q0DMG8 View 3D Structure Click here
Q0E342 View 3D Structure Click here
Q0E476 View 3D Structure Click here
Q0GPF1 View 3D Structure Click here
Q0GPF7 View 3D Structure Click here
Q0GPF8 View 3D Structure Click here
Q0GPF9 View 3D Structure Click here
Q0GPG1 View 3D Structure Click here
Q0GPG2 View 3D Structure Click here
Q0GPH4 View 3D Structure Click here
Q0GPH5 View 3D Structure Click here
Q0GPH7 View 3D Structure Click here
Q0GPI1 View 3D Structure Click here
Q0GPI2 View 3D Structure Click here
Q0GPI4 View 3D Structure Click here
Q0J3Z8 View 3D Structure Click here
Q0JHF1 View 3D Structure Click here
Q0JNL3 View 3D Structure Click here
Q10PC3 View 3D Structure Click here
Q16520 View 3D Structure Click here
Q1LYG4 View 3D Structure Click here
Q22156 View 3D Structure Click here
Q2QLP2 View 3D Structure Click here
Q2QXC3 View 3D Structure Click here
Q2QXL0 View 3D Structure Click here
Q39140 View 3D Structure Click here
Q39162 View 3D Structure Click here
Q39163 View 3D Structure Click here
Q39237 View 3D Structure Click here
Q4G097 View 3D Structure Click here
Q4JFH9 View 3D Structure Click here
Q501B2 View 3D Structure Click here
Q53Q70 View 3D Structure Click here
Q54ER9 View 3D Structure Click here
Q54GG9 View 3D Structure Click here
Q54LU5 View 3D Structure Click here
Q54Q90 View 3D Structure Click here
Q54RZ9 View 3D Structure Click here
Q54WN7 View 3D Structure Click here
Q54WU0 View 3D Structure Click here
Q54Y73 View 3D Structure Click here
Q55E93 View 3D Structure Click here
Q56FQ1 View 3D Structure Click here
Q5AB69 View 3D Structure Click here
Q5AJU7 View 3D Structure Click here
Q5FVM5 View 3D Structure Click here
Q5JMK6 View 3D Structure Click here
Q5N7C7 View 3D Structure Click here
Q5QNI5 View 3D Structure Click here
Q5RGA9 View 3D Structure Click here
Q5RH85 View 3D Structure Click here
Q5UEM7 View 3D Structure Click here
Q5Z4G3 View 3D Structure Click here
Q5Z6N9 View 3D Structure Click here
Q60765 View 3D Structure Click here
Q61817 View 3D Structure Click here
Q654B3 View 3D Structure Click here
Q66HA2 View 3D Structure Click here
Q67TQ5 View 3D Structure Click here
Q688Q7 View 3D Structure Click here
Q68CJ9 View 3D Structure Click here
Q69IL4 View 3D Structure Click here
Q69JJ9 View 3D Structure Click here
Q69KN5 View 3D Structure Click here
Q69T21 View 3D Structure Click here
Q69TW5 View 3D Structure Click here
Q69XV0 View 3D Structure Click here
Q6AU90 View 3D Structure Click here
Q6AUN3 View 3D Structure Click here
Q6AVM5 View 3D Structure Click here
Q6DGM8 View 3D Structure Click here
Q6ESB3 View 3D Structure Click here
Q6ETX0 View 3D Structure Click here
Q6F2N0 View 3D Structure Click here
Q6H434 View 3D Structure Click here
Q6H500 View 3D Structure Click here
Q6IVC2 View 3D Structure Click here
Q6IVC3 View 3D Structure Click here
Q6K3R9 View 3D Structure Click here
Q6NW59 View 3D Structure Click here
Q6NZT5 View 3D Structure Click here
Q6P0S4 View 3D Structure Click here
Q6P788 View 3D Structure Click here
Q6QDP7 View 3D Structure Click here
Q6S4P4 View 3D Structure Click here
Q6Z2L2 View 3D Structure Click here
Q6Z312 View 3D Structure Click here
Q6ZBS8 View 3D Structure Click here
Q6ZCW4 View 3D Structure Click here
Q6ZDF3 View 3D Structure Click here
Q6ZJI7 View 3D Structure Click here
Q6ZLB0 View 3D Structure Click here
Q70SY1 View 3D Structure Click here
Q75HX9 View 3D Structure Click here
Q78E65 View 3D Structure Click here
Q7E0Y1 View 3D Structure Click here
Q7PCC6 View 3D Structure Click here
Q7T351 View 3D Structure Click here
Q7X993 View 3D Structure Click here
Q7X9A8 View 3D Structure Click here
Q7XIZ3 View 3D Structure Click here
Q7ZVX7 View 3D Structure Click here
Q803K8 View 3D Structure Click here
Q84JK2 View 3D Structure Click here
Q84LG2 View 3D Structure Click here
Q86AF3 View 3D Structure Click here
Q8BH52 View 3D Structure Click here
Q8H1F0 View 3D Structure Click here
Q8K1L0 View 3D Structure Click here
Q8L5W2 View 3D Structure Click here
Q8L5Y2 View 3D Structure Click here
Q8LIB3 View 3D Structure Click here
Q8LN44 View 3D Structure Click here
Q8N1L9 View 3D Structure Click here
Q8R0S1 View 3D Structure Click here
Q8R1H8 View 3D Structure Click here
Q8RU59 View 3D Structure Click here
Q8RYD6 View 3D Structure Click here
Q8RYP6 View 3D Structure Click here
Q8RZ35 View 3D Structure Click here
Q8S5V5 View 3D Structure Click here
Q8SX87 View 3D Structure Click here
Q8TEY5 View 3D Structure Click here
Q8VWG0 View 3D Structure Click here
Q8W191 View 3D Structure Click here
Q8WYK2 View 3D Structure Click here
Q91XE9 View 3D Structure Click here
Q91ZR3 View 3D Structure Click here
Q93XM6 View 3D Structure Click here
Q93ZE2 View 3D Structure Click here
Q96BA8 View 3D Structure Click here
Q99941 View 3D Structure Click here
Q9C5Q2 View 3D Structure Click here
Q9CA46 View 3D Structure Click here
Q9D275 View 3D Structure Click here
Q9D2A5 View 3D Structure Click here
Q9ES19 View 3D Structure Click here
Q9FMC2 View 3D Structure Click here
Q9FMM7 View 3D Structure Click here
Q9FNB9 View 3D Structure Click here
Q9FRG2 View 3D Structure Click here
Q9FUD3 View 3D Structure Click here
Q9LES3 View 3D Structure Click here
Q9LFU3 View 3D Structure Click here
Q9LMY8 View 3D Structure Click here
Q9LQ65 View 3D Structure Click here
Q9LW45 View 3D Structure Click here
Q9LXX4 View 3D Structure Click here
Q9LZP8 View 3D Structure Click here
Q9M1G6 View 3D Structure Click here
Q9M2K4 View 3D Structure Click here
Q9M7Q2 View 3D Structure Click here
Q9M7Q3 View 3D Structure Click here
Q9M7Q4 View 3D Structure Click here
Q9M7Q5 View 3D Structure Click here
Q9MA75 View 3D Structure Click here
Q9N5A8 View 3D Structure Click here
Q9NR55 View 3D Structure Click here
Q9NS37 View 3D Structure Click here
Q9SG86 View 3D Structure Click here
Q9SI15 View 3D Structure Click here
Q9SIG8 View 3D Structure Click here
Q9SJN0 View 3D Structure Click here
Q9SX27 View 3D Structure Click here
Q9T062 View 3D Structure Click here
Q9VID3 View 3D Structure Click here
Q9VWW0 View 3D Structure Click here
Q9XZS8 View 3D Structure Click here
Q9Y2D1 View 3D Structure Click here
Q9Z125 View 3D Structure Click here
X1WCW7 View 3D Structure Click here