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635  structures 4458  species 0  interactions 29855  sequences 266  architectures

Family: Glyco_hydro_1 (PF00232)

Summary: Glycosyl hydrolase family 1

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Glycoside hydrolase family 1". More...

Glycoside hydrolase family 1 Edit Wikipedia article

Glycosyl hydrolase family 1
Identifiers
SymbolGlyco_hydro_1
PfamPF00232
InterProIPR001360
PROSITEPDOC00495
SCOP21cbg / SCOPe / SUPFAM
OPM superfamily125
OPM protein1vff

Glycoside hydrolase, family 1 is a family of glycoside hydrolases.

O-Glycosyl hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families[1][2][3]. This classification is available on the CAZy(CArbohydrate-Active EnZymes) web site[4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'.

Glycoside hydrolase family 1 CAZY GH_1 comprises enzymes with a number of known activities; beta-glucosidase (EC 3.2.1.21); beta-galactosidase (EC 3.2.1.23); 6-phospho-beta-galactosidase (EC 3.2.1.85); 6-phospho-beta-glucosidase (EC 3.2.1.86); lactase-phlorizin hydrolase (EC 3.2.1.62), (EC 3.2.1.108); beta-mannosidase (EC 3.2.1.25); myrosinase (EC 3.2.1.147).

Subfamilies

Human proteins containing this domain

GBA3; KL; KLB; LCT; LCTL;

References

  1. ^ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. PMID 7624375.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–859. PMID 8535779.
  3. ^ Bairoch A (1999). "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT": -. {{cite journal}}: Cite journal requires |journal= (help)
  4. ^ Henrissat B, Coutinho PM (1999). "Carbohydrate-Active Enzymes server": -. {{cite journal}}: Cite journal requires |journal= (help)

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No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001360

O-Glycosyl hydrolases ( EC ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ PUBMED:7624375 , PUBMED:8535779 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 1 CAZY comprises enzymes with a number of known activities; beta-glucosidase ( EC ); beta-galactosidase ( EC ); 6-phospho-beta-galactosidase ( EC ); 6-phospho-beta-glucosidase ( EC ); lactase-phlorizin hydrolase ( EC ), ( EC ); beta-mannosidase ( EC ); myrosinase ( EC ).

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(11)
Full
(29855)
Representative proteomes UniProt
(89855)
RP15
(3294)
RP35
(12985)
RP55
(26931)
RP75
(41615)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(11)
Full
(29855)
Representative proteomes UniProt
(89855)
RP15
(3294)
RP35
(12985)
RP55
(26931)
RP75
(41615)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(11)
Full
(29855)
Representative proteomes UniProt
(89855)
RP15
(3294)
RP35
(12985)
RP55
(26931)
RP75
(41615)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: glycosyl_hydro1;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 11
Number in full: 29855
Average length of the domain: 351.1 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 89.2 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.6 22.6
Trusted cut-off 22.6 22.6
Noise cut-off 22.5 22.5
Model length: 453
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_hydro_1 domain has been found. There are 635 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A077Z3X0 View 3D Structure Click here
A0A077ZLM2 View 3D Structure Click here
A0A0D2GEA0 View 3D Structure Click here
A0A0D2GMC1 View 3D Structure Click here
A0A0G2JT97 View 3D Structure Click here
A0A0G2JVP8 View 3D Structure Click here
A0A0H3GSS3 View 3D Structure Click here
A0A0H3GTI4 View 3D Structure Click here
A0A0H3GTM8 View 3D Structure Click here
A0A0H3GUC2 View 3D Structure Click here
A0A0H3GUJ3 View 3D Structure Click here
A0A0H3GX43 View 3D Structure Click here
A0A0H3GXA3 View 3D Structure Click here
A0A0H3GY47 View 3D Structure Click here
A0A0K0DSS9 View 3D Structure Click here
A0A0K0DTH7 View 3D Structure Click here
A0A0K0EFA8 View 3D Structure Click here
A0A0K0EIP0 View 3D Structure Click here
A0A0P0WLF3 View 3D Structure Click here
A0A0R0F6T6 View 3D Structure Click here
A0A0R0FV74 View 3D Structure Click here
A0A0R0FVQ2 View 3D Structure Click here
A0A0R0FXQ4 View 3D Structure Click here
A0A0R0G789 View 3D Structure Click here
A0A0R0G7V6 View 3D Structure Click here
A0A0R0GFB2 View 3D Structure Click here
A0A0R0GVF8 View 3D Structure Click here
A0A0R0GW17 View 3D Structure Click here
A0A0R0GY42 View 3D Structure Click here
A0A0R0H2R3 View 3D Structure Click here
A0A0R0H3T1 View 3D Structure Click here
A0A0R0H4T6 View 3D Structure Click here
A0A0R0HAJ8 View 3D Structure Click here
A0A0R0HB92 View 3D Structure Click here
A0A0R0HGH0 View 3D Structure Click here
A0A0R0HGM1 View 3D Structure Click here
A0A0R0HQ37 View 3D Structure Click here
A0A0R0IIZ3 View 3D Structure Click here
A0A0R0IM88 View 3D Structure Click here
A0A0R0IME8 View 3D Structure Click here