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89  structures 7408  species 0  interactions 19944  sequences 152  architectures

Family: Chorismate_bind (PF00425)

Summary: chorismate binding enzyme

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chorismate binding enzyme Provide feedback

This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.

Literature references

  1. Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE; , Proc Natl Acad Sci U S A 2001;98:6021-6026.: The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. PUBMED:11371633 EPMC:11371633

  2. Dosselaere F, Vanderleyden J; , Crit Rev Microbiol 2001;27:75-131.: A metabolic node in action: chorismate-utilizing enzymes in microorganisms. PUBMED:11450855 EPMC:11450855


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR015890

This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase [ PUBMED:11371633 ]. Anthranilate synthase catalyses the reaction: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate. The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(99)
Full
(19944)
Representative proteomes UniProt
(94392)
RP15
(2313)
RP35
(9010)
RP55
(19625)
RP75
(34213)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(99)
Full
(19944)
Representative proteomes UniProt
(94392)
RP15
(2313)
RP35
(9010)
RP55
(19625)
RP75
(34213)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(99)
Full
(19944)
Representative proteomes UniProt
(94392)
RP15
(2313)
RP35
(9010)
RP55
(19625)
RP75
(34213)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_164 (release 1.0)
Previous IDs: chorismate_bind;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Kerrison ND
Number in seed: 99
Number in full: 19944
Average length of the domain: 250.40 aa
Average identity of full alignment: 34 %
Average coverage of the sequence by the domain: 49.89 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.8 21.8
Trusted cut-off 21.9 22.0
Noise cut-off 21.4 21.7
Model length: 256
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Chorismate_bind domain has been found. There are 89 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R0EQ27 View 3D Structure Click here
A0A0R0F675 View 3D Structure Click here
A0A0R0IAS6 View 3D Structure Click here
A0A0R0KN53 View 3D Structure Click here
A0A1D6GDZ9 View 3D Structure Click here
A0A1D6I2X7 View 3D Structure Click here
A0A1D6LA98 View 3D Structure Click here
A0A1D6LA98 View 3D Structure Click here
A0A1D6LNP0 View 3D Structure Click here
A0A1D8PMB0 View 3D Structure Click here
A0A1D8PS03 View 3D Structure Click here
A0A1I9LMN9 View 3D Structure Click here
B4F8P4 View 3D Structure Click here
I1J709 View 3D Structure Click here
I1NF54 View 3D Structure Click here
K7LKM5 View 3D Structure Click here
K7MPL4 View 3D Structure Click here
O05591 View 3D Structure Click here
O94277 View 3D Structure Click here
O94582 View 3D Structure Click here
P00895 View 3D Structure Click here
P00899 View 3D Structure Click here
P05041 View 3D Structure Click here
P0AEJ2 View 3D Structure Click here
P32068 View 3D Structure Click here
P32069 View 3D Structure Click here
P37254 View 3D Structure Click here
P38051 View 3D Structure Click here
P9WFW9 View 3D Structure Click here
P9WFX1 View 3D Structure Click here
P9WFX3 View 3D Structure Click here
Q2FYR9 View 3D Structure Click here
Q2FZL8 View 3D Structure Click here
Q2G098 View 3D Structure Click here
Q58475 View 3D Structure Click here
Q5Z856 View 3D Structure Click here
Q8I2T0 View 3D Structure Click here
Q8LPN3 View 3D Structure Click here
Q94GF1 View 3D Structure Click here
Q9M9V6 View 3D Structure Click here
Q9S7H8 View 3D Structure Click here
Q9XJ29 View 3D Structure Click here