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2496  structures 1485  species 0  interactions 46485  sequences 1083  architectures

Family: Bromodomain (PF00439)

Summary: Bromodomain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Bromodomain". More...

Bromodomain Edit Wikipedia article

Bromodomain
1e6i bromodomain.png
Ribbon diagram of the GCN5 bromodomain from Saccharomyces cerevisiae, colored from blue (N-terminus) to red (C-terminus).[1]
Identifiers
SymbolBromodomain
PfamPF00439
InterProIPR001487
SMARTSM00297
PROSITEPDOC00550
SCOPe1b91 / SUPFAM
CDDcd04369

A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones. Bromodomains, as the "readers" of lysine acetylation, are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes.[2] Their affinity is higher for regions where multiple acetylation sites exist in proximity. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices each separated by loop regions of variable lengths that form a hydrophobic pocket that recognizes the acetyl lysine.[1][3]

Discovery

The bromodomain was identified as a novel structural motif by John W. Tamkun and colleagues studying the drosophila gene Brahma/brm, and showed sequence similarity to genes involved in transcriptional activation.[4] The name "bromodomain" is derived from the relationship of this domain with Brahma and is unrelated to the chemical element bromine.

Bromodomain-containing proteins

Bromodomain-containing proteins can have a wide variety of functions, ranging from histone acetyltransferase activity and chromatin remodeling to transcriptional mediation and co-activation. Of the 43 known in 2015, 11 had two bromodomains, and one protein had 6 bromodomains.[2] Preparation, biochemical analysis, and structure determination of the bromodomain containing proteins have been described in details.[5]

Bromo- and Extra-Terminal domain (BET) family

A well-known example of a bromodomain family is the BET (Bromodomain and extraterminal domain) family. Members of this family include BRD2, BRD3, BRD4 and BRDT.

Other

However proteins such as ASH1L also contain a bromodomain. Dysfunction of BRD proteins has been linked to diseases such as human squamous cell carcinoma and other forms of cancer.[6] Histone acetyltransferases, including EP300 and PCAF, have bromodomains in addition to acetyl-transferase domains.[7][8] [9]

Not considered part of the BET family (yet containing a bromodomain) are BRD7, and BRD9.

Role in human disease

The role of bromodomains in translating a deregulated cell acetylome into disease phenotypes was recently unveiled by the development of small molecule bromodomain inhibitors. This breakthrough discovery highlighted bromodomain-containing proteins as key players in cancer biology, as well as inflammation and remyelination in multiple sclerosis.[2]

Members of the BET family have been implicated as targets in both human cancer[10][11] and multiple sclerosis.[12] BET inhibitors have shown therapeutic effects in multiple preclinical models of cancer and are currently in clinical trials in the United States.[13] Their application in multiple sclerosis is still in the preclinical stage.

Small molecule inhibitors of non-BET bromodomain proteins BRD7 and BRD9 have also been developed.[14][15]

See also

References

  1. ^ a b PDB: 1e6i​; Owen DJ, Ornaghi P, Yang JC, Lowe N, Evans PR, Ballario P, Neuhaus D, Filetici P, Travers AA (November 2000). "The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p". EMBO J. 19 (22): 6141–9. doi:10.1093/emboj/19.22.6141. PMC 305837. PMID 11080160.
  2. ^ a b c Ntranos, Achilles; Casaccia, Patrizia (2016). "Bromodomains: Translating the words of lysine acetylation into myelin injury and repair". Neuroscience Letters. 625: 4–10. doi:10.1016/j.neulet.2015.10.015. PMC 4841751. PMID 26472704.
  3. ^ Zeng L, Zhou MM (February 2002). "Bromodomain: an acetyl-lysine binding domain". FEBS Lett. 513 (1): 124–8. doi:10.1016/S0014-5793(01)03309-9. PMID 11911891.
  4. ^ Tamkun JW, Deuring R, Scott MP, Kissinger M, Pattatucci AM, Kaufman TC, Kennison JA (February 1992). "brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2". Cell. 68 (3): 561–72. doi:10.1016/0092-8674(92)90191-E. PMID 1346755.
  5. ^ Ren, C; Zeng, L; Zhou, MM (2016). "Preparation, Biochemical Analysis, and Structure Determination of the Bromodomain, an Acetyl-Lysine Binding Domain". Methods in Enzymology. 573: 321–43. doi:10.1016/bs.mie.2016.01.018. ISBN 9780128053652. PMID 27372760.
  6. ^ Filippakopoulos, Panagis (2012). "Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family". Cell. 149 (1): 214–231. doi:10.1016/j.cell.2012.02.013. PMC 3326523. PMID 22464331.
  7. ^ Dhalluin, C; Carlson, J. E.; Zeng, L; He, C; Aggarwal, A. K.; Zhou, M. M.; Zhou, Ming-Ming (1999). "Structure and ligand of a histone acetyltransferase bromodomain". Nature. 399 (6735): 491–6. doi:10.1038/20974. PMID 10365964.
  8. ^ Santillan, D. A.; Theisler, C. M.; Ryan, A. S.; Popovic, R; Stuart, T; Zhou, M. M.; Alkan, S; Zeleznik-Le, N. J. (2006). "Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype". Cancer Research. 66 (20): 10032–9. doi:10.1158/0008-5472.CAN-06-2597. PMID 17047066.
  9. ^ Hay, D. A.; Fedorov, O; Martin, S; Singleton, D. C.; Tallant, C; Wells, C; Picaud, S; Philpott, M; Monteiro, O. P.; Rogers, C. M.; Conway, S. J.; Rooney, T. P.; Tumber, A; Yapp, C; Filippakopoulos, P; Bunnage, M. E.; Müller, S; Knapp, S; Schofield, C. J.; Brennan, P. E. (2014). "Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains". Journal of the American Chemical Society. 136 (26): 9308–19. doi:10.1021/ja412434f. PMC 4183655. PMID 24946055.
  10. ^ Jung, Marie; Gelato, Kathy A; Fernández-Montalván, Amaury; Siegel, Stephan; Haendler, Bernard (2015-06-16). "Targeting BET bromodomains for cancer treatment". Epigenomics. 7 (3): 487–501. doi:10.2217/epi.14.91. PMID 26077433.
  11. ^ Da Costa, D.; Agathanggelou, A.; Perry, T.; Weston, V.; Petermann, E.; Zlatanou, A.; Oldreive, C.; Wei, W.; Stewart, G. (2013-07-19). "BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia". Blood Cancer Journal. 3 (7): e126. doi:10.1038/bcj.2013.24. PMC 3730202. PMID 23872705.
  12. ^ Gacias, Mar; Gerona-Navarro, Guillermo; Plotnikov, Alexander N.; Zhang, Guangtao; Zeng, Lei; Kaur, Jasbir; Moy, Gregory; Rusinova, Elena; Rodriguez, Yoel (2014). "Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression". Chemistry & Biology. 21 (7): 841–854. doi:10.1016/j.chembiol.2014.05.009. ISSN 1074-5521. PMC 4104156. PMID 24954007.
  13. ^ Shi, Junwei (2014). "The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition". Molecular Cell. 54 (5): 728–736. doi:10.1016/j.molcel.2014.05.016. PMC 4236231. PMID 24905006.
  14. ^ Clark, P. G.; Vieira, L. C.; Tallant, C; Fedorov, O; Singleton, D. C.; Rogers, C. M.; Monteiro, O. P.; Bennett, J. M.; Baronio, R; Müller, S; Daniels, D. L.; Méndez, J; Knapp, S; Brennan, P. E.; Dixon, D. J. (2015). "LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor". Angewandte Chemie International Edition. 54 (21): 6217–21. doi:10.1002/anie.201501394. PMC 4449114. PMID 25864491.
  15. ^ Theodoulou, N. H.; Bamborough, P; Bannister, A. J.; Becher, I; Bit, R. A.; Che, K. H.; Chung, C. W.; Dittmann, A; Drewes, G; Drewry, D. H.; Gordon, L; Grandi, P; Leveridge, M; Lindon, M; Michon, A. M.; Molnar, J; Robson, S. C.; Tomkinson, N. C.; Kouzarides, T; Prinjha, R. K.; Humphreys, P. G. (2015). "The Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition". Journal of Medicinal Chemistry. 59 (4): 1425–39. doi:10.1021/acs.jmedchem.5b00256. PMID 25856009.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Bromodomain Provide feedback

Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].

Literature references

  1. Haynes SR, Dollard C, Winston F, Beck S, Trowsdale J, Dawid IB; , Nucleic Acids Res 1992;20:2603-2603.: The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. PUBMED:1350857 EPMC:1350857

  2. Jeanmougin F, Wurtz J-M, Le Douarin B, Chambon P, Losson R; , Trends Biochem Sci 1997;22:151-153.: The bromodomain revisited. PUBMED:9175470 EPMC:9175470

  3. Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM; , Nature 1999;399:491-496.: Structure and ligand of a histone acetyltransferase bromodomain. PUBMED:10365964 EPMC:10365964


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001487

Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [ PUBMED:1350857 ]. Bromodomains can interact with acetylated lysine [ PUBMED:9175470 ]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [ PUBMED:7580139 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(43)
Full
(46485)
Representative proteomes UniProt
(84212)
RP15
(7402)
RP35
(18812)
RP55
(38538)
RP75
(52921)
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  Seed
(43)
Full
(46485)
Representative proteomes UniProt
(84212)
RP15
(7402)
RP35
(18812)
RP55
(38538)
RP75
(52921)
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(43)
Full
(46485)
Representative proteomes UniProt
(84212)
RP15
(7402)
RP35
(18812)
RP55
(38538)
RP75
(52921)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: bromodomain;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 43
Number in full: 46485
Average length of the domain: 84.20 aa
Average identity of full alignment: 27 %
Average coverage of the sequence by the domain: 9.86 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.7 21.7
Trusted cut-off 21.7 21.7
Noise cut-off 21.6 21.6
Model length: 84
Family (HMM) version: 27
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Bromodomain domain has been found. There are 2496 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JTM7 View 3D Structure Click here
A0A0G2JZU7 View 3D Structure Click here
A0A0G2K175 View 3D Structure Click here
A0A0K3AWB8 View 3D Structure Click here
A0A0K3AWB8 View 3D Structure Click here
A0A0N7KJQ5 View 3D Structure Click here
A0A0P0VXC7 View 3D Structure Click here
A0A0P0X662 View 3D Structure Click here
A0A0R0EVS6 View 3D Structure Click here
A0A0R0F105 View 3D Structure Click here
A0A0R0F5T5 View 3D Structure Click here
A0A0R0F849 View 3D Structure Click here
A0A0R0FAE3 View 3D Structure Click here
A0A0R0FEY3 View 3D Structure Click here
A0A0R0FU46 View 3D Structure Click here
A0A0R0GAG4 View 3D Structure Click here
A0A0R0GF96 View 3D Structure Click here
A0A0R0HW01 View 3D Structure Click here
A0A0R0I9Z0 View 3D Structure Click here
A0A0R0JUQ7 View 3D Structure Click here
A0A0R4IBT4 View 3D Structure Click here
A0A0R4IJ25 View 3D Structure Click here
A0A0R4IPF2 View 3D Structure Click here
A0A0R4IS80 View 3D Structure Click here
A0A0R4IUG1 View 3D Structure Click here
A0A0R4IVN8 View 3D Structure Click here
A0A0R4IXF6 View 3D Structure Click here
A0A0R4IY90 View 3D Structure Click here
A0A178W3E8 View 3D Structure Click here
A0A1D6EHJ1 View 3D Structure Click here
A0A1D6EUH1 View 3D Structure Click here
A0A1D6EWT6 View 3D Structure Click here
A0A1D6EYC4 View 3D Structure Click here
A0A1D6F4G5 View 3D Structure Click here
A0A1D6FEL1 View 3D Structure Click here
A0A1D6FFQ3 View 3D Structure Click here
A0A1D6GQK6 View 3D Structure Click here
A0A1D6H5K1 View 3D Structure Click here
A0A1D6HCG5 View 3D Structure Click here
A0A1D6I782 View 3D Structure Click here
A0A1D6IAY5 View 3D Structure Click here
A0A1D6ICQ0 View 3D Structure Click here
A0A1D6IGN7 View 3D Structure Click here
A0A1D6JEQ3 View 3D Structure Click here
A0A1D6JMQ5 View 3D Structure Click here
A0A1D6K1V2 View 3D Structure Click here
A0A1D6KI31 View 3D Structure Click here
A0A1D6KIX2 View 3D Structure Click here
A0A1D6LET0 View 3D Structure Click here
A0A1D6LKQ1 View 3D Structure Click here
A0A1D6MFX8 View 3D Structure Click here
A0A1D6P3J9 View 3D Structure Click here
A0A1D6PWP4 View 3D Structure Click here
A0A1D6PXD8 View 3D Structure Click here
A0A1D6QPE6 View 3D Structure Click here
A0A1D8PCV8 View 3D Structure Click here
A0A1D8PCV8 View 3D Structure Click here
A0A1D8PG88 View 3D Structure Click here
A0A1D8PG88 View 3D Structure Click here
A0A1D8PGK4 View 3D Structure Click here
A0A1D8PJG4 View 3D Structure Click here
A0A1D8PU33 View 3D Structure Click here
A0A1I9LTJ3 View 3D Structure Click here
A0A2R8Q080 View 3D Structure Click here
A0A2R8Q080 View 3D Structure Click here
A0A2R8Q521 View 3D Structure Click here
A0A2R8QER3 View 3D Structure Click here
A0A2R8QIG9 View 3D Structure Click here
A0A2R8QIG9 View 3D Structure Click here
A0A2R8QIG9 View 3D Structure Click here
A0A2R8QIG9 View 3D Structure Click here
A0A2R8QIG9 View 3D Structure Click here
A0A2R8QIG9 View 3D Structure Click here
A0A2R8QIN7 View 3D Structure Click here
A0A2R8RQ90 View 3D Structure Click here
A0A2R8RQ90 View 3D Structure Click here
A0A2R8RSE1 View 3D Structure Click here
A0A2R8RSE1 View 3D Structure Click here
A0A2R8RSS8 View 3D Structure Click here
A0A2R8RSS8 View 3D Structure Click here
A0A368UH32 View 3D Structure Click here
A2A484 View 3D Structure Click here
A2AHJ4 View 3D Structure Click here
A2AHJ4 View 3D Structure Click here
A2AUY4 View 3D Structure Click here
A2BIL7 View 3D Structure Click here
A3A538 View 3D Structure Click here
A4FVS4 View 3D Structure Click here
A4HU48 View 3D Structure Click here
A4HU48 View 3D Structure Click here
A4ICC9 View 3D Structure Click here
A4ID61 View 3D Structure Click here
A4ID86 View 3D Structure Click here
A5PN48 View 3D Structure Click here
A5PN48 View 3D Structure Click here
A8C4G9 View 3D Structure Click here
A8CYR1 View 3D Structure Click here
A8CYR1 View 3D Structure Click here
B0S7E1 View 3D Structure Click here
B2KF05 View 3D Structure Click here
B2RRD7 View 3D Structure Click here
B2RWS6 View 3D Structure Click here
B4FX33 View 3D Structure Click here
B4G1V8 View 3D Structure Click here
B5DF71 View 3D Structure Click here
B5DF71 View 3D Structure Click here
B7ZZM1 View 3D Structure Click here
D3Z8C5 View 3D Structure Click here
D3Z8C5 View 3D Structure Click here
D3ZGX8 View 3D Structure Click here
D3ZGX8 View 3D Structure Click here
D3ZJD2 View 3D Structure Click here
D3ZMD3 View 3D Structure Click here
D3ZT52 View 3D Structure Click here
D3ZT52 View 3D Structure Click here
D3ZT52 View 3D Structure Click here
D3ZT52 View 3D Structure Click here
D3ZT52 View 3D Structure Click here
D3ZT52 View 3D Structure Click here
D3ZUK4 View 3D Structure Click here
D3ZUW8 View 3D Structure Click here
D4A411 View 3D Structure Click here
D4A7T3 View 3D Structure Click here
D4A7T3 View 3D Structure Click here
D4AAI9 View 3D Structure Click here
D4AAI9 View 3D Structure Click here
D4ACF5 View 3D Structure Click here
D4ACX5 View 3D Structure Click here
E7EXJ5 View 3D Structure Click here
E7F805 View 3D Structure Click here
E7F8D8 View 3D Structure Click here
E7F8D8 View 3D Structure Click here
E7F8D8 View 3D Structure Click here
E7F8D8 View 3D Structure Click here
E7F8D8 View 3D Structure Click here
E7F8D8 View 3D Structure Click here
E7FE14 View 3D Structure Click here
E9PTG1 View 3D Structure Click here
E9PTN1 View 3D Structure Click here
E9Q166 View 3D Structure Click here
E9Q2Z1 View 3D Structure Click here
E9QG94 View 3D Structure Click here
E9QJ97 View 3D Structure Click here
E9QJ97 View 3D Structure Click here
F1LYI0 View 3D Structure Click here
F1M3B3 View 3D Structure Click here
F1M3B3 View 3D Structure Click here
F1M4U9 View 3D Structure Click here
F1M6Z0 View 3D Structure Click here
F1M858 View 3D Structure Click here
F1QEQ5 View 3D Structure Click here
F1QEQ5 View 3D Structure Click here
F1QFR1 View 3D Structure Click here
F1QQP6 View 3D Structure Click here
F1QQP6 View 3D Structure Click here
F1QVI1 View 3D Structure Click here
F1QW93 View 3D Structure Click here
F1QW93 View 3D Structure Click here
F1QYK7 View 3D Structure Click here
F1R0J6 View 3D Structure Click here
F1R0R1 View 3D Structure Click here
F1R4W7 View 3D Structure Click here
F1R5H6 View 3D Structure Click here
F1R5H6 View 3D Structure Click here
F1R6N2 View 3D Structure Click here
F1RCN2 View 3D Structure Click here
F4I9P7 View 3D Structure Click here
F4IAE9 View 3D Structure Click here
F4K639 View 3D Structure Click here
F6P390 View 3D Structure Click here
F7FKH2 View 3D Structure Click here
F8W3C9 View 3D Structure Click here
F8W3C9 View 3D Structure Click here
G3V661 View 3D Structure Click here
G3X9B4 View 3D Structure Click here
G5E8P1 View 3D Structure Click here
G5EEY5 View 3D Structure Click here
G5EEY5 View 3D Structure Click here
G5EEY5 View 3D Structure Click here
G5EEY5 View 3D Structure Click here
G5EEY5 View 3D Structure Click here
G5EF53 View 3D Structure Click here
G5EGM3 View 3D Structure Click here
G5EGM3 View 3D Structure Click here
I1JNY5 View 3D Structure Click here
I1K7C3 View 3D Structure Click here
I1KLF3 View 3D Structure Click here
I1KTI1 View 3D Structure Click here
I1L578 View 3D Structure Click here
I1LUL1 View 3D Structure Click here
I1LWH4 View 3D Structure Click here
I1M022 View 3D Structure Click here
I1M0F7 View 3D Structure Click here
I1M1L5 View 3D Structure Click here
I1M2A6 View 3D Structure Click here
I1M2K1 View 3D Structure Click here
I1ME28 View 3D Structure Click here
I1ME31 View 3D Structure Click here
I1MEC5 View 3D Structure Click here
I1MEZ0 View 3D Structure Click here
I1MLM9 View 3D Structure Click here
I1N0N0 View 3D Structure Click here
I1N5T6 View 3D Structure Click here
I1N9L6 View 3D Structure Click here
K7KHM0 View 3D Structure Click here
K7KJP5 View 3D Structure Click here
K7KL46 View 3D Structure Click here
K7KMV6 View 3D Structure Click here
K7KVK4 View 3D Structure Click here
K7L905 View 3D Structure Click here
K7LA55 View 3D Structure Click here
K7LA57 View 3D Structure Click here
K7LAM8 View 3D Structure Click here
K7LBN8 View 3D Structure Click here
K7LPG7 View 3D Structure Click here
K7LT69 View 3D Structure Click here
K7LUD5 View 3D Structure Click here
K7LVC8 View 3D Structure Click here
K7M2K1 View 3D Structure Click here
K7MBB4 View 3D Structure Click here
K7MEC9 View 3D Structure Click here
K7MFH1 View 3D Structure Click here
K7MQ05 View 3D Structure Click here
K7MSY3 View 3D Structure Click here
K7MSY4 View 3D Structure Click here
K7MSY5 View 3D Structure Click here
K7TPV5 View 3D Structure Click here
K7UCQ4 View 3D Structure Click here
K7UJZ6 View 3D Structure Click here
K7UZG6 View 3D Structure Click here
O01905 View 3D Structure Click here
O15016 View 3D Structure Click here
O15164 View 3D Structure Click here
O48523 View 3D Structure Click here
O60885 View 3D Structure Click here
O60885 View 3D Structure Click here
O64877 View 3D Structure Click here
O74350 View 3D Structure Click here
O74964 View 3D Structure Click here
O76561 View 3D Structure Click here
O88379 View 3D Structure Click here
O88665 View 3D Structure Click here
O94421 View 3D Structure Click here
O95696 View 3D Structure Click here
P13709 View 3D Structure Click here
P13709 View 3D Structure Click here
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