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131  structures 1359  species 0  interactions 36162  sequences 1032  architectures

Family: SAM_1 (PF00536)

Summary: SAM domain (Sterile alpha motif)

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Sterile alpha motif". More...

Sterile alpha motif Edit Wikipedia article

SAM domain (Sterile alpha motif)
Identifiers
SymbolSAM_1
PfamPF00536
InterProIPR001660
SMARTSAM
SCOPe1b0x / SUPFAM
CDDcd09487
Ste50p-SAM
PDB 1uqv EBI.jpg
SAM domain from fungal protein Ste50p
Identifiers
SymbolSte50p-SAM
PfamPF09235
Pfam clanCL0003
InterProIPR015316
SCOPe1uqv / SUPFAM

In molecular biology, the protein domain Sterile alpha motif (or SAM) is a putative protein interaction module present in a wide variety of proteins[1] involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms.[2] SAM domains have been shown to homo- and hetero-oligomerise, forming multiple self-association architectures and also binding to various non-SAM domain-containing proteins,[3] nevertheless with a low affinity constant.[4]

SAM domains also appear to possess the ability to bind RNA.[5] Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA, binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. The 3D crystal structure of the Smaug RNA-binding region shows a cluster of positively charged residues on the Smaug-SAM domain, which could be the RNA-binding surface. This electropositive potential is unique among all previously determined SAM-domain structures and is conserved among Smaug-SAM homologs. These results suggest that the SAM domain might have a primary role in RNA binding.

Structural analyses show that the SAM domain is arranged in a small five-helix bundle with two large interfaces.[3] In the case of the SAM domain of EPHB2, each of these interfaces is able to form dimers. The presence of these two distinct intermonomers binding surface suggest that SAM could form extended polymeric structures.[4]

Fungal SAM

In molecular biology, the protein domain Ste50p mainly in fungi and some other types of eukaryotes. It plays a role in the mitogen-activated protein kinase cascades, a type of cell signalling that helps the cell respond to external stimuli, more specifically mating, cell growth, and osmo-tolerance [6] in fungi.

Function

The protein domain Ste50p has a role in detecting pheromones for mating. It is thought to be found bound to Ste11p in order to prolong the pheromone-induced signaling response. Furthermore, it is also involved in aiding the cell to respond to nitrogen starvation.[7]

Structure

The fungal Ste50p SAM consists of six helices, which form a compact, globular fold. It is a monomer in solution and often undergoes heterodimerisation (and in some cases oligomerisation) of the protein.[7]

Protein interaction

The SAM domain of Ste50p often interacts with the SAM domain of Ste11p. They form bonds through this association. It is important to note that the SAM domain of one protein will bind to the SAM of a different protein. SAM domains do not self-associate in vitro.[7] There is significant evidence for Ste50p oligomerization in vivo.[8]

Human proteins containing this domain

ANKS1A; ANKS1B; ANKS3; ANKS4B; ANKS6; BFAR; BICC1; CASKIN1; CASKIN2; CENTD1; CNKSR2; CNKSR3; DDHD2; EPHA1; EPHA10; EPHA2; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; FAM59A; HPH2; INPPL1; L3MBTL3; PHC1; PHC2; PHC3; PPFIA1; PPFIA2; PPFIA3; PPFIA4; PPFIBP1; PPFIBP2; SAMD1; SAMD13; SAMD14; SAMD3; SAMD4A; SAMD4B; SAMD5; SAMD7; SAMD8; SAMD9; SCMH1; SCML1; SCML2; SEC23IP; SGMS1; SHANK1; SHANK2; SHANK3; STARD13; UBP1; USH1G; ZCCHC14; p63; p73;

References

  1. ^ Bork P, Ponting CP, Hofmann K, Schultz J (1997). "SAM as a protein interaction domain involved in developmental regulation". Protein Sci. 6 (1): 249–253. doi:10.1002/pro.5560060128. PMC 2143507. PMID 9007998.
  2. ^ Pawson T, Stapleton D, Balan I, Sicheri F (1999). "The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization". Nat. Struct. Biol. 6 (1): 44–49. doi:10.1038/4917. PMID 9886291.
  3. ^ a b Simon J, Peterson AJ, Kyba M, Bornemann D, Morgan K, Brock HW (1997). "A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions". Mol. Cell. Biol. 17 (11): 6683–6692. doi:10.1128/MCB.17.11.6683. PMC 232522. PMID 9343432.
  4. ^ a b Goodwill KE, Thanos CD, Bowie JU (1999). "Oligomeric structure of the human EphB2 receptor SAM domain" (PDF). Science. 283 (5403): 833–836. doi:10.1126/science.283.5403.833. PMID 9933164.
  5. ^ Bowie JU, Kim CA (2003). "SAM domains: uniform structure, diversity of function". Trends Biochem. Sci. 28 (12): 625–628. doi:10.1016/j.tibs.2003.11.001. PMID 14659692.
  6. ^ Posas, F.; Witten, E. A.; Saito, H. (1998). "Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway". Molecular and Cellular Biology. 18 (10): 5788–5796. doi:10.1128/mcb.18.10.5788. PMC 109165. PMID 9742096.
  7. ^ a b c Grimshaw SJ, Mott HR, Stott KM, Nielsen PR, Evetts KA, Hopkins LJ, Nietlispach D, Owen D (January 2004). "Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM". J. Biol. Chem. 279 (3): 2192–201. doi:10.1074/jbc.M305605200. PMID 14573615.
  8. ^ Slaughter, BD; Huff JM; Wiegraebe W; Schwartz JW; Li R (2008). "SAM domain-based protein oligomerization observed by live-cell fluorescence fluctuation spectroscopy". PLOS ONE. 3 (4): e1931. doi:10.1371/journal.pone.0001931. PMC 2291563. PMID 18431466. open access
This article incorporates text from the public domain Pfam and InterPro: IPR001660

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

SAM domain (Sterile alpha motif) Provide feedback

It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.

Literature references

  1. Ponting CP; , Protein Sci 1995;4:1928-1930.: SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins. PUBMED:8528090 EPMC:8528090

  2. Schultz J, Ponting CP, Hofmann K, Bork P; , Protein Sci 1997;6:249-253.: SAM as a protein interaction domain involved in developmental regulation. PUBMED:9007998 EPMC:9007998

  3. Stapleton D, Balan I, Pawson T, Sicheri F; , Nat Struct Biol 1999;6:44-49.: The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. PUBMED:9886291 EPMC:9886291


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001660

The sterile alpha motif (SAM) domain is a putative protein interaction module present in a wide variety of proteins [ PUBMED:9007998 ] involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms [ PUBMED:9886291 ]. SAM domains have been shown to homo- and hetero-oligomerise, forming multiple self-association architectures and also binding to various non-SAM domain-containing proteins [ PUBMED:9343432 ], nevertheless with a low affinity constant [ PUBMED:9933164 ]. SAM domains also appear to possess the ability to bind RNA [ PUBMED:14659692 ]. Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA, binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. The 3D crystal structure of the Smaug RNA-binding region shows a cluster of positively charged residues on the Smaug-SAM domain, which could be the RNA-binding surface. This electropositive potential is unique among all previously determined SAM-domain structures and is conserved among Smaug-SAM homologues. These results suggest that the SAM domain might have a primary role in RNA binding.

Structural analyses show that the SAM domain is arranged in a small five-helix bundle with two large interfaces [ PUBMED:9343432 ]. In the case of the SAM domain of EphB2, each of these interfaces is able to form dimers. The presence of these two distinct intermonomers binding surface suggest that SAM could form extended polymeric structures [ PUBMED:9933164 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan SAM (CL0003), which has the following description:

SAM domains are found in a diverse set of proteins, which include scaffolding proteins, transcription regulators, translational regulators tyrosine kinases and serine/threonine kinases [1-3]. SAM domains are found in all eukaryotes and some bacteria [3] . Structures of SAM domains reveal a common five helical structure. The SAM domain is involved in a variety of functions. The most widespread function is in domain-domain interactions. The SAM domain performs domain-domain interactions using multifarious arrangements of the SAM domain. More recently, the SAM domain within the Smaug protein has been demonstrated to bind to the Nanos 3' UTR translation control element (Rfam:RF00161) [3]. This clan currently only represents the diverse SAM domain family and does not contain the more divergent SAM/Pointed family (Pfam:PF02198).

The clan contains the following 12 members:

IGR NCD1 SAM_1 SAM_2 SAM_3 SAM_4 SAM_DrpA SAM_Exu SAM_KSR1 SAM_LFY SAM_PNT SAM_Ste50p

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(55)
Full
(36162)
Representative proteomes UniProt
(67470)
RP15
(4509)
RP35
(12571)
RP55
(31560)
RP75
(44103)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

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  Seed
(55)
Full
(36162)
Representative proteomes UniProt
(67470)
RP15
(4509)
RP35
(12571)
RP55
(31560)
RP75
(44103)
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(55)
Full
(36162)
Representative proteomes UniProt
(67470)
RP15
(4509)
RP35
(12571)
RP55
(31560)
RP75
(44103)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: [1],[2]
Previous IDs: SAM_1;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 55
Number in full: 36162
Average length of the domain: 63.10 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 9.08 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.0 23.0
Trusted cut-off 23.0 23.0
Noise cut-off 22.9 22.9
Model length: 64
Family (HMM) version: 32
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SAM_1 domain has been found. There are 131 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JVW6 View 3D Structure Click here
A0A0G2JY48 View 3D Structure Click here
A0A0G2K2B0 View 3D Structure Click here
A0A0G2K2K4 View 3D Structure Click here
A0A0G2K383 View 3D Structure Click here
A0A0G2K383 View 3D Structure Click here
A0A0G2K483 View 3D Structure Click here
A0A0G2K745 View 3D Structure Click here
A0A0G2K781 View 3D Structure Click here
A0A0G2K781 View 3D Structure Click here
A0A0G2K7I9 View 3D Structure Click here
A0A0G2L6L8 View 3D Structure Click here
A0A0G2L938 View 3D Structure Click here
A0A0J9YJ57 View 3D Structure Click here
A0A0J9YJ57 View 3D Structure Click here
A0A0P0W9R6 View 3D Structure Click here
A0A0P0XNK3 View 3D Structure Click here
A0A0R0F0P9 View 3D Structure Click here
A0A0R4IAT9 View 3D Structure Click here
A0A0R4IFY9 View 3D Structure Click here
A0A0R4IGS7 View 3D Structure Click here
A0A0R4IGS7 View 3D Structure Click here
A0A0R4ILL4 View 3D Structure Click here
A0A0R4IQU4 View 3D Structure Click here
A0A0R4IR05 View 3D Structure Click here
A0A140LH27 View 3D Structure Click here
A0A1B0GWS0 View 3D Structure Click here
A0A1B0GWS0 View 3D Structure Click here
A0A1D6E8Z1 View 3D Structure Click here
A0A1D6EBW3 View 3D Structure Click here
A0A1D6EQY9 View 3D Structure Click here
A0A1D6GD80 View 3D Structure Click here
A0A1D6H9K4 View 3D Structure Click here
A0A1D6J894 View 3D Structure Click here
A0A1D8PGY4 View 3D Structure Click here
A0A286Y9G2 View 3D Structure Click here
A0A2R8PXA7 View 3D Structure Click here
A0A2R8PZF7 View 3D Structure Click here
A0A2R8Q205 View 3D Structure Click here
A0A2R8Q6P7 View 3D Structure Click here
A0A2R8QAS9 View 3D Structure Click here
A0A2R8QFA2 View 3D Structure Click here
A0A2R8QG72 View 3D Structure Click here
A0A2R8QHE3 View 3D Structure Click here
A0A2R8QJW7 View 3D Structure Click here
A0A2R8QSI6 View 3D Structure Click here
A0A2R8QSQ5 View 3D Structure Click here
A0A2R8RM95 View 3D Structure Click here
A2A5N8 View 3D Structure Click here
A2AV32 View 3D Structure Click here
A2CEJ3 View 3D Structure Click here
A5PMU4 View 3D Structure Click here
A5PMU4 View 3D Structure Click here
A8DYM0 View 3D Structure Click here
A8DYM0 View 3D Structure Click here
A8E7C9 View 3D Structure Click here
A8JQ65 View 3D Structure Click here
A8WG10 View 3D Structure Click here
A9C3W3 View 3D Structure Click here
A9C3W3 View 3D Structure Click here
B0S4Y7 View 3D Structure Click here
B0S6H8 View 3D Structure Click here
B0S6H8 View 3D Structure Click here
B1B1A0 View 3D Structure Click here
B2RXQ2 View 3D Structure Click here
B2RXQ2 View 3D Structure Click here
B4F8L5 View 3D Structure Click here
B4FCW3 View 3D Structure Click here
B5DF21 View 3D Structure Click here
B5DFK2 View 3D Structure Click here
B6SGQ2 View 3D Structure Click here
B6TGT5 View 3D Structure Click here
B7WN72 View 3D Structure Click here
B8QI36 View 3D Structure Click here
B8QI36 View 3D Structure Click here
D3YUG0 View 3D Structure Click here
D3YXK1 View 3D Structure Click here
D3YZU1 View 3D Structure Click here
D3ZBN3 View 3D Structure Click here
D3ZDH4 View 3D Structure Click here
D3ZDJ9 View 3D Structure Click here
D3ZH39 View 3D Structure Click here
D3ZI42 View 3D Structure Click here
D3ZJ91 View 3D Structure Click here
D3ZJT9 View 3D Structure Click here
D3ZKC5 View 3D Structure Click here
D3ZLM9 View 3D Structure Click here
D3ZMX5 View 3D Structure Click here
D3ZRB1 View 3D Structure Click here
D3ZRL8 View 3D Structure Click here
D3ZTY5 View 3D Structure Click here
D3ZVD1 View 3D Structure Click here
D3ZWK4 View 3D Structure Click here
D4A0M3 View 3D Structure Click here
D4A5C9 View 3D Structure Click here
D4A769 View 3D Structure Click here
D4A9T0 View 3D Structure Click here
D4A9T0 View 3D Structure Click here
D4AC12 View 3D Structure Click here
D4AC12 View 3D Structure Click here
E7F2W4 View 3D Structure Click here
E7F345 View 3D Structure Click here
E7F4T8 View 3D Structure Click here
E7F533 View 3D Structure Click here
E7F641 View 3D Structure Click here
E7F6B2 View 3D Structure Click here
E7F857 View 3D Structure Click here
E7FAZ0 View 3D Structure Click here
E7FBA1 View 3D Structure Click here
E7FBN5 View 3D Structure Click here
E7FEN0 View 3D Structure Click here
E9QEX7 View 3D Structure Click here
F1LM60 View 3D Structure Click here
F1LU97 View 3D Structure Click here
F1M8A4 View 3D Structure Click here
F1M8A4 View 3D Structure Click here
F1M8A7 View 3D Structure Click here
F1Q505 View 3D Structure Click here
F1Q6P6 View 3D Structure Click here
F1Q795 View 3D Structure Click here
F1Q9C9 View 3D Structure Click here
F1Q9S7 View 3D Structure Click here
F1QB48 View 3D Structure Click here
F1QB48 View 3D Structure Click here
F1QBQ0 View 3D Structure Click here
F1QBQ0 View 3D Structure Click here
F1QDB1 View 3D Structure Click here
F1QDB1 View 3D Structure Click here
F1QE28 View 3D Structure Click here
F1QFJ6 View 3D Structure Click here
F1QG75 View 3D Structure Click here
F1QII0 View 3D Structure Click here
F1QII0 View 3D Structure Click here
F1QSD6 View 3D Structure Click here
F1QWA8 View 3D Structure Click here
F1R0Q7 View 3D Structure Click here
F1R3Z4 View 3D Structure Click here
F1RA47 View 3D Structure Click here
F1RBX4 View 3D Structure Click here
F1RCL1 View 3D Structure Click here
F1RDU3 View 3D Structure Click here
F6P2R0 View 3D Structure Click here
F6P3V1 View 3D Structure Click here
F6XZJ7 View 3D Structure Click here
G3V8Q8 View 3D Structure Click here
G5EEW9 View 3D Structure Click here
G9CGD6 View 3D Structure Click here
H2KZC9 View 3D Structure Click here
I1J5E8 View 3D Structure Click here
I1JBX6 View 3D Structure Click here
I1JLJ2 View 3D Structure Click here
I1JYE9 View 3D Structure Click here
I1K8I7 View 3D Structure Click here
I1KB42 View 3D Structure Click here
I1KZ55 View 3D Structure Click here
I1MMM7 View 3D Structure Click here
I3ITP1 View 3D Structure Click here
K7KS72 View 3D Structure Click here
K7L4B5 View 3D Structure Click here
M0R805 View 3D Structure Click here
M0RBX2 View 3D Structure Click here
M0RDA4 View 3D Structure Click here
M9NFI9 View 3D Structure Click here
O09127 View 3D Structure Click here
O15357 View 3D Structure Click here
O35711 View 3D Structure Click here
O35711 View 3D Structure Click here
O62258 View 3D Structure Click here
O64649 View 3D Structure Click here
O73875 View 3D Structure Click here
O73878 View 3D Structure Click here
O75145 View 3D Structure Click here
O75145 View 3D Structure Click here
O75334 View 3D Structure Click here
O75334 View 3D Structure Click here
O75335 View 3D Structure Click here
O75335 View 3D Structure Click here
O75995 View 3D Structure Click here
O76699 View 3D Structure Click here
O94830 View 3D Structure Click here
O94885 View 3D Structure Click here
P09759 View 3D Structure Click here
P0C0T2 View 3D Structure Click here
P0C6S7 View 3D Structure Click here
P0C6S7 View 3D Structure Click here
P21709 View 3D Structure Click here
P29317 View 3D Structure Click here
P29321 View 3D Structure Click here
P29322 View 3D Structure Click here
P29323 View 3D Structure Click here
P54753 View 3D Structure Click here
P54754 View 3D Structure Click here
P54756 View 3D Structure Click here
P54757 View 3D Structure Click here
P54758 View 3D Structure Click here
P54759 View 3D Structure Click here
P54760 View 3D Structure Click here
P54762 View 3D Structure Click here
P54763 View 3D Structure Click here
P59672 View 3D Structure Click here
P59808 View 3D Structure Click here
P60469 View 3D Structure Click here
P60469 View 3D Structure Click here
P78364 View 3D Structure Click here
Q03145 View 3D Structure Click here
Q08C88 View 3D Structure Click here
Q0JDT6 View 3D Structure Click here
Q13136 View 3D Structure Click here
Q13136 View 3D Structure Click here
Q18662 View 3D Structure Click here
Q18662 View 3D Structure Click here
Q1LUM4 View 3D Structure Click here
Q1LUM4 View 3D Structure Click here
Q1RNF8 View 3D Structure Click here
Q20696 View 3D Structure Click here
Q21049 View 3D Structure Click here
Q21049 View 3D Structure Click here
Q21593 View 3D Structure Click here
Q23972 View 3D Structure Click here
Q24009 View 3D Structure Click here
Q2I6J0 View 3D Structure Click here
Q2I6J1 View 3D Structure Click here
Q2QQY1 View 3D Structure Click here
Q3V1H9 View 3D Structure Click here
Q495M9 View 3D Structure Click here
Q4ACU6 View 3D Structure Click here
Q4D1U1 View 3D Structure Click here
Q4DGE0 View 3D Structure Click here
Q4DXY3 View 3D Structure Click here
Q52K85 View 3D Structure Click here
Q54B63 View 3D Structure Click here
Q54F01 View 3D Structure Click here
Q54LW4 View 3D Structure Click here
Q54XT3 View 3D Structure Click here
Q54XX5 View 3D Structure Click here
Q55A55 View 3D Structure Click here
Q55FH8 View 3D Structure Click here
Q5DTW2 View 3D Structure Click here
Q5FWS6 View 3D Structure Click here
Q5FWS6 View 3D Structure Click here
Q5JZY3 View 3D Structure Click here
Q5M9H0 View 3D Structure Click here
Q5PQN2 View 3D Structure Click here
Q5PRF9 View 3D Structure Click here
Q5SGD7 View 3D Structure Click here
Q5T7B8 View 3D Structure Click here
Q5TGI4 View 3D Structure Click here
Q5TZ25 View 3D Structure Click here
Q5TZ25 View 3D Structure Click here
Q5TZ33 View 3D Structure Click here
Q5VSJ4 View 3D Structure Click here
Q5VUG0 View 3D Structure Click here
Q5VXD3 View 3D Structure Click here
Q5XJ13 View 3D Structure Click here
Q60750 View 3D Structure Click here
Q61772 View 3D Structure Click here
Q62413 View 3D Structure Click here
Q64028 View 3D Structure Click here
Q641X0 View 3D Structure Click here
Q674X7 View 3D Structure Click here
Q674X7 View 3D Structure Click here
Q68DC2 View 3D Structure Click here
Q69ZS8 View 3D Structure Click here
Q69ZS8 View 3D Structure Click here
Q6GMG7 View 3D Structure Click here
Q6GQX6 View 3D Structure Click here
Q6NZC7 View 3D Structure Click here
Q6P549 View 3D Structure Click here
Q6P9H4 View 3D Structure Click here
Q6P9K8 View 3D Structure Click here
Q6P9K8 View 3D Structure Click here
Q6S004 View 3D Structure Click here
Q6SPF0 View 3D Structure Click here
Q6ZW76 View 3D Structure Click here
Q7F1E2 View 3D Structure Click here
Q7JQG5 View 3D Structure Click here
Q7JQG5 View 3D Structure Click here
Q7JQL2 View 3D Structure Click here
Q7KNQ9 View 3D Structure Click here
Q7X7Y6 View 3D Structure Click here
Q7Z3H4 View 3D Structure Click here
Q7Z6G8 View 3D Structure Click here
Q7Z6G8 View 3D Structure Click here
Q80T11 View 3D Structure Click here
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