Summary: Adenoviral fibre protein (knob domain)
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Adenoviral fibre protein (knob domain) Provide feedback
Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.
Xia D, Henry LJ, Gerard RD, Deisenhofer J; , Structure 1994;2:1259-1270.: Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution. PUBMED:7704534 EPMC:7704534
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This tab holds annotation information from the InterPro database.
InterPro entry IPR000978Adenoviruses are responsible for diseases such as pneumonia, cystitis, conjunctivitis and diarrhoea, all of which can be fatal to patients who are immunocompromised [PUBMED:7704534]. Viral infection commences with recognition of host cell receptors by means of specialised proteins on viral surfaces. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.
|Biological process||cell adhesion (GO:0007155)|
|viral attachment to host cell (GO:0019062)|
|viral infectious cycle (GO:0019058)|
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Curation and family details
|Number in seed:||46|
|Number in full:||374|
|Average length of the domain:||176.00 aa|
|Average identity of full alignment:||40 %|
|Average coverage of the sequence by the domain:||50.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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There are 3 interactions for this family. More...
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Adeno_knob domain has been found. There are 144 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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