# STOCKHOLM 1.0 #=GF ID Formyl_trans_N #=GF AC PF00551.20 #=GF DE Formyl transferase #=GF PI formyl_transf; #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE SCOP #=GF GA 26.10 26.10; #=GF TC 26.10 26.20; #=GF NC 26.00 26.00; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 1522592 #=GF RT Crystal structure of glycinamide ribonucleotide transformylase #=GF RT from Escherichia coli at 3.0 A resolution. A target enzyme for #=GF RT chemotherapy. #=GF RA Chen P, Schulze-Gahmen U, Stura EA, Inglese J, Johnson DL, #=GF RA Marolewski A, Benkovic SJ, Wilson IA; #=GF RL J Mol Biol 1992;227:283-292. #=GF DR INTERPRO; IPR002376; #=GF DR SCOP; 1gar; fa; #=GF DR PROSITE; PDOC00319; #=GF DR HOMSTRAD; formyl_transf; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This family includes the following members. Glycinamide #=GF CC ribonucleotide transformylase catalyses the third step in de #=GF CC novo purine biosynthesis, the transfer of a formyl group to #=GF CC 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase #=GF CC produces formate from formyl- tetrahydrofolate. Methionyl-tRNA #=GF CC formyltransferase transfers a formyl group onto the amino #=GF CC terminus of the acyl moiety of the methionyl aminoacyl-tRNA. #=GF CC Inclusion of the following members is supported by PSI-blast. #=GF CC HOXX_BRAJA (P31907) contains a related domain of unknown #=GF CC function. PRTH_PORGI (P46071) contains a related domain of #=GF CC unknown function. Y09P_MYCTU (Q50721) contains a related domain #=GF CC of unknown function. #=GF SQ 13 #=GS PURU_ECOLI/85-262 AC P37051.1 #=GS PUR3_YEAST/2-205 AC P04161.1 #=GS PUR2_CHICK/804-984 AC P21872.1 #=GS PUR2_DROME/1154-1336 AC P00967.2 #=GS PUR3_ECOLI/1-181 AC P08179.1 #=GS PUR3_ECOLI/1-181 DR PDB; 1CDE B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1JKX C; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1C3E B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1CDD B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1CDE D; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1CDD A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1GRC A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1CDE C; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1GAR B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1GAR A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1JKX A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1JKX D; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1GRC B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1C2T B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1JKX B; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1C2T A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1C3E A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 3GAR A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 2GAR A; 1-181; #=GS PUR3_ECOLI/1-181 DR PDB; 1CDE A; 1-181; #=GS PUR3_HAEIN/2-182 AC P43846.1 #=GS PUR3_ARATH/78-264 AC P52422.2 #=GS PUR3_BACSU/2-182 AC P12040.2 #=GS AL1L1_RAT/1-180 AC P28037.3 #=GS AL1L1_RAT/1-180 DR PDB; 1S3I A; 1-180; #=GS FMT_THET8/1-179 AC Q5SLH3.1 #=GS FMT_YEAST/30-232 AC P32785.2 #=GS FMT_ECOLI/5-184 AC P23882.4 #=GS FMT_ECOLI/5-184 DR PDB; 1FMT B; 4-183; #=GS FMT_ECOLI/5-184 DR PDB; 1FMT A; 4-183; #=GS FMT_ECOLI/5-184 DR PDB; 2FMT A; 4-183; #=GS FMT_ECOLI/5-184 DR PDB; 2FMT B; 4-183; #=GS FMT_HAEIN/1-183 AC P44787.1 PURU_ECOLI/85-262 RRIVILVTKEAHCLGDL.LMKANYGGLD...VEIAAVIGNHDTLR..SLVERFDIPFELVSHEG...................LTRN..EHDQKMADAIDAYQPDYVVLAKYMRVLTPEFV.ARFPNKIINIHHSFLPAF.....IG.ARPYHQAYERGVKI.....IGATAHYVN.DNLDEGPIIMQDVIHVDH.TYTAEDMMRAGRDVEK.NVLSRAL #=GR PURU_ECOLI/85-262 pAS ....................................................................................................................................*....................................................................................... #=GR PURU_ECOLI/85-262 sAS ....................................................................................................................................................................................*....................................... PUR3_YEAST/2-205 ARIVVLISGSGSNLQAL.IDAQKQGQLGE.DAHIVSVISSSKKAYGLTRAADNNIPTKVCSLYPYTKGIA......KEDKAARAKAR.SQFENDLAKLVLEEKPDVIICAGWLLILGSTFLSQLQSVPILNLHPALPGCF.....DGTTHAIEMAWRKCQDENKPLTAGCMVHYVI.EEVDKGEPLVVKKLEIIPGEETLEQYEQRVHDAEH.IAIVEAT #=GR PUR3_YEAST/2-205 pAS ....................................................................................................................................*....................................................................................... PUR2_CHICK/804-984 VKVAVLISGTGTNLEAL.INSTKKPTSF...AEIVLVVSNKAGVEGLRKAERAGIPTRVIDHKQ...................YGSR.TEFDSAVDRVLEEFSVELICLAGFMRILSGPFV.KKWEGKILNIHPSLLPSF.....KG.ANAHKLVLEAGVRV.....TGCTVHFVA.EEVDAGAIIFQEAVPVKI.GDTVETLSERVKEAEH.RAFPAAL #=GR PUR2_CHICK/804-984 pAS ....................................................................................................................................*....................................................................................... PUR2_DROME/1154-1336 KRVAVLISGTGSNLQAL.IDATRDSAQGI.HADVVLVISNKPGVLGLQRATQAGIPSLVISHKD...................FASR.EVYDAELTRNLKAARVDLICLAGFMRVLSAPFV.REWRGRLVNIHPSLLPKY.....PG.LHVQKQALEAGEKE.....SGCTVHFVD.EGVDTGAIIVQAAVPILP.DDDEDSLTQRIHKAEH.WAFPRAL #=GR PUR2_DROME/1154-1336 pAS ....................................................................................................................................*....................................................................................... PUR3_ECOLI/1-181 MNIVVLISGNGSNLQAI.IDACKTNKIK...GTVRAVFSNKADAFGLERARQAGIATHTLIASA...................FDSR.EAYDRELIHEIDMYAPDVVVLAGFMRILSPAFV.SHYAGRLLNIHPSLLPKY.....PG.LHTHRQALENGDEE.....HGTSVHFVT.DELDGGPVILQAKVPVFA.GDSEDDITARVQTQEH.AIYPLVI #=GR PUR3_ECOLI/1-181 SS -EEEEEESSS-HHHHHH.HHHHHTTSSS...SEEEEEEESSTT-HHHHHHHHTT-EEEE--GGG...................SSSH.HHHHHHHHHHHGGG--SEEEESS--S---HHHH.HHTTTSEEEEESSSTTSS.....-S.S-HHHHHHHTTSSE.....EEEEEEE--.SSTTTS-EEEEEEEE--T.T--HHHHHHHHHHHHH.HHHHHHH #=GR PUR3_ECOLI/1-181 AS ....................................................................................................................................*....................................................................................... PUR3_HAEIN/2-182 KKIAVLISGQGTNLQTI.IDACHSGDIP...AKIACVISNKADAYGLVRAKQAQIPQAVFLRKN...................FSNN.LEMDDAIGDYLQSLAVDLIVLAGYMKILTPKFT.QRFAGKILNIHPSLLPKY.....AG.LNTYQRAIEAGDNE.....HGTTVHFVN.EEVDGGAIVLQAKVPIFP.EDSIEEVEARTREQEY.QIYPLVI #=GR PUR3_HAEIN/2-182 pAS ....................................................................................................................................*....................................................................................... PUR3_ARATH/78-264 KKLAVFVSGGGSNFRKI.HEGCSDGSVN...GDVVLLVTNKKDCGGAEYARSNGIPVLVFPKAK...................REPSDGLSPSELVDVLRKYGVDFVLLAGYLKLIPVELV.QAFPKRILNIHPALLPAFGGKGLYG.IKVHKAVLESGARY.....SGPTIHFVN.EEYDTGRILAQSAVRVIA.NDTPEELAKRVLHEEH.KLYVEVV #=GR PUR3_ARATH/78-264 pAS ....................................................................................................................................*....................................................................................... PUR3_BACSU/2-182 KKFAVFASGNGSNFEAI.VTRLKEENWD...ASAALLVCDKPQAKVIERAEAFHIPSFAFEPKS...................YENK.AAFEQAIIEQLRLHEVELIALAGYMRLIGDTLL.QAYGGKIINIHPSLLPAF.....PG.IDAVGQAFRAGVKV.....AGITVHYVD.EGMDTGPIIAQKAIEIDE.HDTLETIEQRIHKLEH.KWYPSVI #=GR PUR3_BACSU/2-182 pAS ....................................................................................................................................*....................................................................................... AL1L1_RAT/1-180 MKIAVI..GQSLFGQEV.YCQLRKEGHE...VVGVFTIPDKDGKADPLGLEAEKDGVPVFKFPR...................WRAR.GQALPEVVAKYQALGAELNVLPFCSQFIPMEVI.NAPRHGSIIYHPSLLPRH.....RG.ASAINWTLIHGDKK.....GGFTIFWAD.DGLDTGDLLLQKECEVLP.DDTVSTLYNRFLFPEGIKGMVQAV #=GR AL1L1_RAT/1-180 SS -EEEEE..E-SHHHHHH.HHHHHHTT-E...EEEEE----BTTB--HHHHHHHHHT--EE--S-...................SEET.TEE-HHHHHHHHTT--SEEEEEE--S---HHHH.SSSTT-EEEEESS-TTTT.....BS.S-HHHHHHHTT-SE.....EEEEEEE--.SSSS-S-EEEEEEEE--T.T--HHHHHHHTHHHHHHHHHHHHH #=GR AL1L1_RAT/1-180 pAS ....................................................................................................................................*....................................................................................... FMT_THET8/1-179 MRVAFF..GTPLWAVPV.LDALRKRHQ......VVLVVSQPDKPQGRGLRPAPSPVARYAEAEGL................PLLRPA.RLREEAFLEALRQAAPEVAVVAAYGKLIPKEAL.DIPPHGFLNLHPSLLPKY.....RG.AAPVQRALLAGERE.....TGVSIMRLD.EGLDTGPLYAVWRTPILP.DEDAVALGNRLRDKGV.ELLLEVL #=GR FMT_THET8/1-179 pAS ....................................................................................................................................*....................................................................................... FMT_YEAST/30-232 LNVLFFGSDTFSNFSLQALNELRQNNGSCGIVDNIQVVTRSPKWCGRQKSILKYPPIFDMAEKLQLPRPITCDTKQEMLALSKLTPS.RQGNPENDGSGAPFNA..IIAVSFGKLIPGDLI.RAVPL.ALNVHPSLLPRH.....KG.SAPIQRALLEGDTY.....TGVTIQTLHPDRFDHGAIVAQTEPLAIATMLSKGRVNDSTADFNS.EGLPRRT #=GR FMT_YEAST/30-232 pAS ....................................................................................................................................*....................................................................................... FMT_ECOLI/5-184 LRIIFA..GTPDFAARH.LDALLSSGHN.....VVGVFTQPDRPAGRGKKLMPSPVKVLAEEKGL................PVFQPV.SLRPQENQQLVAELQADVMVVVAYGLILPKAVL.EMPRLGCINVHGSLLPRW.....RG.AAPIQRSLWAGDAE.....TGVTIMQMD.VGLDTGDMLYKLSCPITA.EDTSGTLYDKLAELGP.QGLITTL #=GR FMT_ECOLI/5-184 SS -EEEEE..E-SHHHHHH.HHHHHHTT-E.....EEEEE----EE-SSS--EE--HHHHHHHHCT-................-EE--S.-SSSHHHHHHHHCTT-SEEEEES--S---HHHH.HSSTT-EEEEESSSTTTT.....BS.S-HHHHHHHTT-SE.....EEEEEEE--.SSSS-S-EEEEEEEE--T.T--HHHHHHHHHHHHH.HHHHHHH #=GR FMT_ECOLI/5-184 pAS ....................................................................................................................................*....................................................................................... FMT_HAEIN/1-183 MKSLNIIFAGTPDFAAQ.HLQAILNSQH....NVIAVYTQPDKPAGRGKKLQASPVKQLAEQNNI................PVYQPK.SLRKEEAQSELKALNADVMVVVAYGLILPKAVL.DAPRLGCLNVHGSILPRW.....RG.AAPIQRSIWAGDVQ.....TGVTIMQMD.EGLDTGDMLHKVYCDILP.TETSTSLYNKLAELAP.SALIDVL #=GR FMT_HAEIN/1-183 pAS ....................................................................................................................................*....................................................................................... #=GC SS_cons -EEEEEESESSHHHHHH.HHHHHHTTSE...CEEEEEEESCTTEHCHHHHHHCCHCCCECHHCC-................-ESCCC.CCCCHHHHHHHHCTT-SEEEEES--S---HHHH.HSSTTSEEEEESSSTTTT.....BS.S-HHHHHHHTTSSE.....EEEEEEE--.SSSSTS-EEEEEEEE--T.T--HHHHHHHHHHHHHHHHHHHHH #=GC seq_cons h+lsVllSGsuoNhpsl.lsut+psshs...spllhVlos+scstGhp+uppssIPshlhppcs...................apsp.pth-p-lsctlcthssDlllLAuah+lLssshl.pthsttlLNlHPSLLP+a.....tG.ssshppALcuG-cp.....sGsTlHaVs.EtlDsGsllhQttl.lhs.sDTh-sltpRlp-hEp.pshspsl //