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186  structures 1456  species 0  interactions 87659  sequences 2715  architectures

Family: BTB (PF00651)

Summary: BTB/POZ domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "BTB/POZ domain". More...

BTB/POZ domain Edit Wikipedia article

BTB/POZ domain
PDB 1buo EBI.jpg
Structure of the BTB domain from PLZF.[1]
Identifiers
Symbol BTB
Pfam PF00651
InterPro IPR013069
PROSITE PS50097
SCOP 1buo
SUPERFAMILY 1buo

The BTB/POZ domain is a common structural domain contained within some proteins.

The BTB (for BR-C, ttk and bab)[2] or POZ (for Pox virus and Zinc finger)[3] domain is present near the N-terminus of a fraction of zinc finger proteins and in proteins that contain the Kelch motif and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation.[3] The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule.[1] BTB/POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT.[4][5][6] The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

References

  1. ^ a b Ahmad KF, Engel CK, Privé GG (October 1998). "Crystal structure of the BTB domain from PLZF". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12123–8. doi:10.1073/pnas.95.21.12123. PMC 22795Freely accessible. PMID 9770450. 
  2. ^ Zollman S, Godt D, Privé GG, Couderc JL, Laski FA (October 1994). "The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10717–21. doi:10.1073/pnas.91.22.10717. PMC 45093Freely accessible. PMID 7938017. 
  3. ^ a b Bardwell VJ, Treisman R (July 1994). "The POZ domain: a conserved protein-protein interaction motif". Genes Dev. 8 (14): 1664–77. doi:10.1101/gad.8.14.1664. PMID 7958847. 
  4. ^ Deweindt C, Albagli O, Bernardin F, Dhordain P, Quief S, Lantoine D, Kerckaert JP, Leprince D (December 1995). "The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain". Cell Growth Differ. 6 (12): 1495–503. PMID 9019154. 
  5. ^ Huynh KD, Bardwell VJ (November 1998). "The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT". Oncogene. 17 (19): 2473–84. doi:10.1038/sj.onc.1202197. PMID 9824158. 
  6. ^ Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306. 

This article incorporates text from the public domain Pfam and InterPro IPR013069

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BTB/POZ domain Provide feedback

The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (PF00096) proteins and in proteins that contain the PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Literature references

  1. Zollman S, Godt D, Prive GG, Couderc JL, Laski FA; , Proc Natl Acad Sci U S A 1994;91:10717-10721.: The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. PUBMED:7938017 EPMC:7938017

  2. Bardwell VJ, Treisman R; , Genes Dev 1994;8:1664-1677.: The POZ domain: a conserved protein-protein interaction motif. PUBMED:7958847 EPMC:7958847

  3. Ahmad KF, Engel CK, Prive GG; , Proc Natl Acad Sci U S A 1998;95:12123-12128.: Crystal structure of the BTB domain from PLZF. PUBMED:9770450 EPMC:9770450

  4. Deweindt C, Albagli O, Bernardin F, Dhordain P, Quief S, Lantoine D, Kerckaert JP, Leprince D; , Cell Growth Differ 1995;6:1495-1503.: The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. PUBMED:9019154 EPMC:9019154

  5. Huynh KD, Bardwell VJ; , Oncogene 1998;17:2473-2484.: The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. PUBMED:9824158 EPMC:9824158

  6. Wong CW, Privalsky ML; , J Biol Chem 1998;273:27695-27702.: Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. PUBMED:9765306 EPMC:9765306

  7. Stogios PJ, Downs GS, Jauhal JJ, Nandra SK, Prive GG; , Genome Biol. 2005;6:R82.: Sequence and structural analysis of BTB domain proteins. PUBMED:16207353 EPMC:16207353


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000210

The BTB domain (Broad-Complex, Tramtrack and Bric a brac) is also known as the POZ domain (POxvirus and Zinc finger). It is a homodimerization domain occurring at the N terminus of proteins containing multiple copies of either zinc fingers of the C2H2 type or Kelch repeats [ PUBMED:7938017 , PUBMED:7958847 ]. Many BTB proteins are transcriptional regulators that are thought to act through the control of chromatin structure.

The structure of the BTB domain of the promyelocytic leukemia zinc finger (PLZF) protein has been determined by X-ray crystallography and reveals a tightly intertwined dimer with an extensive hydrophobic interface [ PUBMED:9770450 ]. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan POZ (CL0033), which has the following description:

The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.

The clan contains the following 6 members:

BACK BTB BTB_2 BTB_3 DUF3342 Skp1_POZ

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(83)
Full
(87659)
Representative proteomes UniProt
(152057)
RP15
(17617)
RP35
(40077)
RP55
(75228)
RP75
(98011)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(83)
Full
(87659)
Representative proteomes UniProt
(152057)
RP15
(17617)
RP35
(40077)
RP55
(75228)
RP75
(98011)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(83)
Full
(87659)
Representative proteomes UniProt
(152057)
RP15
(17617)
RP35
(40077)
RP55
(75228)
RP75
(98011)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Bardwell VJ
Number in seed: 83
Number in full: 87659
Average length of the domain: 106.10 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 20.62 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.5 20.5
Trusted cut-off 20.5 20.5
Noise cut-off 20.4 20.4
Model length: 111
Family (HMM) version: 33
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BTB domain has been found. There are 186 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A023PGP0 View 3D Structure Click here
A0A060CZD5 View 3D Structure Click here
A0A060D7E9 View 3D Structure Click here
A0A087WR44 View 3D Structure Click here
A0A087WSN2 View 3D Structure Click here
A0A0A0MQP3 View 3D Structure Click here
A0A0A6YWS7 View 3D Structure Click here
A0A0A6YXL2 View 3D Structure Click here
A0A0A6YY25 View 3D Structure Click here
A0A0G2JT85 View 3D Structure Click here
A0A0G2JTF3 View 3D Structure Click here
A0A0G2JVJ2 View 3D Structure Click here
A0A0G2JWZ1 View 3D Structure Click here
A0A0G2JZT4 View 3D Structure Click here
A0A0G2K031 View 3D Structure Click here
A0A0G2K0X7 View 3D Structure Click here
A0A0G2K102 View 3D Structure Click here
A0A0G2K3D7 View 3D Structure Click here
A0A0G2K427 View 3D Structure Click here
A0A0G2K4P9 View 3D Structure Click here
A0A0G2K533 View 3D Structure Click here
A0A0G2K7D6 View 3D Structure Click here
A0A0G2K852 View 3D Structure Click here
A0A0G2K982 View 3D Structure Click here
A0A0G2K9E3 View 3D Structure Click here
A0A0G2K9E3 View 3D Structure Click here
A0A0G2KAA6 View 3D Structure Click here
A0A0G2KB38 View 3D Structure Click here
A0A0G2KCC7 View 3D Structure Click here
A0A0G2KCH4 View 3D Structure Click here
A0A0G2L3U3 View 3D Structure Click here
A0A0K3AS98 View 3D Structure Click here
A0A0N4STP4 View 3D Structure Click here
A0A0N7KP81 View 3D Structure Click here
A0A0N7KRT6 View 3D Structure Click here
A0A0P0VI73 View 3D Structure Click here
A0A0P0VL49 View 3D Structure Click here
A0A0P0W204 View 3D Structure Click here
A0A0P0WEY4 View 3D Structure Click here
A0A0P0WM47 View 3D Structure Click here
A0A0P0X026 View 3D Structure Click here
A0A0P0XBF9 View 3D Structure Click here
A0A0P0XBI2 View 3D Structure Click here
A0A0P0XCU9 View 3D Structure Click here
A0A0P0XD24 View 3D Structure Click here
A0A0P0XDF6 View 3D Structure Click here
A0A0P0XDJ3 View 3D Structure Click here
A0A0P0XE17 View 3D Structure Click here
A0A0P0XHP7 View 3D Structure Click here
A0A0P0XHT9 View 3D Structure Click here
A0A0P0XHU1 View 3D Structure Click here
A0A0P0XHY3 View 3D Structure Click here
A0A0P0XI87 View 3D Structure Click here
A0A0P0XUD3 View 3D Structure Click here
A0A0P0XUH8 View 3D Structure Click here
A0A0P0XUI3 View 3D Structure Click here
A0A0P0XUU8 View 3D Structure Click here
A0A0P0XUZ3 View 3D Structure Click here
A0A0P0XVC1 View 3D Structure Click here
A0A0P0Y4J8 View 3D Structure Click here
A0A0P0Y4J8 View 3D Structure Click here
A0A0R0EAT7 View 3D Structure Click here
A0A0R0ECU3 View 3D Structure Click here
A0A0R0EEG7 View 3D Structure Click here
A0A0R0EIF6 View 3D Structure Click here
A0A0R0EJ93 View 3D Structure Click here
A0A0R0EJL2 View 3D Structure Click here
A0A0R0EMP2 View 3D Structure Click here
A0A0R0ES85 View 3D Structure Click here
A0A0R0EUS4 View 3D Structure Click here
A0A0R0EV96 View 3D Structure Click here
A0A0R0FB25 View 3D Structure Click here
A0A0R0FE97 View 3D Structure Click here
A0A0R0FNB1 View 3D Structure Click here
A0A0R0FXI1 View 3D Structure Click here
A0A0R0GGE3 View 3D Structure Click here
A0A0R0GGE3 View 3D Structure Click here
A0A0R0GSN8 View 3D Structure Click here
A0A0R0HL69 View 3D Structure Click here
A0A0R0HVZ1 View 3D Structure Click here
A0A0R0HWP0 View 3D Structure Click here
A0A0R0IBM0 View 3D Structure Click here
A0A0R0JJD7 View 3D Structure Click here
A0A0R0KCA2 View 3D Structure Click here
A0A0R0KG72 View 3D Structure Click here
A0A0R4IAE5 View 3D Structure Click here
A0A0R4IHV2 View 3D Structure Click here
A0A0R4IK06 View 3D Structure Click here
A0A0R4IKZ8 View 3D Structure Click here
A0A0R4IM01 View 3D Structure Click here
A0A0R4IND3 View 3D Structure Click here
A0A0R4IV61 View 3D Structure Click here
A0A0R4IVZ9 View 3D Structure Click here
A0A0R4IWF3 View 3D Structure Click here
A0A0R4J2B9 View 3D Structure Click here
A0A131MBE3 View 3D Structure Click here
A0A131MD04 View 3D Structure Click here
A0A140LGF5 View 3D Structure Click here
A0A140LGQ1 View 3D Structure Click here
A0A140LGQ1 View 3D Structure Click here
A0A140LGZ3 View 3D Structure Click here
A0A140LGZ3 View 3D Structure Click here
A0A140T8Q5 View 3D Structure Click here
A0A1D6F9J0 View 3D Structure Click here
A0A1D6FQK0 View 3D Structure Click here
A0A1D6G4W8 View 3D Structure Click here
A0A1D6GCK7 View 3D Structure Click here
A0A1D6GQJ4 View 3D Structure Click here
A0A1D6H312 View 3D Structure Click here
A0A1D6H591 View 3D Structure Click here
A0A1D6HWW6 View 3D Structure Click here
A0A1D6HXF9 View 3D Structure Click here
A0A1D6HXK2 View 3D Structure Click here
A0A1D6I280 View 3D Structure Click here
A0A1D6I4G9 View 3D Structure Click here
A0A1D6IKM7 View 3D Structure Click here
A0A1D6IQY9 View 3D Structure Click here
A0A1D6J8S6 View 3D Structure Click here
A0A1D6JRM0 View 3D Structure Click here
A0A1D6KJL7 View 3D Structure Click here
A0A1D6KJL7 View 3D Structure Click here
A0A1D6KW66 View 3D Structure Click here
A0A1D6L7A4 View 3D Structure Click here
A0A1D6LPU4 View 3D Structure Click here
A0A1D6LPU4 View 3D Structure Click here
A0A1D6LXS7 View 3D Structure Click here
A0A1D6LXS7 View 3D Structure Click here
A0A1D6M3M1 View 3D Structure Click here
A0A1D6MHJ2 View 3D Structure Click here
A0A1D6MTD6 View 3D Structure Click here
A0A1D6N1G2 View 3D Structure Click here
A0A1D6N2A2 View 3D Structure Click here
A0A1D6N541 View 3D Structure Click here
A0A1D6NXS3 View 3D Structure Click here
A0A1D6NXS3 View 3D Structure Click here
A0A1D6PTX7 View 3D Structure Click here
A0A1D6PY42 View 3D Structure Click here
A0A1D6PY43 View 3D Structure Click here
A0A1D6QHE6 View 3D Structure Click here
A0A1D6QMW7 View 3D Structure Click here
A0A1D8PMG6 View 3D Structure Click here
A0A1D8PQR6 View 3D Structure Click here
A0A1D8PQR6 View 3D Structure Click here
A0A1D8PU32 View 3D Structure Click here
A0A1W2Q655 View 3D Structure Click here
A0A1X7YIP2 View 3D Structure Click here
A0A286YAJ6 View 3D Structure Click here
A0A286YAJ6 View 3D Structure Click here
A0A286YC09 View 3D Structure Click here
A0A2C9C3D9 View 3D Structure Click here
A0A2I3BRZ3 View 3D Structure Click here
A0A2I3BRZ3 View 3D Structure Click here
A0A2R8PXW6 View 3D Structure Click here
A0A2R8Q0Z4 View 3D Structure Click here
A0A2R8Q1W5 View 3D Structure Click here
A0A2R8Q260 View 3D Structure Click here
A0A2R8Q260 View 3D Structure Click here
A0A2R8Q2Q0 View 3D Structure Click here
A0A2R8Q450 View 3D Structure Click here
A0A2R8Q450 View 3D Structure Click here
A0A2R8Q5T3 View 3D Structure Click here
A0A2R8Q616 View 3D Structure Click here
A0A2R8Q9E7 View 3D Structure Click here
A0A2R8QB83 View 3D Structure Click here
A0A2R8QC39 View 3D Structure Click here
A0A2R8QCA3 View 3D Structure Click here
A0A2R8QCY5 View 3D Structure Click here
A0A2R8QD64 View 3D Structure Click here
A0A2R8QDK2 View 3D Structure Click here
A0A2R8QED8 View 3D Structure Click here
A0A2R8QFH5 View 3D Structure Click here
A0A2R8QFR8 View 3D Structure Click here
A0A2R8QJR9 View 3D Structure Click here
A0A2R8QM13 View 3D Structure Click here
A0A2R8QS60 View 3D Structure Click here
A0A2R8QUM7 View 3D Structure Click here
A0A2R8RYY7 View 3D Structure Click here
A0A368UGL5 View 3D Structure Click here
A0A368UI42 View 3D Structure Click here
A0A571BD55 View 3D Structure Click here
A0A571BG45 View 3D Structure Click here
A0A571BG86 View 3D Structure Click here
A0FLS4 View 3D Structure Click here
A0JMG1 View 3D Structure Click here
A1L4W5 View 3D Structure Click here
A1YPR0 View 3D Structure Click here
A1Z7I5 View 3D Structure Click here
A1ZAE2 View 3D Structure Click here
A1ZAE2 View 3D Structure Click here
A2AAX3 View 3D Structure Click here
A2AI76 View 3D Structure Click here
A2AJX0 View 3D Structure Click here
A2ATY4 View 3D Structure Click here
A2AUC9 View 3D Structure Click here
A2BF92 View 3D Structure Click here
A2BFZ7 View 3D Structure Click here
A2BGW8 View 3D Structure Click here
A2BHG6 View 3D Structure Click here
A2BIA1 View 3D Structure Click here
A2CFD5 View 3D Structure Click here
A2CG71 View 3D Structure Click here
A2CG92 View 3D Structure Click here
A2CGC2 View 3D Structure Click here
A2CIR7 View 3D Structure Click here
A2RRV4 View 3D Structure Click here
A3A605 View 3D Structure Click here
A3C513 View 3D Structure Click here
A4HY26 View 3D Structure Click here
A5PMB0 View 3D Structure Click here
A5WWI3 View 3D Structure Click here
A6NE02 View 3D Structure Click here
A6QL63 View 3D Structure Click here
A7YX59 View 3D Structure Click here
A8DU70 View 3D Structure Click here
A8JR16 View 3D Structure Click here
A9JRD8 View 3D Structure Click here
A9JT69 View 3D Structure Click here
B0G136 View 3D Structure Click here
B0G136 View 3D Structure Click here
B0S619 View 3D Structure Click here
B0V1A3 View 3D Structure Click here
B1AZR0 View 3D Structure Click here
B1H220 View 3D Structure Click here
B1H285 View 3D Structure Click here
B1WBS3 View 3D Structure Click here
B1WBU4 View 3D Structure Click here
B1WC22 View 3D Structure Click here
B2GUV8 View 3D Structure Click here
B2GV04 View 3D Structure Click here
B2RXF5 View 3D Structure Click here
B2RXH4 View 3D Structure Click here
B2RYD9 View 3D Structure Click here
B3DIV9 View 3D Structure Click here
B4F8C0 View 3D Structure Click here
B4F8C5 View 3D Structure Click here
B4F8W8 View 3D Structure Click here
B4F9H2 View 3D Structure Click here
B4FAN5 View 3D Structure Click here
B4FDD4 View 3D Structure Click here
B4FE04 View 3D Structure Click here
B4FKJ5 View 3D Structure Click here
B4FKN4 View 3D Structure Click here
B4FNG2 View 3D Structure Click here
B4FQ32 View 3D Structure Click here
B4FQ78 View 3D Structure Click here
B4FX65 View 3D Structure Click here
B5DEL5 View 3D Structure Click here
B5DFI4 View 3D Structure Click here
B5DFI4 View 3D Structure Click here
B5DFJ8 View 3D Structure Click here
B6SWE0 View 3D Structure Click here
B6TM43 View 3D Structure Click here
B6TV51 View 3D Structure Click here
B6UAA7 View 3D Structure Click here
B7U179 View 3D Structure Click here
B8A0E2 View 3D Structure Click here
B8A0Y1 View 3D Structure Click here
B8A2C0 View 3D Structure Click here
B8A4R1 View 3D Structure Click here
B8JIG8 View 3D Structure Click here
B8JJT0 View 3D Structure Click here
B8JKF6 View 3D Structure Click here
B8JKQ2 View 3D Structure Click here
B8JL75 View 3D Structure Click here
B8XQT5 View 3D Structure Click here
B8XQT7 View 3D Structure Click here
B9DHT4 View 3D Structure Click here
B9F591 View 3D Structure Click here
B9G1V0 View 3D Structure Click here
B9G5V6 View 3D Structure Click here
B9G5V7 View 3D Structure Click here
B9G7V2 View 3D Structure Click here
C0HG55 View 3D Structure Click here
C0HH52 View 3D Structure Click here
C0P3Q2 View 3D Structure Click here
C0P413 View 3D Structure Click here
C0PCF1 View 3D Structure Click here
C0PG79 View 3D Structure Click here
C0PIQ8 View 3D Structure Click here
C4J2C8 View 3D Structure Click here
C9JJ37 View 3D Structure Click here
C9JR72 View 3D Structure Click here
D3YUB6 View 3D Structure Click here
D3YUB6 View 3D Structure Click here
D3Z860 View 3D Structure Click here
D3Z8N4 View 3D Structure Click here
D3Z9A5 View 3D Structure Click here
D3ZA50 View 3D Structure Click here
D3ZAN8 View 3D Structure Click here
D3ZBL2 View 3D Structure Click here
D3ZC02 View 3D Structure Click here
D3ZDP9 View 3D Structure Click here
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