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123  structures 1919  species 0  interactions 19366  sequences 304  architectures

Family: Sulfotransfer_1 (PF00685)

Summary: Sulfotransferase domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Sulfotransferase domain Provide feedback

No Pfam abstract.

Literature references

  1. Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC; , Nat Struct Biol 1997;4:904-908.: Crystal structure of estrogen sulphotransferase. PUBMED:9360604 EPMC:9360604


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000863

This entry includes a range of sulphotransferase proteins including flavonyl 3-sulphotransferase, aryl sulphotransferase, alcohol sulphotransferase, estrogen sulphotransferase and phenol-sulphating phenol sulphotransferase. These enzymes are responsible for the transfer of sulphate groups to specific compounds [ PUBMED:9360604 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan P-loop_NTPase (CL0023), which has the following description:

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].

The clan contains the following 243 members:

6PF2K AAA AAA-ATPase_like AAA_10 AAA_11 AAA_12 AAA_13 AAA_14 AAA_15 AAA_16 AAA_17 AAA_18 AAA_19 AAA_2 AAA_21 AAA_22 AAA_23 AAA_24 AAA_25 AAA_26 AAA_27 AAA_28 AAA_29 AAA_3 AAA_30 AAA_31 AAA_32 AAA_33 AAA_34 AAA_35 AAA_5 AAA_6 AAA_7 AAA_8 AAA_9 AAA_PrkA ABC_ATPase ABC_tran ABC_tran_Xtn Adeno_IVa2 Adenylsucc_synt ADK AFG1_ATPase AIG1 APS_kinase Arf ArsA_ATPase ATP-synt_ab ATP_bind_1 ATP_bind_2 ATPase ATPase_2 Bac_DnaA BCA_ABC_TP_C Beta-Casp bpMoxR Cas_Csn2 Cas_St_Csn2 CbiA CBP_BcsQ CDC73_C CENP-M CFTR_R CLP1_P CMS1 CoaE CobA_CobO_BtuR CobU cobW CPT CSM2 CTP_synth_N Cytidylate_kin Cytidylate_kin2 DAP3 DBINO DEAD DEAD_2 DLIC DNA_pack_C DNA_pack_N DNA_pol3_delta DNA_pol3_delta2 DnaB_C dNK DO-GTPase1 DO-GTPase2 DUF1611 DUF1726 DUF2075 DUF2326 DUF2478 DUF257 DUF2791 DUF2813 DUF3584 DUF463 DUF5906 DUF6079 DUF815 DUF853 DUF87 DUF927 Dynamin_N Dynein_heavy Elong_Iki1 ELP6 ERCC3_RAD25_C Exonuc_V_gamma FeoB_N Fer4_NifH Flavi_DEAD FTHFS FtsK_SpoIIIE G-alpha Gal-3-0_sulfotr GBP GBP_C GTP_EFTU Gtr1_RagA Guanylate_kin GvpD HDA2-3 Helicase_C Helicase_C_2 Helicase_C_4 Helicase_RecD Herpes_Helicase Herpes_ori_bp Herpes_TK HSA HydF_dimer HydF_tetramer Hydin_ADK IIGP IPPT IPT iSTAND IstB_IS21 KAP_NTPase KdpD Kinase-PPPase Kinesin KTI12 LAP1C Lon_2 LpxK MCM MeaB MEDS Mg_chelatase Microtub_bd MipZ MMR_HSR1 MMR_HSR1_C MobB MukB Mur_ligase_M MutS_V Myosin_head NACHT NAT_N NB-ARC NOG1 NTPase_1 NTPase_P4 OPA1_C ORC3_N P-loop_TraG ParA Parvo_NS1 PAXNEB PduV-EutP PhoH PIF1 Ploopntkinase1 Ploopntkinase2 Ploopntkinase3 Podovirus_Gp16 Polyoma_lg_T_C Pox_A32 PPK2 PPV_E1_C PRK PSY3 Rad17 Rad51 Ras RecA ResIII RHD3 RhoGAP_pG1_pG2 RHSP RNA12 RNA_helicase Roc RsgA_GTPase RuvB_N SbcCD_C SecA_DEAD Septin Sigma54_activ_2 Sigma54_activat SKI SMC_N SNF2-rel_dom Spore_III_AA Spore_IV_A SRP54 SRPRB SulA Sulfotransfer_1 Sulfotransfer_2 Sulfotransfer_3 Sulfotransfer_4 Sulfotransfer_5 Sulphotransf SWI2_SNF2 T2SSE T4SS-DNA_transf Terminase_1 Terminase_3 Terminase_6N Terminase_GpA Thymidylate_kin TIP49 TK TniB Torsin TraG-D_C tRNA_lig_kinase TrwB_AAD_bind TsaE UvrB UvrD-helicase UvrD_C UvrD_C_2 Viral_helicase1 VirC1 VirE YqeC Zeta_toxin Zot

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(45)
Full
(19366)
Representative proteomes UniProt
(42225)
RP15
(3831)
RP35
(9166)
RP55
(17618)
RP75
(22681)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(45)
Full
(19366)
Representative proteomes UniProt
(42225)
RP15
(3831)
RP35
(9166)
RP55
(17618)
RP75
(22681)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(45)
Full
(19366)
Representative proteomes UniProt
(42225)
RP15
(3831)
RP35
(9166)
RP55
(17618)
RP75
(22681)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_87 (release 2.1) & Pfam-B_1885 (Release 7.5)
Previous IDs: Sulfotransfer;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Griffiths-Jones SR
Number in seed: 45
Number in full: 19366
Average length of the domain: 223.20 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 62.45 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.0 21.0
Trusted cut-off 21.0 21.0
Noise cut-off 20.9 20.9
Model length: 267
Family (HMM) version: 29
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sulfotransfer_1 domain has been found. There are 123 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4KF40 View 3D Structure Click here
A0A0G2JUM0 View 3D Structure Click here
A0A0G2JUU8 View 3D Structure Click here
A0A0G2JZU5 View 3D Structure Click here
A0A0N7KMX9 View 3D Structure Click here
A0A0N7KPK6 View 3D Structure Click here
A0A0N7KTJ7 View 3D Structure Click here
A0A0P0VN52 View 3D Structure Click here
A0A0P0VYI6 View 3D Structure Click here
A0A0P0W9I4 View 3D Structure Click here
A0A0P0X2K9 View 3D Structure Click here
A0A0P0X929 View 3D Structure Click here
A0A0P0XHM3 View 3D Structure Click here
A0A0P0XI38 View 3D Structure Click here
A0A0P0XKX5 View 3D Structure Click here
A0A0P0XSA8 View 3D Structure Click here
A0A0P0XYQ6 View 3D Structure Click here
A0A0P0XYV1 View 3D Structure Click here
A0A0P0Y179 View 3D Structure Click here
A0A0P0Y2D2 View 3D Structure Click here
A0A0P0Y2R7 View 3D Structure Click here
A0A0P0Y6S6 View 3D Structure Click here
A0A0R4ICJ4 View 3D Structure Click here
A0A0R4IM52 View 3D Structure Click here
A0A0R4IR84 View 3D Structure Click here
A0A0R4IT32 View 3D Structure Click here
A0A1B0GRF0 View 3D Structure Click here
A0A1B0GRF0 View 3D Structure Click here
A0A1D6KZE7 View 3D Structure Click here
A0A1D6KZE7 View 3D Structure Click here
A0A1D6N1I0 View 3D Structure Click here
A0A1D6Q726 View 3D Structure Click here
A0A2R8PXJ4 View 3D Structure Click here
A0A2R8PYZ2 View 3D Structure Click here
A0A2R8Q2T8 View 3D Structure Click here
A0A2R8Q6L2 View 3D Structure Click here
A0A2R8QJJ2 View 3D Structure Click here
A0A2R8QKN1 View 3D Structure Click here
A0A2R8RQ45 View 3D Structure Click here
A1Z9J8 View 3D Structure Click here
A2BGL3 View 3D Structure Click here
A4FUP0 View 3D Structure Click here
A5PM89 View 3D Structure Click here
B0R136 View 3D Structure Click here
B0UXT7 View 3D Structure Click here
B2RVI8 View 3D Structure Click here
B3DIF5 View 3D Structure Click here
B4FCB1 View 3D Structure Click here
B4FQ75 View 3D Structure Click here
B4FSB6 View 3D Structure Click here
B4FVM2 View 3D Structure Click here
B6STJ6 View 3D Structure Click here
B6TRN9 View 3D Structure Click here
B7ZWN4 View 3D Structure Click here
B8A5X2 View 3D Structure Click here
C7J6H1 View 3D Structure Click here
D3YVV6 View 3D Structure Click here
D3Z1W5 View 3D Structure Click here
D3ZD27 View 3D Structure Click here
D3ZD62 View 3D Structure Click here
D3ZDL1 View 3D Structure Click here
D3ZFR1 View 3D Structure Click here
D3ZGJ6 View 3D Structure Click here
D3ZLS2 View 3D Structure Click here
D3ZTA9 View 3D Structure Click here
D3ZYE3 View 3D Structure Click here
D4A9P8 View 3D Structure Click here
D4ABE3 View 3D Structure Click here
D4AC92 View 3D Structure Click here
D4ADX9 View 3D Structure Click here
E7F082 View 3D Structure Click here
E7F3K8 View 3D Structure Click here
E7F3X3 View 3D Structure Click here
E7F734 View 3D Structure Click here
E7F825 View 3D Structure Click here
E7F995 View 3D Structure Click here
F1LNK1 View 3D Structure Click here
F1Q6W9 View 3D Structure Click here
F1QE68 View 3D Structure Click here
F1QIK3 View 3D Structure Click here
F1QME4 View 3D Structure Click here
F1QPA8 View 3D Structure Click here
F1QRK0 View 3D Structure Click here
F1QRN3 View 3D Structure Click here
F1QV04 View 3D Structure Click here
F1QYJ6 View 3D Structure Click here
F1RD72 View 3D Structure Click here
G3V9R3 View 3D Structure Click here
G5E904 View 3D Structure Click here
I1J959 View 3D Structure Click here
I1JTH7 View 3D Structure Click here
I1K213 View 3D Structure Click here
I1KX12 View 3D Structure Click here
I1LHF5 View 3D Structure Click here
I1LLH6 View 3D Structure Click here
I1M0M1 View 3D Structure Click here
I1M0M2 View 3D Structure Click here
I1M0T5 View 3D Structure Click here
I1M0T6 View 3D Structure Click here
I1M8J8 View 3D Structure Click here
I1MXR2 View 3D Structure Click here
K7DYB2 View 3D Structure Click here
K7MDA4 View 3D Structure Click here
K7MDA4 View 3D Structure Click here
K7MDH0 View 3D Structure Click here
K7MM76 View 3D Structure Click here
K7N6K9 View 3D Structure Click here
K7VI28 View 3D Structure Click here
L7N245 View 3D Structure Click here
M0R868 View 3D Structure Click here
M0R952 View 3D Structure Click here
M0RAL6 View 3D Structure Click here
O00204 View 3D Structure Click here
O00338 View 3D Structure Click here
O14792 View 3D Structure Click here
O35310 View 3D Structure Click here
O35400 View 3D Structure Click here
O35403 View 3D Structure Click here
O43704 View 3D Structure Click here
O43916 View 3D Structure Click here
O75897 View 3D Structure Click here
O82330 View 3D Structure Click here
O88199 View 3D Structure Click here
O95803 View 3D Structure Click here
P07631 View 3D Structure Click here
P0CC03 View 3D Structure Click here
P0DMM9 View 3D Structure Click here
P0DMN0 View 3D Structure Click here
P15709 View 3D Structure Click here
P17988 View 3D Structure Click here
P22789 View 3D Structure Click here
P49888 View 3D Structure Click here
P49889 View 3D Structure Click here
P49890 View 3D Structure Click here
P49891 View 3D Structure Click here
P50225 View 3D Structure Click here
P50226 View 3D Structure Click here
P50235 View 3D Structure Click here
P50236 View 3D Structure Click here
P50237 View 3D Structure Click here
P52839 View 3D Structure Click here
P52840 View 3D Structure Click here
P52843 View 3D Structure Click here
P52847 View 3D Structure Click here
P52848 View 3D Structure Click here
P52849 View 3D Structure Click here
P52850 View 3D Structure Click here
P63046 View 3D Structure Click here
P63047 View 3D Structure Click here
P9WGB9 View 3D Structure Click here
Q02353 View 3D Structure Click here
Q06520 View 3D Structure Click here
Q0VBN2 View 3D Structure Click here
Q1L872 View 3D Structure Click here
Q1L873 View 3D Structure Click here
Q1L874 View 3D Structure Click here
Q1L875 View 3D Structure Click here
Q1LWC9 View 3D Structure Click here
Q29RB5 View 3D Structure Click here
Q29YR5 View 3D Structure Click here
Q2QU81 View 3D Structure Click here
Q2QY01 View 3D Structure Click here
Q2R3T7 View 3D Structure Click here
Q2R534 View 3D Structure Click here
Q3UHN9 View 3D Structure Click here
Q3UZZ6 View 3D Structure Click here
Q4TTA0 View 3D Structure Click here
Q505J3 View 3D Structure Click here
Q55GK8 View 3D Structure Click here
Q5GFD5 View 3D Structure Click here
Q5RJQ0 View 3D Structure Click here
Q652W0 View 3D Structure Click here
Q658N2 View 3D Structure Click here
Q673U1 View 3D Structure Click here
Q67VR8 View 3D Structure Click here
Q69RG0 View 3D Structure Click here
Q6DBY9 View 3D Structure Click here
Q6DHH8 View 3D Structure Click here
Q6IMI4 View 3D Structure Click here
Q6IMI6 View 3D Structure Click here
Q6NLV9 View 3D Structure Click here
Q6PH37 View 3D Structure Click here
Q6XQG8 View 3D Structure Click here
Q6YV45 View 3D Structure Click here
Q6ZJP3 View 3D Structure Click here
Q6ZJP5 View 3D Structure Click here
Q7LGC8 View 3D Structure Click here
Q7T2V2 View 3D Structure Click here
Q7XIP6 View 3D Structure Click here
Q7XKJ4 View 3D Structure Click here
Q7ZUS4 View 3D Structure Click here
Q80VR3 View 3D Structure Click here
Q80W66 View 3D Structure Click here
Q80WV3 View 3D Structure Click here
Q80XH4 View 3D Structure Click here
Q86IU8 View 3D Structure Click here
Q8BGL3 View 3D Structure Click here
Q8BKN6 View 3D Structure Click here
Q8BSL4 View 3D Structure Click here
Q8GZ53 View 3D Structure Click here
Q8IZT8 View 3D Structure Click here
Q8IZU8 View 3D Structure Click here
Q8L452 View 3D Structure Click here
Q8L5A7 View 3D Structure Click here
Q8MRE7 View 3D Structure Click here
Q8MRE7 View 3D Structure Click here
Q8NCG5 View 3D Structure Click here
Q8RUC1 View 3D Structure Click here
Q8RUC1 View 3D Structure Click here
Q8RUC1 View 3D Structure Click here
Q8RV79 View 3D Structure Click here
Q91X36 View 3D Structure Click here
Q966W3 View 3D Structure Click here
Q96QI5 View 3D Structure Click here
Q9BR01 View 3D Structure Click here
Q9C9C9 View 3D Structure Click here
Q9C9D0 View 3D Structure Click here
Q9D939 View 3D Structure Click here
Q9EP78 View 3D Structure Click here
Q9EQC0 View 3D Structure Click here
Q9EQH7 View 3D Structure Click here
Q9EQW8 View 3D Structure Click here
Q9ESG5 View 3D Structure Click here
Q9FG94 View 3D Structure Click here
Q9FX55 View 3D Structure Click here
Q9FX56 View 3D Structure Click here
Q9FZ80 View 3D Structure Click here
Q9FZ91 View 3D Structure Click here
Q9GZS9 View 3D Structure Click here
Q9GZX3 View 3D Structure Click here
Q9H3R1 View 3D Structure Click here
Q9M1V1 View 3D Structure Click here
Q9M1V2 View 3D Structure Click here
Q9NS84 View 3D Structure Click here
Q9QUP4 View 3D Structure Click here
Q9QWG7 View 3D Structure Click here
Q9QZL2 View 3D Structure Click here
Q9QZS6 View 3D Structure Click here
Q9R1I1 View 3D Structure Click here
Q9SD25 View 3D Structure Click here
Q9STQ6 View 3D Structure Click here
Q9TZK5 View 3D Structure Click here
Q9U2Z2 View 3D Structure Click here
Q9V3L1 View 3D Structure Click here
Q9VHH0 View 3D Structure Click here
Q9VMC3 View 3D Structure Click here
Q9VMC4 View 3D Structure Click here
Q9VWJ7 View 3D Structure Click here
Q9W1L8 View 3D Structure Click here
Q9WUW8 View 3D Structure Click here
Q9WUW9 View 3D Structure Click here
Q9Y278 View 3D Structure Click here
Q9Y4C5 View 3D Structure Click here
Q9Y661 View 3D Structure Click here
Q9Y662 View 3D Structure Click here
Q9Y663 View 3D Structure Click here
Q9ZPQ5 View 3D Structure Click here