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216  structures 8200  species 0  interactions 36574  sequences 3156  architectures

Family: Acyl_transf_1 (PF00698)

Summary: Acyl transferase domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Acyl transferase domain Provide feedback

No Pfam abstract.

Literature references

  1. Serre L, Verbree EC, Dauter Z, Stuitje AR, Derewenda ZS; , J Biol Chem 1995;270:12961-12964.: The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component. PUBMED:7768883 EPMC:7768883


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR014043

Enzymes like bacterial malonyl CoA-acly carrier protein transacylase ( EC ) and eukaryotic fatty acid synthase ( EC ) that are involved in fatty acid biosynthesis belong to this group. Also included are the polyketide synthases 6-methylsalicylic acid synthase ( EC ), a multifunctional enzyme that involved in the biosynthesis of patulin and conidial green pigment synthase ( EC ) and several non-reducing polyketide synthases.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Patatin (CL0323), which has the following description:

This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes.

The clan contains the following 4 members:

Acyl_transf_1 Patatin PLA2_B SAT

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(8)
Full
(36574)
Representative proteomes UniProt
(130288)
RP15
(3507)
RP35
(14850)
RP55
(34127)
RP75
(59434)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(8)
Full
(36574)
Representative proteomes UniProt
(130288)
RP15
(3507)
RP35
(14850)
RP55
(34127)
RP75
(59434)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(8)
Full
(36574)
Representative proteomes UniProt
(130288)
RP15
(3507)
RP35
(14850)
RP55
(34127)
RP75
(59434)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_250 (release 2.1)
Previous IDs: Acyl_transf;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 8
Number in full: 36574
Average length of the domain: 298.7 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 19.45 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 32.7 32.7
Trusted cut-off 32.7 32.7
Noise cut-off 32.6 32.6
Model length: 319
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Acyl_transf_1 domain has been found. There are 216 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044TXS3 View 3D Structure Click here
A0A067XNI2 View 3D Structure Click here
A0A075TRC0 View 3D Structure Click here
A0A077Z0J0 View 3D Structure Click here
A0A077ZIJ4 View 3D Structure Click here
A0A084R1H6 View 3D Structure Click here
A0A089QRB9 View 3D Structure Click here
A0A098D6U0 View 3D Structure Click here
A0A098D8A0 View 3D Structure Click here
A0A0A0RM07 View 3D Structure Click here
A0A0A2JW91 View 3D Structure Click here
A0A0D2D9I2 View 3D Structure Click here
A0A0D2GG68 View 3D Structure Click here
A0A0D2H3J8 View 3D Structure Click here
A0A0D2YG10 View 3D Structure Click here
A0A0H3GPE4 View 3D Structure Click here
A0A0H3GR66 View 3D Structure Click here
A0A0H4ADX3 View 3D Structure Click here
A0A0J9XPA4 View 3D Structure Click here
A0A0K0ELX4 View 3D Structure Click here
A0A0K0EMZ7 View 3D Structure Click here
A0A0K0ESV2 View 3D Structure Click here
A0A0N4UH23 View 3D Structure Click here
A0A158Q536 View 3D Structure Click here
A0A175VMR7 View 3D Structure Click here
A0A175VSS8 View 3D Structure Click here
A0A175VTR7 View 3D Structure Click here
A0A175VUR4 View 3D Structure Click here
A0A175VVF0 View 3D Structure Click here
A0A175VVT3 View 3D Structure Click here
A0A175VXF2 View 3D Structure Click here
A0A175VY08 View 3D Structure Click here
A0A175VZ44 View 3D Structure Click here
A0A175VZ76 View 3D Structure Click here
A0A175VZM2 View 3D Structure Click here
A0A175W020 View 3D Structure Click here
A0A175W1V7 View 3D Structure Click here
A0A175W241 View 3D Structure Click here
A0A175W6A5 View 3D Structure Click here
A0A175W6F9 View 3D Structure Click here