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1  structure 1466  species 0  interactions 16320  sequences 265  architectures

Family: CNH (PF00780)

Summary: CNH domain

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CNH domain Provide feedback

Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001180

Based on sequence similarities a domain of homology has been identified in the following proteins [ PUBMED:10391936 ]:

  • Citron and Citron kinase. These two proteins interact with the GTP-bound forms of the small GTPases Rho and Rac but not with Cdc42.
  • Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCKalpha). This serine/threonine kinase interacts with the GTP-bound form of the small GTPase Cdc42 and to a lesser extent with that of Rac.
  • NCK Interacting Kinase (NIK), a serine/threonine protein kinase.
  • ROM-1 and ROM-2, from yeast. These proteins are GDP/GTP exchange proteins (GEPs) for the small GTP binding protein Rho1.

This domain, called the citron homology domain, is often found after cysteine rich and pleckstrin homology (PH) domains at the C-terminal end of the proteins [ PUBMED:10391936 ]. It acts as a regulatory domain and could be involved in macromolecular interactions [ PUBMED:10391936 , PUBMED:9135144 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(47)
Full
(16320)
Representative proteomes UniProt
(24172)
RP15
(1907)
RP35
(4966)
RP55
(11755)
RP75
(16522)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(47)
Full
(16320)
Representative proteomes UniProt
(24172)
RP15
(1907)
RP35
(4966)
RP55
(11755)
RP75
(16522)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(47)
Full
(16320)
Representative proteomes UniProt
(24172)
RP15
(1907)
RP35
(4966)
RP55
(11755)
RP75
(16522)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Alignment kindly provided by SMART
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: SMART
Number in seed: 47
Number in full: 16320
Average length of the domain: 264.60 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 22.79 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.0 26.0
Trusted cut-off 26.0 26.0
Noise cut-off 25.9 25.9
Model length: 254
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CNH domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JV19 View 3D Structure Click here
A0A0G2JX90 View 3D Structure Click here
A0A0G2K490 View 3D Structure Click here
A0A0G2K7W4 View 3D Structure Click here
A0A0G2KA50 View 3D Structure Click here
A0A0R0LJG6 View 3D Structure Click here
A0A0R4IDB7 View 3D Structure Click here
A0A0R4IEP9 View 3D Structure Click here
A0A0R4ITK2 View 3D Structure Click here
A0A0R4IVF8 View 3D Structure Click here
A0A1D6L259 View 3D Structure Click here
A0A1D6LIJ2 View 3D Structure Click here
A0A1D6QRU3 View 3D Structure Click here
A0A1D8PDA9 View 3D Structure Click here
A0A1D8PGN0 View 3D Structure Click here
A0A1D8PUA0 View 3D Structure Click here
A0A2R8QM71 View 3D Structure Click here
A1ZBH7 View 3D Structure Click here
A4IG72 View 3D Structure Click here
A5PF44 View 3D Structure Click here
B0G127 View 3D Structure Click here
B8A6G9 View 3D Structure Click here
D3Z837 View 3D Structure Click here
D3Z8I4 View 3D Structure Click here
D3ZHL6 View 3D Structure Click here
D3ZXB1 View 3D Structure Click here
E7F7S9 View 3D Structure Click here
E7FDE3 View 3D Structure Click here
E7FGD8 View 3D Structure Click here
E9PSL7 View 3D Structure Click here
F1LP90 View 3D Structure Click here
F1LZB6 View 3D Structure Click here
F1QN82 View 3D Structure Click here
F1QQG8 View 3D Structure Click here
F1RCV6 View 3D Structure Click here
F1RDG5 View 3D Structure Click here
F4I312 View 3D Structure Click here
I1LHS2 View 3D Structure Click here
K7L130 View 3D Structure Click here
M9PI41 View 3D Structure Click here