Summary: ER lumen protein retaining receptor
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ER lumen protein retaining receptor Provide feedback
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Internal database links
|SCOOP:||AmiS_UreI MtN3_slv PQ-loop DUF805 Chs3p UPF0542|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000133
Proteins resident in the lumen of the endoplasmic reticulum (ER) contain a C-terminal tetrapeptide, commonly known as Lys-Asp-Glu-Leu (KDEL) in mammals and His-Asp-Glu-Leu (HDEL) in yeast (Saccharomyces cerevisiae) that acts as a signal for their retrieval from subsequent compartments of the secretory pathway. The receptor for this signal is a ~26 kDa Golgi membrane protein, initially identified as the ERD2 gene product in S. cerevisiae. The receptor molecule, known variously as the ER lumen protein retaining receptor or the 'KDEL receptor', is believed to cycle between the cis side of the Golgi apparatus and the ER. It has also been characterised in a number of other species, including plants, Plasmodium, Drosophila and mammals. In mammals, 2 highly related forms of the receptor are known.
The KDEL receptor is a highly hydrophobic protein of 220 residues; its sequence exhibits 7 hydrophobic regions, all of which have been suggested to traverse the membrane [PUBMED:8392934]. More recently, however, it has been suggested that only 6 of these regions are transmembrane (TM), resulting in both N- and C-termini on the cytoplasmic side of the membrane.
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|Cellular component||integral component of membrane (GO:0016021)|
|Molecular function||ER retention sequence binding (GO:0046923)|
|Biological process||protein retention in ER lumen (GO:0006621)|
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The clan forms a large and diverse family of proteins with seven transmembrane helices, common topology and, most likely, similar function. Their coding genes exist in all eukaryota and in several prokaryota. Some are responsible for metabolic diseases (cystinosis, congenital disorder of glycosylation), others are candidate genes for genetic disorders (cleft lip and palate, certain forms of cancer) or solute uptake and efflux (SWEETs) and many have not yet been assigned a function. Comparison with the properties of well-annotated clan members suggests that the proteins could be involved in protein trafficking and serve as cargo receptors in vesicle trafficking .
The clan contains the following 5 members:ER_lumen_recept LAB_N MPC MtN3_slv PQ-loop
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Curation and family details
|Seed source:||Pfam-B_1387 (release 2.1)|
|Number in seed:||257|
|Number in full:||1423|
|Average length of the domain:||137.90 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||58.35 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||14|
|Download:||download the raw HMM for this family|
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