Summary: Borrelia lipoprotein
Borrelia lipoprotein Provide feedback
This family of lipoproteins is found in Borrelia spirochetes. The function of these proteins is uncertain.
Fraser CM, Casjens S, Huang WM, Sutton GG, Clayton R, Lathigra R, White O, Ketchum KA, Dodson R, Hickey EK, Gwinn M, Dougherty B, Tomb JF, Fleischmann RD, Richardson D, Peterson J, Kerlavage AR, Quackenbush J, Salzberg S, Hanson M, van Vugt R, Palmer N, A, Nature. 1997;390:580-586.: Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. PUBMED:9403685 EPMC:9403685
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This tab holds annotation information from the InterPro database.
InterPro entry IPR001809The ospA and ospB genes encode the major outer membrane proteins of the Lyme disease spirochaete Borrelia burgdorferi [PUBMED:2761388]. The deduced gene products OspA and OspB, contain 273 and 296 residues respectively [PUBMED:2761388]. The two Osp proteins show a high degree of sequence similarity, indicating a recent evolutionary event. Molecular analysis and sequence comparison of OspA and OspB with other proteins has revealed similarity to the signal peptides of prokaryotic lipoproteins [PUBMED:2761388, PUBMED:1560779].
|Cellular component||cell outer membrane (GO:0009279)|
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_1321 (release 2.1)|
|Number in seed:||2|
|Number in full:||624|
|Average length of the domain:||176.80 aa|
|Average identity of full alignment:||68 %|
|Average coverage of the sequence by the domain:||94.98 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Lipoprotein_1 domain has been found. There are 32 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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