Summary: POT family
This is the Wikipedia entry entitled "Proton-dependent oligopeptide transporter". More...
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Proton-dependent oligopeptide transporter Edit Wikipedia article
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The transport of peptides into cells is a well-documented biological phenomenon which is accomplished by specific, energy-dependent transporters found in a number of organisms as diverse as bacteria and humans. The proton-dependent oligopeptide transporter (PTR) family of proteins is distinct from the ABC-type peptide transporters and was uncovered by sequence analyses of a number of recently discovered peptide transport proteins. These proteins that seem to be mainly involved in the intake of small peptides with the concomitant uptake of a proton.
Human proteins containing this domain
- Naider F, Becker JM, Steiner HY (1995). "The PTR family: a new group of peptide transporters". Mol. Microbiol. 16 (5): 825–834. doi:10.1111/j.1365-2958.1995.tb02310.x. PMID 7476181.
- Skurray RA, Paulsen IT (1994). "The POT family of transport proteins". Trends Biochem. Sci. 19 (10): 404–404. doi:10.1016/0968-0004(94)90087-6. PMID 7817396.
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POT family Provide feedback
The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters .
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000109
This entry represents the POT (proton-dependent oligopeptide transport) family, which all appear to be proton dependent transporters. The transport of peptides into cells is a well-documented biological phenomenon which is accomplished by specific, energy-dependent transporters found in a number of organisms as diverse as bacteria and humans. The POT family of proteins is distinct from the ABC-type peptide transporters and was uncovered by sequence analyses of a number of recently discovered peptide transport proteins [PUBMED:7476181]. These proteins that seem to be mainly involved in the intake of small peptides with the concomitant uptake of a proton [PUBMED:7817396].
These integral membrane proteins are predicted to comprise twelve transmembrane regions.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Molecular function||transporter activity (GO:0005215)|
|Biological process||oligopeptide transport (GO:0006857)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth . It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity . All permeases of the MFS possess either 12 or 14 transmembrane helices .
The clan contains the following 25 members:Acatn ATG22 BT1 CLN3 DUF1228 DUF791 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_571 (release 3.0)|
|Number in seed:||25|
|Number in full:||7665|
|Average length of the domain:||304.30 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||67.32 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PTR2 domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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