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31  structures 338  species 0  interactions 2892  sequences 59  architectures

Family: Sucrose_synth (PF00862)

Summary: Sucrose synthase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Sucrose synthase". More...

Sucrose synthase Edit Wikipedia article

Ribbon Diagram of Sucrose Synthase-1 3S27.
Ribbon diagram of Sucrose Synthase-1 3S27 Structure, isolated from Arabidopsis thaliana.[1]
sucrose synthase
Identifiers
EC number2.4.1.13
CAS number9030-05-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Sucrose synthase
Identifiers
SymbolSucrose_synth
PfamPF00862
InterProIPR000368

In enzymology, a sucrose synthase (EC 2.4.1.13) is an enzyme that catalyzes the chemical reaction

NDP-glucose + D-fructose ⇌ NDP + sucrose

Thus, the two substrates of this enzyme are NDP-glucose and D-fructose, whereas its two products are NDP and sucrose.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase. Other names in common use include UDPglucose-fructose glucosyltransferase, sucrose synthetase, sucrose-UDP glucosyltransferase, sucrose-uridine diphosphate glucosyltransferase, and uridine diphosphoglucose-fructose glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

References

  1. ^ Zheng, Yi; Spencer, A.; Zhang, Y.; Garavito, R.M. (24 August 2011). "The Structure of Sucrose Synthase-1 from Arabidopsis thaliana and its Functional Implications". Journal of Biological Chemistry. 286: 36108–36118. doi:10.1074/jbc.M111.275974. PMC 3195635. PMID 21865170.; rendered with PyMOL

Literature


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Sucrose synthase Provide feedback

Sucrose synthases catalyse the synthesis of sucrose from UDP-glucose and fructose. This family includes the bulk of the sucrose synthase protein. However the carboxyl terminal region of the sucrose synthases belongs to the glycosyl transferase family PF00534.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000368

Sucrose synthases catalyse the synthesis of sucrose EC in the following reaction: UDP-glucose + D-fructose = UDP + sucrose This family includes the bulk of the sucrose synthase protein. However the carboxyl terminal region of the sucrose synthases belongs to the glycosyl transferase family INTERPRO . This enzyme is found mainly in plants but also appears in bacteria.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(22)
Full
(2892)
Representative proteomes UniProt
(5331)
RP15
(276)
RP35
(1332)
RP55
(2314)
RP75
(3250)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(22)
Full
(2892)
Representative proteomes UniProt
(5331)
RP15
(276)
RP35
(1332)
RP55
(2314)
RP75
(3250)
Alignment:
Format:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(22)
Full
(2892)
Representative proteomes UniProt
(5331)
RP15
(276)
RP35
(1332)
RP55
(2314)
RP75
(3250)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_484 (release 3.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 22
Number in full: 2892
Average length of the domain: 368.70 aa
Average identity of full alignment: 38 %
Average coverage of the sequence by the domain: 51.00 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 19.4 19.4
Trusted cut-off 19.5 19.4
Noise cut-off 19.3 19.2
Model length: 548
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sucrose_synth domain has been found. There are 31 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R0K711 View 3D Structure Click here
A0A1D6E268 View 3D Structure Click here
A0A1D6E340 View 3D Structure Click here
A0A1D6FIB1 View 3D Structure Click here
A0A1D6FU36 View 3D Structure Click here
A0A1D6GQ28 View 3D Structure Click here
A0A1D6H2R7 View 3D Structure Click here
A0A1D6I4J1 View 3D Structure Click here
A0A1D6IX24 View 3D Structure Click here
A0A1D6JWU6 View 3D Structure Click here
A0A1D6K2D7 View 3D Structure Click here
A0A1D6K2G3 View 3D Structure Click here
A0A1D6LG94 View 3D Structure Click here
A0A1D6LL31 View 3D Structure Click here
A0A1D6LQW1 View 3D Structure Click here
A0A1D6N358 View 3D Structure Click here
A0A1D6NT56 View 3D Structure Click here
A0A1D6P3X6 View 3D Structure Click here
A0A1D6Q051 View 3D Structure Click here
A0A1D6QA05 View 3D Structure Click here
A0A1D6QRX0 View 3D Structure Click here
B7F7B9 View 3D Structure Click here
C0P6F8 View 3D Structure Click here
F4JLK2 View 3D Structure Click here
F4K5W8 View 3D Structure Click here
H6TFZ4 View 3D Structure Click here
I1JHR7 View 3D Structure Click here
I1KFX9 View 3D Structure Click here
I1KY06 View 3D Structure Click here
I1L1U2 View 3D Structure Click here
I1L3X9 View 3D Structure Click here
I1LM80 View 3D Structure Click here
I1M6Y2 View 3D Structure Click here
I1MBQ9 View 3D Structure Click here
I1MHJ6 View 3D Structure Click here
I1MQL2 View 3D Structure Click here
I1MU40 View 3D Structure Click here
I1N0X9 View 3D Structure Click here
K7KGC7 View 3D Structure Click here
K7L1W4 View 3D Structure Click here
K7M052 View 3D Structure Click here
K7MBG3 View 3D Structure Click here
K7MJY8 View 3D Structure Click here
K7MZJ0 View 3D Structure Click here
K7TVE3 View 3D Structure Click here
P04712 View 3D Structure Click here
P13708 View 3D Structure Click here
P30298 View 3D Structure Click here
P31924 View 3D Structure Click here
P31927 View 3D Structure Click here
P49036 View 3D Structure Click here
P49040 View 3D Structure Click here
Q00917 View 3D Structure Click here
Q0JGK4 View 3D Structure Click here
Q10LP5 View 3D Structure Click here
Q43009 View 3D Structure Click here
Q67WN8 View 3D Structure Click here
Q6K973 View 3D Structure Click here
Q6ZHZ1 View 3D Structure Click here
Q7XNX6 View 3D Structure Click here
Q8RY24 View 3D Structure Click here
Q9FX32 View 3D Structure Click here
Q9FY54 View 3D Structure Click here
Q9LXL5 View 3D Structure Click here
Q9M111 View 3D Structure Click here