Summary: Sulfate transporter family
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Sulfate transporter family Provide feedback
Mutations in P50443 lead to several human diseases.
Internal database links
|Similarity to PfamA using HHSearch:||Xan_ur_permease|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011547
A number of proteins involved in the transport of sulphate across a membrane as well as some yet uncharacterised proteins have been shown [PUBMED:8140616, PUBMED:7616962] to be evolutionary related. These proteins are:
- Neurospora crassa sulphate permease II (gene cys-14).
- Yeast sulphate permeases (genes SUL1 and SUL2).
- Rat sulphate anion transporter 1 (SAT-1).
- Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
- Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
- Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
- Human protein DRA (Down-Regulated in Adenoma).
- Soybean early nodulin 70.
- Escherichia coli hypothetical protein ychM.
- Caenorhabditis elegans hypothetical protein F41D9.5.
These proteins are highly hydrophobic and seem to contain about 12 transmembrane domains.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||sulfate transmembrane transporter activity (GO:0015116)|
|Biological process||sulfate transport (GO:0008272)|
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This example describes an architecture with one
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This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.
The clan contains the following 18 members:AA_permease AA_permease_2 AA_permease_C Aa_trans BenE Branch_AA_trans CstA HCO3_cotransp K_trans Na_Ala_symp Nramp Spore_permease SSF Sulfate_tra_GLY Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_223 (release 3.0)|
|Number in seed:||34|
|Number in full:||7799|
|Average length of the domain:||253.50 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||45.21 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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