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18  structures 6565  species 0  interactions 28102  sequences 266  architectures

Family: Sulfate_transp (PF00916)

Summary: Sulfate permease family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Sulfate permease family Provide feedback

This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR011547

This entry represents a conserved domain found in a group of sulphate transporters, known as the SLC26A/SulP family [ PUBMED:8140616 , PUBMED:7616962 ]. These proteins contain an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain a STAS (sulfate transporter and anti-sigma factor antagonist) domain [ PUBMED:10662676 ]. This central domain is usually found next to the STAS domain ( INTERPRO ). Proteins containing this domain include:

  • Neurospora crassa sulphate permease II (gene cys-14).
  • Yeast sulphate permeases (genes SUL1 and SUL2).
  • Rat sulphate anion transporter 1 (SAT-1).
  • Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
  • Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
  • Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
  • Human protein DRA (Down-Regulated in Adenoma).
  • Soybean early nodulin 70.
  • Escherichia coli hypothetical protein ychM.
  • Caenorhabditis elegans hypothetical protein F41D9.5.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan APC (CL0062), which has the following description:

This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.

The clan contains the following 20 members:

AA_permease AA_permease_2 AA_permease_C Aa_trans BCCT BenE Branch_AA_trans CstA HCO3_cotransp K_trans MFS_MOT1 Na_Ala_symp Nramp SNF Spore_permease SSF Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(22)
Full
(28102)
Representative proteomes UniProt
(96614)
RP15
(3842)
RP35
(12637)
RP55
(26069)
RP75
(42069)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(22)
Full
(28102)
Representative proteomes UniProt
(96614)
RP15
(3842)
RP35
(12637)
RP55
(26069)
RP75
(42069)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(22)
Full
(28102)
Representative proteomes UniProt
(96614)
RP15
(3842)
RP35
(12637)
RP55
(26069)
RP75
(42069)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_223 (release 3.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 22
Number in full: 28102
Average length of the domain: 314.20 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 58.03 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.2 23.2
Trusted cut-off 23.2 23.2
Noise cut-off 23.1 23.1
Model length: 380
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sulfate_transp domain has been found. There are 18 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0VTN1 View 3D Structure Click here
A0A0P0X547 View 3D Structure Click here
A0A0R0F0Y9 View 3D Structure Click here
A0A0R0FAY8 View 3D Structure Click here
A0A0R0FWM1 View 3D Structure Click here
A0A0R0HV67 View 3D Structure Click here
A0A0R0K6T6 View 3D Structure Click here
A0A0R0K6T6 View 3D Structure Click here
A0A0R0KMV7 View 3D Structure Click here
A0A0R0LEC1 View 3D Structure Click here
A0A0R4IDN4 View 3D Structure Click here
A0A1D6ELE0 View 3D Structure Click here
A0A1D6JSH0 View 3D Structure Click here
A0A1D6NDM4 View 3D Structure Click here
A0A1D6PID5 View 3D Structure Click here
A0A1D6Q0R8 View 3D Structure Click here
A0A1D8PLL2 View 3D Structure Click here
A0A1D8PRZ2 View 3D Structure Click here
A0A1W2Q610 View 3D Structure Click here
A0A1X7YGK6 View 3D Structure Click here
A0A2R8QAU0 View 3D Structure Click here
A0A368UI22 View 3D Structure Click here
A0A368UI22 View 3D Structure Click here
A0A368UKL4 View 3D Structure Click here
A0A368UKL4 View 3D Structure Click here
A4I3P7 View 3D Structure Click here
A7YF68 View 3D Structure Click here
A9C3T3 View 3D Structure Click here
B0G157 View 3D Structure Click here
B0V3V8 View 3D Structure Click here
B6DUH7 View 3D Structure Click here
B6DUH8 View 3D Structure Click here
C0P5B8 View 3D Structure Click here
C0PH01 View 3D Structure Click here
D3Z9I5 View 3D Structure Click here
D3ZV32 View 3D Structure Click here
D3ZXL0 View 3D Structure Click here
E7F9I7 View 3D Structure Click here
E7FF67 View 3D Structure Click here
F1M067 View 3D Structure Click here
F1QGE0 View 3D Structure Click here
F7F9X9 View 3D Structure Click here
G5EC30 View 3D Structure Click here
G5EDS5 View 3D Structure Click here
G5EEA7 View 3D Structure Click here
G5EED0 View 3D Structure Click here
G5EFB2 View 3D Structure Click here
I1JDS8 View 3D Structure Click here
I1JNX0 View 3D Structure Click here
I1KA20 View 3D Structure Click here
I1KA21 View 3D Structure Click here
I1KG82 View 3D Structure Click here
I1KM59 View 3D Structure Click here
I1KM60 View 3D Structure Click here
I1KT54 View 3D Structure Click here
I1KUE7 View 3D Structure Click here
I1KV89 View 3D Structure Click here
I1L867 View 3D Structure Click here
I1LN03 View 3D Structure Click here
I1LW07 View 3D Structure Click here
I1M5M2 View 3D Structure Click here
I1MAQ9 View 3D Structure Click here
I1MCM8 View 3D Structure Click here
I1MYU2 View 3D Structure Click here
I1MYU4 View 3D Structure Click here
I1N522 View 3D Structure Click here
I1N9K0 View 3D Structure Click here
I1ND92 View 3D Structure Click here
K7K8D7 View 3D Structure Click here
K7KCF2 View 3D Structure Click here
K7L784 View 3D Structure Click here
K7LX04 View 3D Structure Click here
K7M7J3 View 3D Structure Click here
K7N1L7 View 3D Structure Click here
K7W282 View 3D Structure Click here
O04289 View 3D Structure Click here
O04722 View 3D Structure Click here
O17951 View 3D Structure Click here
O33206 View 3D Structure Click here
O33206 View 3D Structure Click here
O43511 View 3D Structure Click here
O45016 View 3D Structure Click here
O59782 View 3D Structure Click here
O70531 View 3D Structure Click here
O74377 View 3D Structure Click here
P0AFR2 View 3D Structure Click here
P38359 View 3D Structure Click here
P40879 View 3D Structure Click here
P45380 View 3D Structure Click here
P50443 View 3D Structure Click here
P53273 View 3D Structure Click here
P53394 View 3D Structure Click here
P58735 View 3D Structure Click here
P58743 View 3D Structure Click here
P92946 View 3D Structure Click here
P96878 View 3D Structure Click here
P9WGF7 View 3D Structure Click here
Q02920 View 3D Structure Click here
Q09764 View 3D Structure Click here
Q0IXM8 View 3D Structure Click here
Q0J5T2 View 3D Structure Click here
Q0J9H5 View 3D Structure Click here
Q10QI2 View 3D Structure Click here
Q10QI4 View 3D Structure Click here
Q12325 View 3D Structure Click here
Q1RLN9 View 3D Structure Click here
Q4DK74 View 3D Structure Click here
Q4DSC3 View 3D Structure Click here
Q551C0 View 3D Structure Click here
Q55FJ8 View 3D Structure Click here
Q55FK8 View 3D Structure Click here
Q59RH2 View 3D Structure Click here
Q5EBI0 View 3D Structure Click here
Q5VQ79 View 3D Structure Click here
Q62273 View 3D Structure Click here
Q68UR2 View 3D Structure Click here
Q7K155 View 3D Structure Click here
Q7K4I4 View 3D Structure Click here
Q7LBE3 View 3D Structure Click here
Q7T2C4 View 3D Structure Click here
Q80ZD3 View 3D Structure Click here
Q86WA9 View 3D Structure Click here
Q8BU91 View 3D Structure Click here
Q8CIW6 View 3D Structure Click here
Q8GYH8 View 3D Structure Click here
Q8H7X3 View 3D Structure Click here
Q8H7X4 View 3D Structure Click here
Q8IKC7 View 3D Structure Click here
Q8LR58 View 3D Structure Click here
Q8NG04 View 3D Structure Click here
Q8R0C3 View 3D Structure Click here
Q8R2Z3 View 3D Structure Click here
Q8TE54 View 3D Structure Click here
Q924C9 View 3D Structure Click here
Q94225 View 3D Structure Click here
Q942E2 View 3D Structure Click here
Q94LW6 View 3D Structure Click here
Q96RN1 View 3D Structure Click here
Q99NH7 View 3D Structure Click here
Q9BXS9 View 3D Structure Click here
Q9EPH0 View 3D Structure Click here
Q9FEP7 View 3D Structure Click here
Q9FY46 View 3D Structure Click here
Q9H2B4 View 3D Structure Click here
Q9I7H4 View 3D Structure Click here
Q9LW86 View 3D Structure Click here
Q9MAX3 View 3D Structure Click here
Q9R154 View 3D Structure Click here
Q9R155 View 3D Structure Click here
Q9SAY1 View 3D Structure Click here
Q9SV13 View 3D Structure Click here
Q9SXS2 View 3D Structure Click here
Q9URY8 View 3D Structure Click here
Q9VA55 View 3D Structure Click here
Q9VAC2 View 3D Structure Click here
Q9VC29 View 3D Structure Click here
Q9VF45 View 3D Structure Click here
Q9VF65 View 3D Structure Click here
Q9VVM6 View 3D Structure Click here
Q9WVC8 View 3D Structure Click here