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283  structures 1055  species 12  interactions 2716  sequences 69  architectures

Family: DPPIV_N (PF00930)

Summary: Dipeptidyl peptidase IV (DPP IV) N-terminal region

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Dipeptidyl-peptidase IV family". More...

Dipeptidyl-peptidase IV family Edit Wikipedia article

Dipeptidyl peptidase IV (DPP IV) N-terminal region
PDB 2ajc EBI.jpg
porcine dipeptidyl peptidase iv (cd26) in complex with 4-(2-aminoethyl)-benzene sulphonyl fluoride (aebsf)
Identifiers
Symbol DPPIV_N
Pfam PF00930
Pfam clan CL0186
InterPro IPR002469
PROSITE PDOC00587
MEROPS S9
SCOP 1n1m
SUPERFAMILY 1n1m

In molecular biology, the dipeptidyl-peptidase IV family is a family of serine peptidases which belong to MEROPS peptidase family S9 (clan SC), subfamily S9B (dipeptidyl-peptidase IV). The protein fold of the peptidase domain for members of this family resembles that of serine carboxypeptidase D, the type example of clan SC. The type example of this family is Dipeptidyl peptidase-4.[1]

Human proteins in this family are:

External links

References

  1. ^ Misumi, Y.; Hayashi, Y.; Arakawa, F.; Ikehara, Y. (1992). "Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface". Biochimica et Biophysica Acta 1131 (3): 333–336. doi:10.1016/0167-4781(92)90036-y. PMID 1352704. 

This article incorporates text from the public domain Pfam and InterPro IPR002469

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Dipeptidyl peptidase IV (DPP IV) N-terminal region Provide feedback

This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002469

This domain defines serine peptidases belonging to MEROPS peptidase family S9 (clan SC), subfamily S9B (dipeptidyl-peptidase IV). The protein fold of the peptidase domain for members of this family resembles that of serine carboxypeptidase D, the type example of clan SC. This domain is an alignment of the region to the N-terminal side of the active site, which is found in INTERPRO.

Dipeptidyl-peptidase IV (EC) is also called adenosine deaminase-binding protein (ADA-binding protein) or CD26. The exopeptidase cleaves off N-terminal X-Pro or X-Ala dipeptides from polypeptides (dipeptidyl peptidase IV activity). It serves as the costimulatory molecule in T cell activation and is an associated marker of autoimmune diseases, adenosine deaminase-deficiency and HIV pathogenesis [PUBMED:1352530, PUBMED:20959412, PUBMED:21856036].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Beta_propeller (CL0186), which has the following description:

This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled. The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.

The clan contains the following 71 members:

ANAPC4_WD40 Arylesterase Arylsulfotran_2 Arylsulfotrans BBS2_Mid Beta_propel Coatomer_WDAD CPSF_A Cytochrom_D1 DPPIV_N DUF1513 DUF1668 DUF2415 DUF4221 DUF4934 DUF5046 DUF5050 DUF5122 DUF5128 DUF839 eIF2A FG-GAP FG-GAP_2 Frtz Ge1_WD40 Glu_cyclase_2 Gmad1 GSDH IKI3 Itfg2 Kelch_1 Kelch_2 Kelch_3 Kelch_4 Kelch_5 Kelch_6 Lactonase Ldl_recept_b Lgl_C LVIVD Me-amine-dh_H MRJP Nbas_N Neisseria_PilC NHL Nucleoporin_N Nup160 PALB2_WD40 PD40 Pectate_lyase22 Peptidase_S9_N Phytase-like PQQ PQQ_2 PQQ_3 RAG2 RCC1 RCC1_2 Reg_prop SBBP SBP56 SdiA-regulated SGL Str_synth TcdB_toxin_midN TolB_like VCBS WD40 WD40_3 WD40_4 WD40_like

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(35)
Full
(2716)
Representative proteomes UniProt
(7252)
NCBI
(13983)
Meta
(887)
RP15
(626)
RP35
(1554)
RP55
(2777)
RP75
(4005)
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PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(35)
Full
(2716)
Representative proteomes UniProt
(7252)
NCBI
(13983)
Meta
(887)
RP15
(626)
RP35
(1554)
RP55
(2777)
RP75
(4005)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(35)
Full
(2716)
Representative proteomes UniProt
(7252)
NCBI
(13983)
Meta
(887)
RP15
(626)
RP35
(1554)
RP55
(2777)
RP75
(4005)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1017 (release 3.0)
Previous IDs: DPPIV_N_term;
Type: Family
Author: Finn RD, Bateman A
Number in seed: 35
Number in full: 2716
Average length of the domain: 315.00 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 42.57 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.2 20.2
Trusted cut-off 20.2 20.2
Noise cut-off 20.1 20.1
Model length: 354
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Interactions

There are 12 interactions for this family. More...

TolB_N Peptidase_S9 A_deaminase Cloacin PD40 TolB_N Spike_rec_bind DPPIV_N OmpA Peptidase_S9 Hormone_3 PD40

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DPPIV_N domain has been found. There are 283 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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