# STOCKHOLM 1.0 #=GF ID Flavi_NS2B #=GF AC PF01002.22 #=GF DE Flavivirus non-structural protein NS2B #=GF AU Finn RD;0000-0001-8626-2148 #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE Pfam-B_156 (release 3.0) #=GF GA 23.50 23.50; #=GF TC 23.80 100.40; #=GF NC 23.30 19.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 9499070 #=GF RT Signal peptidase cleavage at the flavivirus C-prM junction: #=GF RT dependence on the viral NS2B-3 protease for efficient processing #=GF RT requires determinants in C, the signal peptide, and prM. #=GF RA Stocks CE, Lobigs M; #=GF RL J Virol 1998;72:2141-2149. #=GF RN [2] #=GF RM 7884844 #=GF RT Formation of the flavivirus envelope: role of the viral NS2B-NS3 #=GF RT protease. #=GF RA Yamshchikov VF, Compans RW; #=GF RL J Virol 1995;69:1995-2003. #=GF DR INTERPRO; IPR000487; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC Flaviviruses encode a single polyprotein. This is cleaved into #=GF CC three structural and seven non-structural proteins. All, but #=GF CC two, are cleaved by the NS2B-NS3 protease complex. #=GF SQ 4 #=GS POLG_YEFV1/1358-1484 AC P03314.1 #=GS POLG_ZIKV/1373-1498 AC Q32ZE1.1 #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS D; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ E; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI E; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB G; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD E; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 A; 49-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW C; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z G; 50-89; #=GS POLG_ZIKV/1373-1498 DR PDB; 6KK5 A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB E; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ C; 51-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5T1V A; 6-22; #=GS POLG_ZIKV/1373-1498 DR PDB; 6KK3 A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6Y3B A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS J; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB A; 50-88; #=GS POLG_ZIKV/1373-1498 DR PDB; 5TFN B; 49-66; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 G; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW E; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6KK6 A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5TFN A; 50-69; #=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD C; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 E; 51-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5YOF A; 50-88; #=GS POLG_ZIKV/1373-1498 DR PDB; 5TFO A; 50-68; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 C; 49-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5TFO B; 49-64; #=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GXJ A; 50-68; #=GS POLG_ZIKV/1373-1498 DR PDB; 6KPQ A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI C; 51-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB C; 50-88; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 A; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS G; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ G; 50-88; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 G; 49-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI G; 50-89; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GXJ B; 48-68; #=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 E; 49-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW G; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5T1V B; 6-26; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z E; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD G; 50-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6KK4 A; 49-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z C; 51-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 C; 51-87; #=GS POLG_ZIKV/1373-1498 DR PDB; 6KK2 A; 50-87; #=GS POLG_DEN1W/1349-1475 AC P17763.2 #=GS A0A2V1MW33_9LACO/167-293 AC A0A2V1MW33.1 POLG_YEFV1/1358-1484 .VNEALAAAGLVGVLAGLAFQEMENFLGPIAVGGLLMMLVSVAGRVDGLELKKLGEVSWEEEAEISGSSARYDVALSEQGEFKLLSEEKVPWDQVVMTSLALVGAALHPFALLLVLAGWLFHVRGARR POLG_ZIKV/1373-1498 s--EVLTAVGLICALAGGFAKADIEMAGPMAAVGLLIVSYVVSGKSVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVEEDGPPMREIILKVVLMAICGMNPIAIPFAAGAWYVYVKTGKR #=GR POLG_ZIKV/1373-1498 SS X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEEEEEEEE----TTSEEESB--EEEEEE-TTS-EEE-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX POLG_DEN1W/1349-1475 .LNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAISGVYPMSIPATLFVWYFWQKKKQR A0A2V1MW33_9LACO/167-293 .LNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVRWEEQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR #=GC SS_cons X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEEEEEEEE----TTSEEESB--EEEEEE-TTS-EEE-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX #=GC seq_cons .lNEulhAVGlVulLAuuhhKsDlshsGPlsAGGLLhssYVloG+SsDLpLE+Au-VoWEE-AElSGuSsplsVslsEsGshplhsEEcsshhpIll+ssLLsIuGlaPhuIPhshuuWYha.+ptpR //