Summary: Hint module
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Hint module Provide feedback
This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.
Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ; , Cell 1997;91:85-97.: Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. PUBMED:9335337 EPMC:9335337
Internal database links
|Similarity to PfamA using HHSearch:||PT-HINT Hint_2 Vint|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001767
Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [PUBMED:9489693].This entry represents the hint domain.
|Molecular function||peptidase activity (GO:0008233)|
|Biological process||proteolysis (GO:0006508)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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This superfamily includes Hedgehog C-terminal (Hog) autoprocessing domain and Intein (protein splicing domain) families.
The clan contains the following 7 members:Hint Hint_2 Hom_end_hint Intein_splicing PT-HINT U6-snRNA_bdg Vint
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_766 (release 3.0)|
|Author:||Finn RD, Bateman A|
|Number in seed:||46|
|Number in full:||484|
|Average length of the domain:||193.60 aa|
|Average identity of full alignment:||31 %|
|Average coverage of the sequence by the domain:||44.69 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Hint domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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