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12  structures 66  species 3  interactions 355  sequences 3  architectures

Family: Uteroglobin (PF01099)

Summary: Uteroglobin family

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Uteroglobin family Provide feedback

Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated [1].

Literature references

  1. Dunkel R, Vriend G, Beato M, Suske G; , Protein Eng 1995;8:71-79.: Progesterone binding to uteroglobin: two alternative orientations of the ligand. PUBMED:7770456 EPMC:7770456

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR016126

Uteroglobin (or blastokinin) is a mammalian steroid-inducible secreted protein originally isolated from the uterus of rabbits during early pregnancy. The mucosal epithelia of several organs that communicate with the external environment express uteroglobin. Its tissue-specific expression is regulated by steroid hormones, and is augmented in the uterus by non-steroidal prolactin. Uteroglobin may be a multi-functional protein with anti-inflammatory/immunomodulatory properties, acting to inhibit phospholipase A2 activity, and binding to (and possibly sequestering) several hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids and prostaglandins. In addition, uteroglobin has anti-chemotactic, anti-allergic, anti-tumourigenic and embryo growth-stimulatory properties. Uteroglobin may have a homeostatic role against oxidative damage, inflammation, autoimmunity and cancer [PUBMED:17916741, PUBMED:17928103, PUBMED:11193760, PUBMED:7770456]. Uteroglobin consists of a disulphide-linked dimer of two identical polypeptides, each polypeptide being composed of four helices. It is a member of the secretoglobin superfamily.

Members of this family include:

  • Uteroglobin, a mammalian, steroid-inducible, secreted anti-inflammatory/immunomodulatory protein [PUBMED:17916741].
  • Mammaglobin, expressed in ovarian cancer cells [PUBMED:18021217].
  • Lipophilin B, which exists as a complex with mammary-specific mammaglobin A [PUBMED:17163411].
  • Clara cell 17 kDa protein, which inhibits phospholipase A2 and papain, and also binds to progesterone [PUBMED:1560460].
  • Allergen Fel d 1 (Felis silvestris catus (Cat) allergen 1) chains 1 and 2, a tetrameric glycoprotein formed by two heterodimers that elicit IgE responses in people with allergy to cats [PUBMED:17543334].

Secretoglobin proteins have a four-helical structure, and in the case of uteroglobin, form homodimers, whereas allergen Fel d 1 forms a tetramer of two heterodimers (chains 1 and 2).

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Uteroglobin (CL0370), which has the following description:

Members of this superfamily are disulfide-linked dimers of two identical chains, with 4 helices in each. They constitute important new cat, rat and rabbit allergens that are contributing to asthma world-wide.

The clan contains the following 2 members:

Feld-I_B Uteroglobin


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: Uterglobin;
Type: Domain
Author: Finn RD, Bateman A
Number in seed: 98
Number in full: 355
Average length of the domain: 65.10 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 70.32 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.8 24.8
Trusted cut-off 24.9 25.0
Noise cut-off 24.7 24.5
Model length: 67
Family (HMM) version: 13
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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There are 3 interactions for this family. More...

Uteroglobin Feld-I_B Feld-I_B


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Uteroglobin domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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