Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
9  structures 497  species 1  interaction 793  sequences 28  architectures

Family: ER (PF01133)

Summary: Enhancer of rudimentary

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "ERH (gene)". More...

ERH (gene) Edit Wikipedia article

ERH
Protein ERH PDB 1w9g.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERH, DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor
External IDsOMIM: 601191 MGI: 108089 HomoloGene: 3274 GeneCards: ERH
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for ERH
Genomic location for ERH
Band14q24.1Start69,380,128 bp[1]
End69,398,299 bp[1]
RNA expression pattern
PBB GE ERH 200043 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004450

NM_007951
NM_001347409

RefSeq (protein)

NP_004441

NP_001334338
NP_031977

Location (UCSC)Chr 14: 69.38 – 69.4 MbChr 12: 80.63 – 80.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Enhancer of rudimentary
PDB 1wz7 EBI.jpg
crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
SymbolER
PfamPF01133
InterProIPR000781
PROSITEPDOC00732
SCOPe1j24 / SUPFAM
TCDB3.A.16

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[5][6][7]

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[8]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[6] It has been proposed that this protein plays a role in the cell cycle.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100632 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021131 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics. 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID 8786099.
  6. ^ a b Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene. 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID 9074495.
  7. ^ "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)".
  8. ^ Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics. 138 (4): 1163–1170. PMC 1206255. PMID 7896098.

Further reading


External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH)
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Enhancer of rudimentary homolog (ERH)


This article incorporates text from the public domain Pfam and InterPro: IPR000781


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Enhancer of rudimentary Provide feedback

Enhancer of rudimentary is a protein of unknown function that is highly conserved in plants and animals. This protein is found to be an enhancer of the rudimentary gene P05990.

Literature references

  1. Wojcik E, Murphy AM, Fares H, Dang-Vu K, Tsubota SI; , Genetics 1994;138:1163-1170.: Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene. PUBMED:7896098 EPMC:7896098

  2. Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI; , Gene 1997;186:189-195.: The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. PUBMED:9074495 EPMC:9074495


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000781

The Drosophila protein 'enhancer of rudimentary' (gene (e(r)) is a small protein of 104 residues whose function is not yet clear. From an evolutionary point of view, it is highly conserved [PUBMED:9074495] and has been found to exist in probably all multicellular eukaryotic organisms. ERH has been implicated in the regulation of pyrimidine biosynthesis, DNA replication, transcription, mRNA splicing, cellular proliferation, tumorigenesis, and the Notch signaling pathway [PUBMED:27830090]. Fission yeast homologue of ERH is implicated in meiotic mRNA elimination during vegetative growth. It forms a stoichiometric complex with Mmi1 to promote meiotic mRNA decay and facultative heterochromatin assembly [PUBMED:26942678, PUBMED:29424342].

ERH has been shown to interact with SAFB1/SAFB2 (scaffold attachment factor-B 1/2)at the nuclear matrix to regulate SR protein phosphorylation [PUBMED:28627136].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(40)
Full
(793)
Representative proteomes UniProt
(1315)
NCBI
(1050)
Meta
(0)
RP15
(124)
RP35
(291)
RP55
(519)
RP75
(701)
Jalview View  View  View  View  View  View  View  View   
HTML View  View               
PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(40)
Full
(793)
Representative proteomes UniProt
(1315)
NCBI
(1050)
Meta
(0)
RP15
(124)
RP35
(291)
RP55
(519)
RP75
(701)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(40)
Full
(793)
Representative proteomes UniProt
(1315)
NCBI
(1050)
Meta
(0)
RP15
(124)
RP35
(291)
RP55
(519)
RP75
(701)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 40
Number in full: 793
Average length of the domain: 92.30 aa
Average identity of full alignment: 53 %
Average coverage of the sequence by the domain: 64.94 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.3 25.3
Noise cut-off 24.3 22.9
Model length: 98
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Interactions

There is 1 interaction for this family. More...

ER

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ER domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...