Summary: Ergosterol biosynthesis ERG4/ERG24 family
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Ergosterol biosynthesis ERG4/ERG24 family Provide feedback
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Internal database links
|Similarity to PfamA using HHSearch:||DUF1295|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001171
The two fungal enzymes, C-14 sterol reductase (gene ERG24 in budding yeast and erg3 in Neurospora crassa) and C-24(28) sterol reductase (gene ERG4 in budding yeast and sts1 in fission yeast), are involved in ergosterol biosynthesis. They act by reducing double bonds in precursors of ergosterol [PUBMED:8125337]. These proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions. Chicken lamin B receptor that is thought to anchor the lamina to the inner nuclear membrane belongs to this family.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
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This clan includes several enzymes, including steroid dehydrogenases and isoprenylcysteine carboxyl methyltransferase enzymes. These protein contain a varying number of transmembrane regions.
The clan contains the following 6 members:DUF1295 ERG4_ERG24 ICMT NnrU PEMT Steroid_dh
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Curation and family details
|Author:||Finn RD, Bateman A|
|Number in seed:||5|
|Number in full:||987|
|Average length of the domain:||356.30 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||87.33 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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