Summary: Membrane-associating domain
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Membrane-associating domain Provide feedback
MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins . It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR021128
This entry represents the ~130-residue MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain. The MARVEL domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. All described MARVEL domain-containing proteins are consistent with the M-shaped topology: four transmembrane-helix region architecture with cytoplasmic N- and C-terminal regions. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation [PUBMED:12468223].
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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The MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families.
The clan contains the following 3 members:DUF588 MARVEL TMEM190
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
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Curation and family details
|Author:||Finn RD, Bateman A, Yeats C|
|Number in seed:||93|
|Number in full:||2286|
|Average length of the domain:||146.20 aa|
|Average identity of full alignment:||17 %|
|Average coverage of the sequence by the domain:||64.66 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||18|
|Download:||download the raw HMM for this family|
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