Summary: Bacterial export proteins, family 1
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Bacterial export proteins, family 1 Provide feedback
This family includes the following members; FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal peptides, through the membrane. Although the proteins that these exporters move may be different, the exporters are thought to function in similar ways .
Zhuang WY, Shapiro L; , J Bacteriol 1995;177:343-356.: Caulobacter FliQ and FliR membrane proteins, required for flagellar biogenesis and cell division, belong to a family of virulence factor export proteins. PUBMED:7814323 EPMC:7814323
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This tab holds annotation information from the InterPro database.
InterPro entry IPR002010
Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [PUBMED:8969244]. There have been four secretion systems described in animal enteropathogens such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ralstonia and Erwinia [PUBMED:8969244].
The type III secretion system is of great interest, as it is used to transport virulence factors from the pathogen directly into the host cell [PUBMED:10334981] and is only triggered when the bacterium comes into close contact with the host. The protein subunits of the system are very similar to those of bacterial flagellar biosynthesis [PUBMED:10564516]. However, while the latter forms a ring structure to allow secretion of flagellin and is an integral part of the flagellum itself [PUBMED:10564516], type III subunits in the outer membrane translocate secreted proteins through a channel-like structure.
It is believed that the family of type III inner membrane proteins are used as structural moieties in a complex with several other subunits [PUBMED:9618447]. One such set of inner membrane proteins, labeled "R" here for nomenclature purposes, includes the Salmonella and Shigella SpaR, the Yersinia YscT, Rhizobium Y4YN, and the Erwinia HrcT genes [PUBMED:9618447]. The flagellar protein FliR also shares similarity, probably due to evolution of the type III secretion system from the flagellar biosynthetic pathway.
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|Cellular component||membrane (GO:0016020)|
|Biological process||protein targeting (GO:0006605)|
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Curation and family details
|Seed source:||Pfam-B_1442 (release 3.0)|
|Author:||Finn RD, Bateman A|
|Number in seed:||16|
|Number in full:||3358|
|Average length of the domain:||239.20 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||92.63 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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