# STOCKHOLM 1.0 #=GF ID ArfGap #=GF AC PF01412.19 #=GF DE Putative GTPase activating protein for Arf #=GF AU Ponting CP;0000-0003-0202-7816 #=GF AU Schultz J; #=GF AU Bork P;0000-0002-2627-833X #=GF SE SMART #=GF GA 28.70 28.70; #=GF TC 28.70 28.80; #=GF NC 28.60 28.60; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cut_ga HMM metaseq #=GF TP Domain #=GF RN [1] #=GF RM 8702546 #=GF RT Identification and cloning of centaurin-alpha. A novel #=GF RT phosphatidylinositol 3,4,5-trisphosphate-binding protein from #=GF RT rat brain. #=GF RA Hammonds-Odie LP, Jackson TR, Profit AA, Blader IJ, Turck CW, #=GF RA Prestwich GD, Theibert AB; #=GF RL J Biol Chem 1996;271:18859-18868. #=GF RN [2] #=GF RM 9151987 #=GF RT A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc #=GF RT finger motif similar to that of the ADP-ribosylation -factor #=GF RT GTPase-activating protein and two pleckstrin homology domains. #=GF RA Tanaka K, Imajoh-Ohmi S, Sawada T, Shirai R, Hashimoto Y, #=GF RA Iwasaki S, Kaibuchi K, Kanaho Y, Shirai T, Terada Y, Kimura K, #=GF RA Nagata S, Fukui Y; #=GF RL Eur J Biochem 1997;245:512-519. #=GF RN [3] #=GF RM 9446556 #=GF RT Molecular characterization of the GTPase-activating domain of #=GF RT ADP-ribosylation factor domain protein 1 (ARD1). #=GF RA Vitale N, Moss J, Vaughan M; #=GF RL J Biol Chem 1998;273:2553-2560. #=GF DR INTERPRO; IPR001164; #=GF DR SMART; ArfGAP; #=GF DR SCOP; 1dcq; fa; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC Putative zinc fingers with GTPase activating proteins (GAPs) #=GF CC towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase #=GF CC hydrolysis for ARD1 but not ARFs. #=GF SQ 33 #=GS EDG71386.1/48-158 DE [subseq from] hypothetical protein GOS_734100 [marine metagenome] #=GS ECH12863.1/13-101 DE [subseq from] hypothetical protein GOS_3030292 [marine metagenome] #=GS ECO73252.1/117-230 DE [subseq from] hypothetical protein GOS_4274262 [marine metagenome] #=GS ECZ11931.1/13-130 DE [subseq from] hypothetical protein GOS_2238516 [marine metagenome] #=GS ECY45827.1/32-141 DE [subseq from] hypothetical protein GOS_2356797 [marine metagenome] #=GS ECC54216.1/73-160 DE [subseq from] hypothetical protein GOS_3504078 [marine metagenome] #=GS ECH03953.1/8-112 DE [subseq from] hypothetical protein GOS_3370299 [marine metagenome] #=GS ECA20874.1/12-98 DE [subseq from] hypothetical protein GOS_5775004 [marine metagenome] #=GS EBF92688.1/11-98 DE [subseq from] hypothetical protein GOS_9517899 [marine metagenome] #=GS ECE46318.1/124-264 DE [subseq from] hypothetical protein GOS_6370377 [marine metagenome] #=GS ECL57426.1/143-223 DE [subseq from] hypothetical protein GOS_6356811 [marine metagenome] #=GS ECC70659.1/52-118 DE [subseq from] hypothetical protein GOS_6348754 [marine metagenome] #=GS ECI92226.1/45-156 DE [subseq from] hypothetical protein GOS_6380067 [marine metagenome] #=GS EBL27071.1/25-138 DE [subseq from] hypothetical protein GOS_8598352 [marine metagenome] #=GS EBS34338.1/54-127 DE [subseq from] hypothetical protein GOS_7452375 [marine metagenome] #=GS ECI93303.1/4-79 DE [subseq from] hypothetical protein GOS_6341922 [marine metagenome] #=GS ECJ07074.1/26-127 DE [subseq from] hypothetical protein GOS_5778213 [marine metagenome] #=GS EDH19330.1/1-86 DE [subseq from] hypothetical protein GOS_649628 [marine metagenome] #=GS ECU44880.1/19-130 DE [subseq from] hypothetical protein GOS_4323498 [marine metagenome] #=GS ECI79451.1/185-267 DE [subseq from] hypothetical protein GOS_3387018 [marine metagenome] #=GS ECN50331.1/59-90 DE [subseq from] hypothetical protein GOS_5665383 [marine metagenome] #=GS ECN50331.1/111-184 DE [subseq from] hypothetical protein GOS_5665383 [marine metagenome] #=GS ECI55684.1/18-87 DE [subseq from] hypothetical protein GOS_4324863 [marine metagenome] #=GS ECE13052.1/4-27 DE [subseq from] hypothetical protein GOS_4178305 [marine metagenome] #=GS ECE13052.1/46-125 DE [subseq from] hypothetical protein GOS_4178305 [marine metagenome] #=GS ECR66621.1/114-197 DE [subseq from] hypothetical protein GOS_4270697 [marine metagenome] #=GS ECL69795.1/23-75 DE [subseq from] hypothetical protein GOS_5855815 [marine metagenome] #=GS ECK77775.1/36-152 DE [subseq from] hypothetical protein GOS_6020125 [marine metagenome] #=GS ECS02714.1/40-113 DE [subseq from] hypothetical protein GOS_6339990 [marine metagenome] #=GS EBB29202.1/6-96 DE [subseq from] hypothetical protein GOS_258124 [marine metagenome] #=GS EBE24112.1/1-55 DE [subseq from] hypothetical protein GOS_9796682 [marine metagenome] #=GS ECQ78338.1/6-95 DE [subseq from] hypothetical protein GOS_4288466 [marine metagenome] #=GS ECT86020.1/1-70 DE [subseq from] hypothetical protein GOS_4288225 [marine metagenome] EDG71386.1/48-158 ---AQIVRA.DDDNRRCCDC...GKRNP..RWASTNLGCFMCLECSG..IHRAIGVHITKIKSITLDK..WTRSEVDHMK.KVGNRIHNAR.WEAFL..........................DNGRGI............LPQSSMRERDVFIRAKYNGRKYF--- ECH12863.1/13-101 --RLNACLK.RPENILCVDC...PMRLP..RWASLNLGVFMCTNCSG..IHRGLGVHISRVRSTQLDK..WTEDQVAFME.KMGNERANAY.WEKNI..........................PPGAKP............-------------------------- ECO73252.1/117-230 --RIEALLQ.ELGNDTCADC...LAPQP..TWASINNGVFLCTQCAG..VHRSLGVHISMVLSCKLDN..FTESQIDALE.KMGNLRSNDG.LEYHC..........................PSRWPK...........pHPEESRRYRTIYIRAKYEAKLFVR-- ECZ11931.1/13-130 ---LAEIRR.APGNSQCADC...GMADP..DWASLNLGIVVCIQCSG..VHRQLGVHVSKVRSCVLDVraWEPSVVSFFT.RWGNERHNRV.FEGAA..........................CDADGLat........kpRPNDGLDAKAAYVKAKYVAKAFFD-- ECY45827.1/32-141 --RFRILMG.KRDNKTCFDC...GAKNP..KWATVTYGVFICLGCSA..HHRRMGVHVTFVRSCDMDK..WKPSELSLMK.NGGNKRAREF.FREHG..........................WSEQRS............SLDLVQKKYQSTAAKLYRSKL----- ECC54216.1/73-160 ---QREIRE.LPGNKTCVDC...KTRNP..QWASVSYGTLMCLECSG..KHRSLGVHLSFVRSIQMDS..WTEKQIKVMR.IGGNKKFQEF.LKEKN..........................VDNSMD............-------------------------- ECH03953.1/8-112 ---IARLNA.LAKNQTCADC...ATRNP..QWASVNHGAFLCMNCSG..VHRGLGVHVSFVRSTTMDT..WSSAQLRLME.VGGNERLVKF.FDKYG..........................VGKGTR............----ADVKYNSDVARAYRDKL----- ECA20874.1/12-98 ---LLAIRA.APGNDRCADC...GQPDP..EWASLNLGVVLCIRCGG..AHRSLGAHVSKVRSCTLDVrvWEPSVVEMFA.RWGNARANAV.WEGRG..........................DAA---............-------------------------- EBF92688.1/11-98 ---------.----------...--ADP..RWASANLGVFMCIRCSG..IHRSMGVHISFVRSVTMDS..WKEAQVRNMA.RWGNRKANEY.FEAAV..........................PRDYYI...........pSESDGIDVVERWIRDKV--------- ECE46318.1/124-264 ------LQE.MNQLVGCADC...GSKNL..EWVSINLGALLCIECSG..IHRSLGVHISKVRSLVLDD..LDEVTVQLLE.ATGNTEVNRV.WEAMHaglgsegghdnessddgasvtadlgsE----AqenehvagwikpTPTSDRATRERWIQAKYKWRGF---- ECL57426.1/143-223 ---VSELRA.IDGNACCADC...GAKHP..DWASVSNGTLLCMECAG..VHRGLGVHYSFVRSLTLDT..WSEKQLRKMH.AGGNEALRAA.FRKA-..........................------............-------------------------- ECC70659.1/52-118 --------A.QPGNARCFEC...SAHNP..SWASSKLGIFICLDCSG..RHRQLGVHLSFVRSVTMDK..WRPAELASMQ.AGGND-----.-----..........................------............-------------------------- ECI92226.1/45-156 --KLKEITK.RSENRRCMDC...LEKGP..RYVVLNFNIFVCSACSG..VHREF---QHRALGISMSK..FTWEQVNDLE.TGGNKAAKKL.WMARW..........................SPKDYP...........ePDGNDIPKIREFIRKKYVEKVWYKK- EBL27071.1/25-138 --EVEALAK.LPSNATCADC..gDAKRI..RFCSVTLGVFLCNRCYG..LHRALGAHVTRGKCLGLDA..WHPDEVNLLR.SVGNAGARAQ.FEANV..........................PAGVVR...........pTAASADRDVAAWIRDKYERKKYF--- EBS34338.1/54-127 ----GALLR.KTGNRACFDC...GSPCP..KWTSKNFGVFVCLDCSG..VHRSLGVHVSAVKSANMDR..WTDGELDVFRvTKGNDKA---.-----..........................------............-------------------------- ECI93303.1/4-79 -----EIFG.MPGNKVCVDC...PAKNP..QWATVTYGTLMCLECSG..LHRNLGVHLSFVRSIAMDS..WDERQIAAMR.KGGNQKWLDD.M----..........................------............-------------------------- ECJ07074.1/26-127 --------D.FPENNKCIDC...TAANP..QWASVSYGTYFCLGCSG..KHRGLGVHLSFVRSVTMDT..WKEVQKKKME.VGGNKAFREY.LQPYG..........................LAEAAIe.........vkYNSKAAEYYRDLIRHK---------- EDH19330.1/1-86 ---------.-------MDC...STKNP..QWASVSFGSFICLECSG..VHRSLGVHLSFVRSVGMDS..WNATQLKKMQ.LGGNAKVNQF.LAKHG..........................VPKDAP............IHLKYDSAAAE--------------- ECU44880.1/19-130 --KMRALSR.LPHNKRCFDC...TEKGP..NFVNLTLKTFVCSTCSG..ILREF---QHSSKSISMTT..FTMDMVKEFK.AGGNKRAKKV.WLARW..........................SPGEFP...........ePDPSEKSKIREFMRLKYEEKKWYKK- ECI79451.1/185-267 -----ELGA.APGNDKCADC...DAPNP..DWASLNLLVVICQRCAG..AHRHLGAHVSKVRSLALDRdaWTPPVRTLFL.ALGNTAANDV.WEAKR..........................R-----............-------------------------- ECN50331.1/59-90 ---------.----------...---QN..AWASINLGTFICFQCSG..IHRNLGTHLTKVR------..----------.----------.-----..........................------............-------------------------- ECN50331.1/111-184 ---------.----------...-----..-----------------..--RSASSCARQVRSLNLDS..WNDDWVANME.KWGNARCTAY.WEARP..........................PPRRPTl..........eDSNSQNHIHKAFIRDKYQDKLFAA-- ECI55684.1/18-87 ----AELERvDPQNAKCVDC...GENRP..LWASLSYGSYFCLECSG..VHRSLGVHLSFVRSVNMDS..WNEKQQRRMR.AGG-------.-----..........................------............-------------------------- ECE13052.1/4-27 ---------.-----RCADC...GATNP..TWLSLNLGVSVCIV---..-------------------..----------.----------.-----..........................------............-------------------------- ECE13052.1/46-125 ---------.----------...-----..-------------ACSG..IHRSLGVAVSKIRSLDMDS..IPVTQMEIVVnLGGNDKVNSVvWESGE..........................QRGWKK...........lNPDSNSDERRKYITAKYRWRGFV--- ECR66621.1/114-197 ---VSDFLA.MPGNDVCFDC...GASCAqdPWCSMTYAATICIKCAG..EHRGLGVHRSYVRSLALDT..LKPEEVRHLL.QGGNARFESF.LSELG..........................------............-------------------------- ECL69795.1/23-75 --TLRHLQS.EGANSICADC...DTKNP..QWASVSHGTFVCLECSG..AHRGLGVHVSFVRS-----..----------.----------.-----..........................------............-------------------------- ECK77775.1/36-152 -EAIKRARK.MQENKTCLTCsgpGSLAP..QYACVNFSIFICTRCAG..VYREFG---FRVKSVSAST..FTPEEVDAFVnGGGNENAKRK.YFAKY..........................DELKFP...........kPESNETSKIKGFVKAALLDKIWMED- ECS02714.1/40-113 ---------.TPGNERCFECstpLTPSD..AWVSVTCAVSLCPKCAG..LHRALGSHLSVVKSLSLDS..WIARDIERLT.RGGNSSCSSA.-----..........................------............-------------------------- EBB29202.1/6-96 ---------.----------...-TQAP..RSVCVPFGIFVCTRCSG..IFRDF---NFRIKSISAST..FSGDEVEMLK.RQGNDAARRT.FLARW..........................PQDRAL............PTSGDRVLGKNWIKAVFVDRMYY--- EBE24112.1/1-55 ---------.----------...-----..-------GIYLCHTCSG..KHRALGSHVSFIRSCTMDV..WRQDQLTVMD.LVGNSLFDTY.LRAEI..........................G-----............-------------------------- ECQ78338.1/6-95 --YLEDMLT.IPFNTYCVDC...KENKS..THAVVWLGAFVCKKCADdlVKKVGGNHHCYIKDIFGEH..WDDYQLQSMA.KGGNKNVFII.MKEYG..........................VHHEA-............-------------------------- ECT86020.1/1-70 ---------.----------...-----..-----------------..MHREF---NHKVKGISMSA..WSEEEAQMVM.QNGNTKDSDK.FLANF..........................SGTMPK............--GNDTAALRAFIKAKYDEKKWASD- #=GC PP_cons .66778888.99********...*999*..*****************..*******************..**********.********99.9*999..........................777776............8888888999999999999988776. #=GC RF 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