Summary: Jacalin-like lectin domain
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Jacalin-like lectin domain Edit Wikipedia article
|Jacalin-like lectin domain|
crystal structure of helianthus tuberosus lectin complexed to man(1-2)man
In molecular biology, the jacalin-like lectin domain is a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B-cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.
Database of jacalin like lectins and structure function relations. Proteins containing this domain include:
- Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus (jackfruit), which is specific for galactose.
- Artocarpin, a tetrameric plant seed lectin from A. heterophyllus.
- Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange).
- Heltuba lectin, a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke).
- Agglutinin from Calystegia sepium (Hedge bindweed).
- Griffithsin, an anti-viral lectin from red algae (Griffithsia species).
- Raval et al, "A database analysis of jacalin-like lectins: sequence–structure–function relationships" Glycobiology vol. 14 no. 12 pp. 1247–1263, 2004 http://glycob.oxfordjournals.org/content/14/12/1247.full.pdf
- Jeyaprakash AA, Geetha Rani P, Banuprakash Reddy G, Banumathi S, Betzel C, Sekar K, Surolia A, Vijayan M (August 2002). "Crystal structure of the jacalin-T-antigen complex and a comparative study of lectin-T-antigen complexes". J. Mol. Biol. 321 (4): 637–45. doi:10.1016/S0022-2836(02)00674-5. PMID 12206779.
- Jeyaprakash AA, Srivastav A, Surolia A, Vijayan M (May 2004). "Structural basis for the carbohydrate specificities of artocarpin: variation in the length of a loop as a strategy for generating ligand specificity". J. Mol. Biol. 338 (4): 757–70. doi:10.1016/j.jmb.2004.03.040. PMID 15099743.
- Lee X, Thompson A, Zhang Z, Ton-that H, Biesterfeldt J, Ogata C, Xu L, Johnston RA, Young NM (March 1998). "Structure of the complex of Maclura pomifera agglutinin and the T-antigen disaccharide, Galbeta1,3GalNAc". J. Biol. Chem. 273 (11): 6312–8. doi:10.1074/jbc.273.11.6312. PMID 9497359.
- Bourne Y, Zamboni V, Barre A, Peumans WJ, Van Damme EJ, Rouge P (December 1999). "Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins". Structure. 7 (12): 1473–82. doi:10.1016/s0969-2126(00)88338-0. PMID 10647178.
- Bourne Y, Roig-Zamboni V, Barre A, Peumans WJ, Astoul CH, Van Damme EJ, Rouge P (January 2004). "The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold". J. Biol. Chem. 279 (1): 527–33. doi:10.1074/jbc.M308218200. PMID 14561768.
- Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A (July 2006). "Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding". Structure. 14 (7): 1127–35. doi:10.1016/j.str.2006.05.017. PMID 16843894.
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Jacalin-like lectin domain Provide feedback
Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein (P15501).
Sankaranarayanan R, Sekar K, Banerjee R, Sharma V, Surolia A, Vijayan M; , Nat Struct Biol 1996;3:596-603.: A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a beta-prism fold. PUBMED:8673603 EPMC:8673603
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001229
The jacalin-like mannose-binding lectin domain has a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some proteins with this domain stimulate distinct T- and B- cell functions, such as the plant lectin jacalin, which binds to the T-antigen and acts as an agglutinin. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. While the family was initially named after an abundant protein found in the jackfruit seed, taxonomic distribution is not restricted to plants. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein. Proteins containing this domain include:
- Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus (jackfruit), which is specific for galactose [PUBMED:12206779].
- Artocarpin, a tetrameric plant seed lectin from A. heterophyllus [PUBMED:15099743].
- Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange), [PUBMED:9497359].
- Heltuba lectin, a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke) [PUBMED:10647178].
- Agglutinin from Calystegia sepium (Hedge bindweed) [PUBMED:14561768].
- Griffithsin, an anti-viral lectin from red algae (Griffithsia species) [PUBMED:16843894].
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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|Seed source:||Bateman A|
|Number in seed:||35|
|Number in full:||4054|
|Average length of the domain:||121.60 aa|
|Average identity of full alignment:||23 %|
|Average coverage of the sequence by the domain:||42.88 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||17|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Jacalin domain has been found. There are 271 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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