# STOCKHOLM 1.0 #=GF ID Mucin #=GF AC PF01456.18 #=GF DE Mucin-like glycoprotein #=GF AU Bateman A;0000-0002-6982-4660 #=GF GA 34.7 34.7 #=GF NC 34.6 34.3 #=GF TC 34.9 35.2 #=GF PI Tryp_mucin; #=GF SE Prodom_3102 (release 99.1) & Pfam-B_3837 (Release 8.0) #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 7592617 #=GF RT The protozoan Trypanosoma cruzi has a family of genes resembling #=GF RT the mucin genes of mammalian cells. #=GF RA Di Noia JM, Sanchez DO, Frasch AC; #=GF RL J Biol Chem 1995;270:24146-24149. #=GF RN [2] #=GF RM 9556557 #=GF RT The Trypanosoma cruzi mucin family is transcribed from hundreds #=GF RT of genes having hypervariable regions. #=GF RA Di Noia JM, D'Orso I, Aslund L, Sanchez DO, Frasch AC; #=GF RL J Biol Chem 1998;273:10843-10850. #=GF DR INTERPRO; IPR000458; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This family of trypanosomal proteins resemble vertebrate mucins. #=GF CC The protein consists of three regions. The N and C terminii are #=GF CC conserved between all members of the family, whereas the central #=GF CC region is not well conserved and contains a large number of #=GF CC threonine residues which can be glycosylated [1]. Indirect #=GF CC evidence suggested that these genes might encode the core #=GF CC protein of parasite mucins, glycoproteins that were proposed to #=GF CC be involved in the interaction with, and invasion of, mammalian #=GF CC host cells. This family contains an N-terminal signal peptide. #=GF SQ 1 F2UD61.1/1313-1470 CAQQHCCTARKtapplgllrvrpwavqyqqlqvwqqrhlacrqrllrrrcqqhqglqpwqlrlqqrtphachmqgqpslvppsqqqqqQQQQQQQQQQQQQQQQQTTTTTTTTTTTTTTTTTTTTTTTTTTTTTKVPICCWATLVSATAASVPSATNR //