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70  structures 2698  species 0  interactions 15310  sequences 255  architectures

Family: Glyco_transf_8 (PF01501)

Summary: Glycosyl transferase family 8

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Glycosyl transferase family 8 Provide feedback

This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase P27128 lipopolysaccharide glucosyltransferase 1 P27129 and glycogenin glucosyltransferase P46976.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002495

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([intenz:2.4.1.-]) and related proteins into distinct sequence based families has been described [ PUBMED:9334165 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

Glycosyltransferase family 8 CAZY comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase ( EC ), lipopolysaccharide glucosyltransferase 1 ( EC ), glycogenin glucosyltransferase ( EC ), inositol 1-alpha-galactosyltransferase ( EC ). These enzymes have a distant similarity to family GT_24.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(29)
Full
(15310)
Representative proteomes UniProt
(45239)
RP15
(2003)
RP35
(7389)
RP55
(13052)
RP75
(18572)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(29)
Full
(15310)
Representative proteomes UniProt
(45239)
RP15
(2003)
RP35
(7389)
RP55
(13052)
RP75
(18572)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(29)
Full
(15310)
Representative proteomes UniProt
(45239)
RP15
(2003)
RP35
(7389)
RP55
(13052)
RP75
(18572)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_730 (release 4.0) & Pfam-B_5903 (Release 7.5)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 29
Number in full: 15310
Average length of the domain: 240.10 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 51.90 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.3 24.3
Trusted cut-off 24.3 24.3
Noise cut-off 24.2 24.2
Model length: 256
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_transf_8 domain has been found. There are 70 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4LFW5 View 3D Structure Click here
A0A0G2K618 View 3D Structure Click here
A0A0N7KLT1 View 3D Structure Click here
A0A0P0VKK0 View 3D Structure Click here
A0A0P0WMK1 View 3D Structure Click here
A0A0P0X171 View 3D Structure Click here
A0A0P0XHK0 View 3D Structure Click here
A0A0P0XTD9 View 3D Structure Click here
A0A0R0EN86 View 3D Structure Click here
A0A0R0G8H7 View 3D Structure Click here
A0A0R0GCI8 View 3D Structure Click here
A0A0R0GJA9 View 3D Structure Click here
A0A0R0HNR3 View 3D Structure Click here
A0A0R0JRA3 View 3D Structure Click here
A0A0R0KPZ7 View 3D Structure Click here
A0A0R0KUR3 View 3D Structure Click here
A0A0R0KYU3 View 3D Structure Click here
A0A0R0L0I1 View 3D Structure Click here
A0A0R0L655 View 3D Structure Click here
A0A0R4J315 View 3D Structure Click here
A0A0R4J650 View 3D Structure Click here
A0A1D6ERW6 View 3D Structure Click here
A0A1D6ETS0 View 3D Structure Click here
A0A1D6F4J3 View 3D Structure Click here
A0A1D6F790 View 3D Structure Click here
A0A1D6GK94 View 3D Structure Click here
A0A1D6GWS4 View 3D Structure Click here
A0A1D6H8R1 View 3D Structure Click here
A0A1D6HAF0 View 3D Structure Click here
A0A1D6I9P8 View 3D Structure Click here
A0A1D6ILB6 View 3D Structure Click here
A0A1D6IMN1 View 3D Structure Click here
A0A1D6INX8 View 3D Structure Click here
A0A1D6IRJ1 View 3D Structure Click here
A0A1D6IXA3 View 3D Structure Click here
A0A1D6JSP6 View 3D Structure Click here
A0A1D6K1T4 View 3D Structure Click here
A0A1D6K3T7 View 3D Structure Click here
A0A1D6KEG2 View 3D Structure Click here
A0A1D6N5K0 View 3D Structure Click here
A0A1D6N6Y6 View 3D Structure Click here
A0A1D6NDF8 View 3D Structure Click here
A0A1D6NDF8 View 3D Structure Click here
A0A1D6PTT7 View 3D Structure Click here
A0A1D6QF22 View 3D Structure Click here
A0A1D8PCG4 View 3D Structure Click here
A0A1D8PKH2 View 3D Structure Click here
A0A286Y8Q8 View 3D Structure Click here
A0A2R8RIX2 View 3D Structure Click here
A0A368UGV8 View 3D Structure Click here
A0A368UHE2 View 3D Structure Click here
A0A368UIM2 View 3D Structure Click here
A0PJZ3 View 3D Structure Click here
A4QN62 View 3D Structure Click here
B4F8V6 View 3D Structure Click here
B4F9A1 View 3D Structure Click here
B4FA65 View 3D Structure Click here
B4FAM8 View 3D Structure Click here
B4FAR2 View 3D Structure Click here
B4FKY3 View 3D Structure Click here
B4FME6 View 3D Structure Click here
B4FRZ8 View 3D Structure Click here
B4G0X1 View 3D Structure Click here
B4G0Z8 View 3D Structure Click here
B6SVS0 View 3D Structure Click here
B6U4L9 View 3D Structure Click here
B7ZXA9 View 3D Structure Click here
B7ZZ35 View 3D Structure Click here
C0P3I7 View 3D Structure Click here
C4J490 View 3D Structure Click here
D4A275 View 3D Structure Click here
D4ADL7 View 3D Structure Click here
E7F0M8 View 3D Structure Click here
E7F9V4 View 3D Structure Click here
F1M570 View 3D Structure Click here
F4HZC3 View 3D Structure Click here
F4KED2 View 3D Structure Click here
H2KYQ5 View 3D Structure Click here
I1J6Q7 View 3D Structure Click here
I1J8Z3 View 3D Structure Click here
I1JBV6 View 3D Structure Click here
I1JDW9 View 3D Structure Click here
I1JF40 View 3D Structure Click here
I1JHP2 View 3D Structure Click here
I1JNZ9 View 3D Structure Click here
I1JQP9 View 3D Structure Click here
I1JTE2 View 3D Structure Click here
I1JTI9 View 3D Structure Click here
I1JWL9 View 3D Structure Click here
I1K4X8 View 3D Structure Click here
I1K7U4 View 3D Structure Click here
I1KD40 View 3D Structure Click here
I1KEF1 View 3D Structure Click here
I1KN63 View 3D Structure Click here
I1KWC6 View 3D Structure Click here
I1KY25 View 3D Structure Click here
I1KZ34 View 3D Structure Click here
I1L071 View 3D Structure Click here
I1L6S2 View 3D Structure Click here
I1L7S6 View 3D Structure Click here
I1LB22 View 3D Structure Click here
I1LBC7 View 3D Structure Click here
I1LSN3 View 3D Structure Click here
I1LUR4 View 3D Structure Click here
I1LWG0 View 3D Structure Click here
I1M3I1 View 3D Structure Click here
I1M3W5 View 3D Structure Click here
I1M6W5 View 3D Structure Click here
I1M8G3 View 3D Structure Click here
I1M8L8 View 3D Structure Click here
I1MFV2 View 3D Structure Click here
I1MRB3 View 3D Structure Click here
I1MT93 View 3D Structure Click here
I1MXP3 View 3D Structure Click here
I1MXU0 View 3D Structure Click here
I1N201 View 3D Structure Click here
I1N4I2 View 3D Structure Click here
I1N5Z5 View 3D Structure Click here
I1N6I1 View 3D Structure Click here
I1NBA3 View 3D Structure Click here
I1NBF3 View 3D Structure Click here
I1NBQ6 View 3D Structure Click here
I1NBZ7 View 3D Structure Click here
I1NBZ7 View 3D Structure Click here
I1NIS4 View 3D Structure Click here
K7KCB5 View 3D Structure Click here
K7KLI3 View 3D Structure Click here
K7KNE6 View 3D Structure Click here
K7KNQ7 View 3D Structure Click here
K7KV68 View 3D Structure Click here
K7L0E0 View 3D Structure Click here
K7L413 View 3D Structure Click here
K7LGC2 View 3D Structure Click here
K7LXL0 View 3D Structure Click here
K7M491 View 3D Structure Click here
K7MJ90 View 3D Structure Click here
K7MR54 View 3D Structure Click here
K7MTY9 View 3D Structure Click here
K7MU28 View 3D Structure Click here
K7MW71 View 3D Structure Click here
K7N057 View 3D Structure Click here
K7TQY8 View 3D Structure Click here
K7TW82 View 3D Structure Click here
K7VCZ8 View 3D Structure Click here
K7VE53 View 3D Structure Click here
K7W2N5 View 3D Structure Click here
O04253 View 3D Structure Click here
O04536 View 3D Structure Click here
O08730 View 3D Structure Click here
O15488 View 3D Structure Click here
O22693 View 3D Structure Click here
O22893 View 3D Structure Click here
O45819 View 3D Structure Click here
O45819 View 3D Structure Click here
O48684 View 3D Structure Click here
O80518 View 3D Structure Click here
O95461 View 3D Structure Click here
P27128 View 3D Structure Click here
P27129 View 3D Structure Click here
P36143 View 3D Structure Click here
P46976 View 3D Structure Click here
P47011 View 3D Structure Click here
Q09680 View 3D Structure Click here
Q0DD76 View 3D Structure Click here
Q0DN33 View 3D Structure Click here
Q0IRW1 View 3D Structure Click here
Q0J045 View 3D Structure Click here
Q0V7R1 View 3D Structure Click here
Q0WQD2 View 3D Structure Click here
Q0WV13 View 3D Structure Click here
Q10F74 View 3D Structure Click here
Q10L41 View 3D Structure Click here
Q10LZ0 View 3D Structure Click here
Q10MB0 View 3D Structure Click here
Q10MP3 View 3D Structure Click here
Q10Q30 View 3D Structure Click here
Q21389 View 3D Structure Click here
Q2QN55 View 3D Structure Click here
Q2RB54 View 3D Structure Click here
Q3U4G3 View 3D Structure Click here
Q3UHH8 View 3D Structure Click here
Q40710 View 3D Structure Click here
Q4DEE9 View 3D Structure Click here
Q4G148 View 3D Structure Click here
Q4PSY4 View 3D Structure Click here
Q54L24 View 3D Structure Click here
Q5JM51 View 3D Structure Click here
Q5NA53 View 3D Structure Click here
Q5SP46 View 3D Structure Click here
Q5U3H3 View 3D Structure Click here
Q5XPT3 View 3D Structure Click here
Q5Z7Z8 View 3D Structure Click here
Q640P4 View 3D Structure Click here
Q652K2 View 3D Structure Click here
Q66PG1 View 3D Structure Click here
Q66PG2 View 3D Structure Click here
Q68CQ7 View 3D Structure Click here
Q69QS2 View 3D Structure Click here
Q6AYF6 View 3D Structure Click here
Q6GX83 View 3D Structure Click here
Q6IQP1 View 3D Structure Click here
Q6IQP1 View 3D Structure Click here
Q6K3N8 View 3D Structure Click here
Q6NSU3 View 3D Structure Click here
Q6NV37 View 3D Structure Click here
Q6P7A1 View 3D Structure Click here
Q6Z5N7 View 3D Structure Click here
Q6ZGT9 View 3D Structure Click here
Q75IZ5 View 3D Structure Click here
Q7F1F3 View 3D Structure Click here
Q7X734 View 3D Structure Click here
Q7XHW0 View 3D Structure Click here
Q7XQR7 View 3D Structure Click here
Q7XYY1 View 3D Structure Click here
Q810K9 View 3D Structure Click here
Q8GWB7 View 3D Structure Click here
Q8GWT1 View 3D Structure Click here
Q8GWW4 View 3D Structure Click here
Q8H1S1 View 3D Structure Click here
Q8L4B0 View 3D Structure Click here
Q8LIF5 View 3D Structure Click here
Q8N3Y3 View 3D Structure Click here
Q8NBI6 View 3D Structure Click here
Q8RXE1 View 3D Structure Click here
Q8VYF4 View 3D Structure Click here
Q8W4A7 View 3D Structure Click here
Q93ZX7 View 3D Structure Click here
Q949Q1 View 3D Structure Click here
Q94HG3 View 3D Structure Click here
Q9FFA1 View 3D Structure Click here
Q9FH36 View 3D Structure Click here
Q9FWA4 View 3D Structure Click here
Q9FWY9 View 3D Structure Click here
Q9FXB2 View 3D Structure Click here
Q9FZ37 View 3D Structure Click here
Q9H1C3 View 3D Structure Click here
Q9LE59 View 3D Structure Click here
Q9LHD2 View 3D Structure Click here
Q9LN68 View 3D Structure Click here
Q9LSB1 View 3D Structure Click here
Q9LSG3 View 3D Structure Click here
Q9M8J2 View 3D Structure Click here
Q9M9Y5 View 3D Structure Click here
Q9R062 View 3D Structure Click here
Q9S7G2 View 3D Structure Click here
Q9SKT6 View 3D Structure Click here
Q9VBY3 View 3D Structure Click here
Q9Z1M7 View 3D Structure Click here
Q9ZPZ1 View 3D Structure Click here
Q9ZVI7 View 3D Structure Click here