Summary: Cation efflux family
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Cation efflux family Provide feedback
Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.
Xiong A, Jayaswal RK; , J Bacteriol 1998;180:4024-4029.: Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus. PUBMED:9696746 EPMC:9696746
Kunito T, Kusano T, Oyaizu H, Senoo K, Kanazawa S, Matsumoto S; , Biosci Biotechnol Biochem 1996;60:699-704.: Cloning and sequence analysis of czc genes in Alcaligenes sp. strain CT14. PUBMED:8829543 EPMC:8829543
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002524
Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells [PUBMED:9696746, PUBMED:8829543], however others are implicated in ion uptake [PUBMED:1508175]. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||cation transmembrane transporter activity (GO:0008324)|
|Biological process||transmembrane transport (GO:0055085)|
|cation transport (GO:0006812)|
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This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit . Many of these families contain a characteristic glycine rich motif close to the C-terminus.
The clan contains the following 20 members:Cation_efflux CRCB CRT-like DUF1632 DUF486 DUF606 DUF914 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp RhaT Sugar_transport TPT UAA UPF0060 UPF0546 Ureide_permease Zip
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Pfam-B_232 (release 4.0)|
|Number in seed:||89|
|Number in full:||12806|
|Average length of the domain:||268.50 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||81.33 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Cation_efflux domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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