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4  structures 8446  species 0  interactions 46212  sequences 450  architectures

Family: Acyltransferase (PF01553)

Summary: Acyltransferase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Phospholipid acyltransferase". More...

Phospholipid acyltransferase Edit Wikipedia article

OPM superfamily474
OPM protein5xj5

This family contains acyltransferases involved in phospholipid biosynthesis and proteins of unknown function.[1] This family also includes tafazzin,[2] the Barth syndrome gene.


Human proteins containing this domain



  1. ^ Neuwald AF (1997). "Barth syndrome may be due to an acyltransferase deficiency". Curr. Biol. 7 (8): R465–6. doi:10.1016/S0960-9822(06)00237-5. PMID 9259571.
  2. ^ Bolhuis PA, Toniolo D, Bione S, Maestrini E, Gedeon AK, D Adamo P (1996). "A novel X-linked gene, G4.5. is responsible for Barth syndrome". Nat. Genet. 12 (4): 385–389. doi:10.1038/ng0496-385. PMID 8630491.
This article incorporates text from the public domain Pfam and InterPro: IPR002123

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Acyltransferase Provide feedback

This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [1]. This family also includes tafazzin Q16635 the Barth syndrome gene [2].

Literature references

  1. Neuwald AF; , Curr Biol 1997;7:465-466.: Barth syndrome may be due to an acyltransferase deficiency. PUBMED:9259571 EPMC:9259571

  2. Bione S, D'Adamo P, Maestrini E, Gedeon AK, Bolhuis PA, Toniolo D; , Nat Genet 1996;12:385-389.: A novel X-linked gene, G4.5. is responsible for Barth syndrome. PUBMED:8630491 EPMC:8630491

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002123

This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [ PUBMED:9259571 ]. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [ PUBMED:18369234 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Acyltransferase (CL0228), which has the following description:

This clan includes several families of related acyltransferases.

The clan contains the following 5 members:

Acyltransf_2 Acyltransferase DAGAT DUF374 Lip_A_acyltrans


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_128 (release 4.0) & Pfam-B_5069 (Release 7.5)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 46
Number in full: 46212
Average length of the domain: 135.60 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 35.88 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.1 21.1
Trusted cut-off 21.1 21.1
Noise cut-off 21.0 21.0
Model length: 135
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Acyltransferase domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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