# STOCKHOLM 1.0 #=GF ID FAD_binding_4 #=GF AC PF01565.24 #=GF DE FAD binding domain #=GF AU Bateman A;0000-0002-6982-4660 #=GF GA 26.4 26.4 #=GF NC 26.3 26.3 #=GF TC 26.4 26.4 #=GF SE Pfam-B_352 (release 4.0) #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 9261083 #=GF RT Crystal structures and inhibitor binding in the octameric #=GF RT flavoenzyme vanillyl-alcohol oxidase: the shape of the #=GF RT active-site cavity controls substrate specificity. #=GF RA Mattevi A, Fraaije MW, Mozzarelli A, Olivi L, Coda A, van Berkel #=GF RA WJ; #=GF RL Structure 1997;5:907-920. #=GF RN [2] #=GF RM 8805513 #=GF RT The structure of the substrate-free form of MurB, an essential #=GF RT enzyme for the synthesis of bacterial cell walls. #=GF RA Benson TE, Walsh CT, Hogle JM; #=GF RL Structure 1996;4:47-54. #=GF DR INTERPRO; IPR006094; #=GF DR SCOP; 2vao; fa; #=GF DR PROSITE; PDOC00674; #=GF DC This is only a subset of the Pfam family #=GF DR HOMSTRAD; FAD-oxidase_NC; #=GF DR HOMSTRAD; FAD_binding_4; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This family consists of various enzymes that use FAD as a #=GF CC co-factor, most of the enzymes are similar to oxygen #=GF CC oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase #=GF CC (VAO) has a solved structure, the alignment includes the FAD #=GF CC binding site, called the PP-loop, between residues 99-110 [1]. #=GF CC The FAD molecule is covalently bound in the known structure, #=GF CC however the residue that links to the FAD is not in the #=GF CC alignment. VAO catalyses the oxidation of a wide variety of #=GF CC substrates, ranging form aromatic amines to 4-alkylphenols. #=GF CC Other members of this family include D-lactate dehydrogenase, #=GF CC this enzyme catalyses the conversion of D-lactate to pyruvate #=GF CC using FAD as a co-factor; mitomycin radical oxidase, this enzyme #=GF CC oxidises the reduced form of mitomycins and is involved in #=GF CC mitomycin resistance. This family includes MurB an #=GF CC UDP-N-acetylenolpyruvoylglucosamine reductase enzyme #=GF CC EC:1.1.1.158. This enzyme is involved in the biosynthesis of #=GF CC peptidoglycan [2]. #=GF SQ 23305 A0A498JSS5.1/330-468 PEFIFTPVHD.SH.VQAA.....V....I.........C......A....K....K...L...................R..I.H......L.R...V...R...S...G.G........H..D..YE..GLS.Yvs.............qiETPF...........LV..V...D.L..A..........K...LRT................-..I..S....V...DI........................................K.......SN..T..A..W..V..Q..A..G..A..T..I.G............E............L.......Y.....Y.R.I....A............E....K.............S...K........T.......L......G.......F......P......A............G............L........C...........T...........S............L.......G..........V............G....G......H........I........T.G...........G................A........Y......G...S..M............L..........R.......K...Y....G...L...GA......D....N..AV......DA....R..I....I...D..FN..GKIL--- A0A498JSS5.1/839-977 PEFIFTPLHD.SK.VQAA.....V....I.........C......S....K....K...L...................R..I.H......L.G...V...R...S...G.G........H..D..YE..GLS.Yvs.............qiETPF...........IV..I...D.L..A..........K...LRS................-..V..N....V...DI........................................K.......SN..T..A..W..I..Q..A..G..A..S..I.G............E............V.......Y.....Y.R.I....A............E....K.............N...Q........T.......H......G.......Y......P......A............G............L........C...........T...........S............L.......G..........I............G....E......H........I........T.G...........G................A........Y......G...S..M............M..........R.......K...Y....G...L...GA......D....N..AI......DA....R..I....I...D..VN..GQIL--- A0A498JSS5.1/1405-1490 ----------.--.----.....-....-.........-......-....-....-...-...................-..-.-......-.-...-...-...-...-.-........-..-..--..---.-.................----...........--..-...-.-..-..........A..dLNK................-..V..K....V...NR........................................G.......KR..T..A..W..V..Q..S..G..A..T..L.G............E............L.......Y.....Y.H.V....A............N....E............sR...G........K.......L......G.......F......T......A............G............V........C...........P...........T............I.......G..........V............G....G......H........I........S.G...........G................G........Q......G...V..L............M..........R.......K...F....G...L...SS......D....N..AV......DA....I..V....V...T..AD..GAVV--- A0A498JSS5.1/1873-2002 PLLLVRPFHE.SE.IQAA.....V....H.........C......S....K....K...L...................G..L.Q......V.R...V...R...S...G.G........H..D..YE..GLS.Yp...............sKTPF...........II..I...D.L..I..........N...LRY................-..I..E....V...NL........................................A.......DE..T..A..W..V..Q..S..G..A..T..L.G............E............L.......Y.....Y.S.I....A............K....K.............S...W........V.......H......G.......F......S......G............G............L........C...........P...........T............V.......G..........I............G....G......H........L........S.G...........G................G........F......G...I..L............I..........R.......K...H....G...L...AA......D....N..VV......DA....R..F....I...-..--..------- A0A498IUB9.1/293-431 PDFIFTPVHD.SH.VQAA.....V....I.........C......A....K....K...L...................R..I.H......L.R...F...R...S...G.G........H..D..YE..GLS.Yvs.............qiETPF...........AV..V...D.L..A..........N...LRS................-..V..S....V...DI........................................K.......SN..T..A..W..V..Q..A..G..A..T..I.G............E............L.......Y.....Y.R.I....A............E....K.............S...Q........T.......H......G.......Y......P......A............G............I........C...........T...........S............L.......G..........V............G....G......H........I........T.G...........G................A........Y......G...S..M............M..........R.......K...Y....G...L...GA......D....N..VV......DA....R..I....I...D..SN..GKIL--- A0A498IUB9.1/508-644 -QYIITPYLY.EH.VQAA.....I....I.........C......S....K....I...H...................R..F.Q......V.R...I...R...S...G.G........H..D..YE..ALS.Yk...............aDVPF...........II..I...D.L..F..........K...LNK................-..V..K....V...NS........................................K.......ER..T..A..W..V..Q..S..G..A..T..L.G............E............L.......Y.....Y.H.V....A............N....K............sR...G........K.......L......G.......F......T......A............G............V........C...........P...........T............I.......G..........V............G....G......H........I........S.G...........G................G........Q......G...V..L............M..........R.......K...F....G...L...SS......D....N..VV......DA....I..V....V...T..AN..GGIV--- A0A498IUB9.1/1011-1147 PLLLVTPSHE.SE.IQAA.....V....L.........C......S....R....K...L...................G..L.Q......V.R...V...R...S...G.G........H..D..YE..GLS.Yl...............cKTAF...........II..I...D.L..I..........N...LRS................-..L..K....V...NL........................................A.......DE..T..A..W..V..Q..S..G..A..T..L.G............E............L.......Y.....Y.S.I....A............M....K.............S...E........V.......H......G.......F......P......G............G............L........C...........P...........T............V.......G..........I............G....G......H........F........S.G...........G................G........F......G...T..Q............I..........R.......K...H....G...L...AA......D....N..VI......DA....R..L....I...D..VN..GRIL--- A0A2U1P4J4.1/144-280 PDVVVFPRSE.EE.VSKI.....V....R.........S......C....N....K...Y...................K..V.P......I.V...P...Y...G...G.A........T..S..IE..GHT.L................sPNGG...........VC..I...D.M..T..........L...MKS................V..K..A....L...HV........................................K.......DM..D..V..V..V..E..P..G..I..G..W.M............E............L.......N.....E.Y.L....A............P....Y.............G...L........F.......F......P.......L......D......P............G............P........G...........-...........-............A.......T..........I............G....G......M........C........A.T...........R................C........S......G...S..L............A..........V.......R...Y....G...T...MR......D....N..VI......NL....K..A....V...L..AD..GEVVKT- A0A2U1P4J4.1/623-759 PDVVVFPRSE.DE.VSKI.....V....Q.........F......C....N....K...Y...................K..V.S......I.V...P...Y...G...G.A........T..S..LE..GQT.L................sLNGG...........VC..I...D.M..T..........L...MKN................V..K..A....L...HV........................................K.......DM..D..V..V..V..E..P..G..I..G..W.M............D............L.......N.....E.Y.L....A............P....H.............G...L........F.......F......P.......L......D......P............G............P........G...........-...........-............A.......T..........I............G....G......M........C........G.T...........R................C........S......G...S..L............A..........V.......R...Y....G...T...MR......D....N..VI......SL....K..A....V...L..AD..GEVVKT- A0A4D8ZW03.1/49-185 PQVIITPEHE.SQ.IPSV.....V....R.........C......A....R....Q...S...................G..L.E......I.R...T...R...S...G.G........H..D..ME..GLS.Yv...............sQVSF...........VI..I...D.L..I..........N...LSD................-..V..T....V...NV........................................E.......EK..T..A..W..I..E..A..G..V..T..T.G............I............V.......Y.....Y.K.I....A............E....K.............S...P........T.......L......G.......F......P......G............A............I........F...........T...........K............V.......G..........V............C....G......H........F........S.G...........G................G........Y......E...A..M............V..........R.......K...H....G...L...AA......D....N..IV......DA....R..I....I...D..VH..GRII--- A0A4D8ZW03.1/537-673 PRVIITPEHE.SQ.IPPV.....I....R.........C......A....R....Q...S...................G..L.E......I.R...T...R...S...G.G........H..D..LE..GLS.Yv...............sQVPF...........VL..I...D.L..I..........N...LSE................-..V..T....V...NA........................................E.......EK..T..A..W..I..E..A..G..S..T..L.G............I............V.......Y.....Y.N.I....A............K....K.............S...S........T.......L......G.......F......P......G............G............V........C...........N...........T............V.......G..........V............G....G......H........F........S.G...........G................G........Y......G...T..L............M..........R.......K...Y....G...L...AG......D....N..VI......DA....R..I....I...D..VH..GRIL--- A0A4D8ZW03.1/1019-1155 PQVIITPEQE.SQ.IPPI.....V....R.........C......A....R....Q...T...................G..L.E......I.R...T...R...S...G.G........H..D..TE..GLS.Yv...............sQVPF...........VI..I...D.L..I..........N...ISE................-..V..K....V...NV........................................E.......DK..T..A..W..I..E..A..G..A..T..T.G............T............V.......Y.....Y.M.I....A............E....K.............S...P........T.......L......G.......F......P......G............A............I........F...........T...........T............V.......G..........V............G....G......H........Y........S.G...........G................G........Y......G...A..M............M..........R.......K...H....G...L...AG......D....N..VI......DA....R..I....I...D..VH..GRIL--- A0A2H5W3X0.1/41-177 PDVVVLPRTT.EQ.VARI.....V....Q.........V......C....V....R...E...................G..V.P......F.V...A...R...G...A.G........T..G..LS..GGA.L................pLAGG...........VL..I...A.L..N..........R...MDR................I..L..E....V...DY........................................P.......NL..R..A..V..V..E..P..G..V..I..N.A............R............L.......S.....E.A.L....A............S....R.............G...Y........Y.......Y......A.......P......D......P............A............S........Q...........T...........A............C.......T..........I............G....G......N........V........A.E...........N................S........G......G...P..R............T..........P.......K...Y....G...V...TT......H....H..VL......GL....E..V....V...L..PD..GEVV--- A0A2H5W3X0.1/518-655 PRLITWPRTV.EE.VSDI.....L....A.........L......A....C....R...H...................D..L.K......V.V...P...W...G...G.G........T..M..IG.lGRP.P.................LRVD...........LA..L...D.L..S..........D...LTG................V..V..D....Y...EP........................................A.......DM..T..A..S..F..R..A..G..T..T..L.Q............D............A.......Q.....A.L.L....A............A....H.............G...Q........F.......I......P.......L......D......P............P............G........A...........D...........R............A.......T..........L............G....G......I........L........A.T...........A................A........S......G...P..W............R..........H.......R...Y....G...T...PR......D....L..VL......AL....R..V....V...H..AD..GTVTR-- A0A0B6WSV1.1/39-177 PRAVVFPRST.EE.AAEV.....V....R.........T......L....A....R...H...................K..T.P......F.T...P...R...G...A.G........T..G..LS..GGA.T................aLDQS...........VI..I...E.L..S..........R...MRR................I..L..E....I...AP........................................E.......DR..L..A..V..V..E..T..G..V..I..N.A............H............L.......S.....R.A.A....A............P....F.............G...L........Y.......Y......A.......P......D......P............S............S........Q...........A...........T............C.......T..........I............G....G......N........I........A.E...........N................A........G......G...I..H............C..........L.......K...Y....G...V...TV......D....H..VL......AL....R..V....V...L..PD..GEIVQL- A0A0B6WSV1.1/534-668 --LIISPTSF.DQ.VSAV.....L....N.........L......A....Q....M...R...................G..W.S......I.V...P...A...G...S.M........T..W..LN..PSS.L.................-PSQ...........LV..L...S.T..R..........A...LAR................L..I..A....H...EP........................................A.......DL..V..V..T..A..E..A..G..L..T..F.Q............E............L.......N.....R.M.L....A............A....H.............N...Q........W.......L......P.......I......D......P............P............H........D...........E...........R............T.......T..........L............G....G......A........V........A.T...........G................I........D......G...P..Q............S..........L.......G...Y....G...E...MR......S....Y..VI......GM....R..V....A...L..AD..GRIIKA- A0A482V7W6.1/3-140 -QCVLKPKTT.DE.VSQI.....L....S.........F......C....N....D...Q...................K..L.A......V.S...P...Q...G...G.N........T..G..LV..GGS.V................pVFDE...........IV..L...S.L..N..........L...MKN................I..V..T....I...DD........................................T.......SG..I..L..V..C..E..S..G..C..V..L.E............Y............L.......D.....E.E.L....A............N....H.............G...L........M.......M......P.......L......D......L............G............A........K...........G...........S............C.......Q..........I............G....G......N........V........S.T...........N................A........G......G...L..R............L..........L.......R...Y....G...N...LQ......G....N..VL......GI....E..A....V...K..AN..GEVLDC- A0A482V7W6.1/705-840 --IVLKPKTT.EE.MSQI.....V....S.........Y......C....N....N...N...................R..L.A......V.C...P...Q...G...G.H........T..G..VV..GGA.T................pVFDE...........VI..I...S.T..E..........L...MNE................I..I..S....L...DE........................................K.......SG..I..L..T..C..Q..A..G..C..I..L.Q............N............V.......N.....D.Y.L....A............E....K.............N...L........I.......F......P.......L......D......L............G............A........K...........G...........S............C.......Q..........I............G....G......N........V........S.T...........N................A........G......G...L..R............V..........L.......K...Y....G...N...LH......G....N..VL......GL....E..V....V...Q..AD..GEILD-- A0A4Y7JUD9.1/78-214 PDLIITPLQE.SH.VQAA.....V....I.........C......S....R....K...Y...................G..L.Q......I.K...V...R...S...G.G........H..D..FE..GLS.Yi...............sDVPF...........II..V...D.M..F..........N...LRS................-..I..K....V...GV........................................R.......HK..Q..A..W..V..Q..S..G..A..T..L.G............E............V.......Y.....Y.R.I....A............E....K.............S...Q........T.......L......A.......F......P......A............G............P........A...........A...........T............V.......G..........V............G....G......H........L........S.G...........G................G........Y......G...Y..M............L..........R.......K...Y....G...M...AA......D....N..VI......NA....R..I....V...D..AN..GRLL--- A0A4Y7JUD9.1/416-506 ----------.--.----.....-....-.........-......-....-....-...-...................-..-.-......-.-...-...-...-...-.-........-..-..--..---.-.................---F...........II..V...D.L..F..........N...LRE................-..V..N....V...DV........................................K.......GK..V..A..W..V..Q..S..G..A..T..T.G............E............L.......Y.....Y.R.I....A............Q....K.............S...N........I.......L......A.......F......P......A............A............V........C...........T...........T............V.......G..........I............G....G......Y........I........S.G...........G................G........Y......G...A..M............L..........R.......K...F....G...T...AG......D....N..VI......DA....R..I....V...D..VH..GTIL--- A0A4Y7JUD9.1/909-1043 --LILTPLKE.SH.VQTA.....V....I.........C......S....R....K...H...................G..I.Q......I.K...V...R...S...G.G........H..D..FE..GLS.Yt...............sD--Vp.........fII..V...D.L..F..........N...LRK................-..I..N....V...DV........................................K.......GK..V..A..W..V..Q..S..G..A..T..T.G............E............L.......Y.....Y.E.I....A............K....K.............S...N........T.......L......A.......F......P......A............A............I........G...........T...........T............V.......G..........F............G....G......F........I........S.G...........G................G........Y......G...A..M............L..........R.......K...Y....G...T...AG......E....N..VI......DA....R..I....V...D..VH..GRIL--- A0A0L0C422.1/88-224 --LVLKPGST.QE.ISEI.....L....K.........Y......C....N....D...R...................R..L.A......V.C...P...Q...G...G.N........T..G..VA..GGS.V................pVFDE...........II..L...S.L..A..........R...LNK................I..I..S....I...DD........................................I.......TG..I..T..A..C..E..S..G..C..I..L.E............N............L.......D.....A.K.T....R............E....S.............G...L........I.......V......P.......L......D......L............G............A........K...........S...........S............C.......H..........I............G....G......N........V........S.T...........N................A........G......G...L..R............V..........V.......R...Y....G...N...LH......G....S..VL......GL....E..A....V...L..AD..GKVLDL- A0A0L0C422.1/589-725 --LVLKPGST.QE.ISEI.....L....K.........Y......C....N....D...K...................R..L.A......V.C...P...Q...G...G.N........T..G..LV..GGS.V................pVCDE...........IV..L...S.L..A..........R...LNK................I..I..S....I...DD........................................I.......TG..I..T..A..C..E..S..G..C..I..L.E............N............L.......D.....A.K.T....R............E....A.............G...L........V.......V......P.......I......D......L............G............A........K...........S...........S............C.......H..........I............G....G......N........I........S.T...........N................A........G......G...L..R............V..........I.......R...Y....G...N...LH......G....S..VL......GV....E..A....V...L..AD..GKVLDL- A0A0A7LDV0.1/38-173 -EACVAPSST.ED.VSKI.....V....A.........I......A....R....K...N...................N..V.K......V.V...S...S...N...N.P........S..W..AI.dGTK.C.................GNSV...........VF..V...D.L..S..........N...INS................I..I..K....I...DP........................................V.......SL..T..V..R..V..G..A..G..C..K..F.E............T............L.......A.....G.A.C....S............E....A.............G...F........T.......L......G.......S......Y......P............F............D........W...........S...........-............S.......T..........V............G....A......W........A........V.T...........N................G........I......G...Y..G............V..........Y.......K...Y....G...N...SR......D....N..VV......NI....K..A....V...T..EN..AATIE-- A0A0A7LDV0.1/428-567 PDVVVRPSTV.SH.ISQI.....V....K.........I......A....H....K...K...................G..I.P......V.V...P...R...G...N.S........S..W..GL..GGC.M................pANAG...........IV..L...D.L..A..........S..kMNK................V..M..E....I...NT........................................E.......EM..Y..V..K..V..G..S..G..C..T..W.K............E............V.......L.....D.K.C....M............K....K.............G...Y........I.......I......G.......S......Y......P............S............S........F...........P...........S............A.......T..........I............G....A......W........I........A.T...........N................G........M......G...I..G............S..........Y.......K...Y....G...S...AK......D....N..VL......NM....E..V....V...L..SN..GDMLET- A5UTQ1.1/43-182 PDGVVFPRSV.DE.VVQL.....V....R.........W......A....A....R...H...................Q..I.P......L.I...A...R...G...S.G........T..G..LA..GGA.V................pEHGG...........VV..V...Q.L..G..........L...MNH................V..L..D....I...DL........................................T.......GR..S..A..V..V..E..A..G..V..V..N.L............I............F.......D.....T.R.V....R............Q....H.............G...L........F.......F......P.......P......D......P............S............S........Q...........R...........T............A.......T..........I............G....G......N........I........G.T...........N................A........G......G...P..H............C..........F.......K...Y....G...V...TS......N....Y..VT......GV....E..V....V...L..SD..GRIIHTG A5UTQ1.1/498-630 --VLIAPESA.EE.AAER.....L....R.........D......L....T....S...A...................G..Q.S......V.R...I...R...G...G.G........T..K..SA..LLP.-.................-PAD...........AV..V...S.T..A..........H...LSG................I..R..V....L...AP........................................D.......DL..Y..I..T..V..G..A..G..T..C..L.E............E............L.......Q.....K.A.V....H............P....Y.............G...M........W.......A......P.......I......-......A............S............P........W...........S...........T............A.......T..........I............G....G......T........I........A.A...........N................L........N......A...P..L............R..........M.......R...Y....G...S...LR......D....L..IL......AA....T..V....A...L..PN..GRVARI- A0A4Y7I7W9.1/44-117 ---ILIPLDE.SH.VQTA.....V....V.........C......S....R....K...H...................G..V.Q......I.K...V...R...S...G.G........H..D..YE..GLS.Yt...............sD--Vp.........fII..V...D.L..F..........N...LRD................-..I..N....V...DV........................................K.......GK..A..A..W..V..Q..S..G..A..T..T.G............K............-.......-.....-.-.-....-............-....-.............-...-........-.......-......-.......-......-......-............-............-........-...........-...........-............-.......-..........-............-....-......-........-........-.-...........-................-........-......-...-..-............-..........-.......-...-....-...-...--......-....-..--......--....-..-....-...-..--..------- A0A4Y7I7W9.1/239-354 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PLAAVCPTTT.EQ.VAAV.....M....K.........L......A....K....E...E...................G..L.T......V.T...P...R...G...A.G........T..G..LS..GMA.V................pVKGG...........LV..L...D.M..A..........R...MNK................I..K..S....I...RI........................................E.......DR..V..V..V..V..E..P..G..V..V..Y.G............D............L.......A.....K.E.L....A............P....H.............G...F........A.......F......P.......P......D......P............S............S........G...........V...........V............A.......T..........I............G....G......N........V........A.T...........D................A........G......G...I..K............G..........A.......K...Y....G...T...TK......D....Y..VM......AL....E..V....V...L..PD..GRVMRTG A0A017H6J1.1/48-186 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PLIVVLPETV.EQ.VAAV.....L....K.........Y......C....H....Q...N...................S..V.K......V.V...P...R...G...A.G........T..S..LS..GGA.L................pLADG...........VL..L...S.L..T..........K...FKQ................I..L..E....L...DY........................................E.......NR..C..A..R..V..Q..P..G..V..T..N.L............A............I.......S.....Q.A.V....D............A....D.............G...Y........Y.......Y......A.......P......D......P............S............S........Q...........I...........A............C.......T..........I............G....G......N........V........A.E...........N................A........G......G...V..H............C..........L.......K...Y....G...L...TT......N....N..LL......GL....E..L....V...T..IE..GEIIRI- T2GF69.1/48-185 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PLAIALPATV.QE.VQAI.....V....R.........W......A....N....D...A...................H..I.A......I.V...P...S...G...G.R........T..G..LS..GGA.M................aTNGE...........LV..L...S.L..E..........R...MNK................M..L..R....F...DP........................................M.......DR..T..M..T..V..Q..A..G..M..P..L.E............A............V.......Q.....A.A.A....R............Q....H.............G...L........L.......Y......P.......V......D......F............A............A........R...........G...........S............C.......S..........I............G....G......T........I........A.T...........N................A........G......G...I..R............V..........V.......R...Y....G...N...TR......E....W..IA......GL....N..V....V...T..GT..GELLTL- K7SFL5.1/40-179 PEAVLFPRHE.GD.VSDI.....L....K.........Y......C....N....E...H...................R..I.V......I.V...P...R...G...A.G........S..G..FT..GGA.L................pSSGG...........IV..L...A.F..E..........K..hMNK................I..L..E....I...DM........................................Q.......NM..V..A..I..V..Q..P..G..V..V..N.M............E............L.......Q.....R.A.V....E............A....V.............G...L........F.......Y......P.......P......D......P............A............S........Q...........E...........Y............S.......T..........I............G....G......N........V........N.E...........N................A........G......G...M..R............A..........A.......K...Y....G...I...TK......D....Y..VM......AM....R..A....V...L..PN..GDIIKA- D1C769.1/53-187 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PRAVVFPNNT.EE.VAKI.....V....K.........Y......C....H....E...H...................D..L.P......F.L...A...R...G...A.G........T..G..LS..GGA.I................pLNGE...........VI..I...S.L..V..........K...MKR................L..I..S....V...DF........................................E.......NR..R..A..V..V..E..P..G..F..V..N.L............K............L.......T.....N.S.I....S............D....K.............G...Y........Y.......Y......A.......P......D......P............S............S........Q...........Y...........C............C.......T..........I............G....G......N........V........G.E...........N................A........G......G...A..H............C..........L.......K...Y....G...V...TT......N....H..IL......GL....E..V....V...L..PN..GEVIEI- D1CDS6.1/41-179 PTAVVLPETT.EQ.VQAI.....V....K.........L......C....H....R...H...................K..I.P......F.V...A...R...G...S.G........T..G..LS..GGA.M................pVEEG...........IL..I...S.L..S..........R...MRR................I..L..E....V...DI........................................P.......NQ..R..V..V..V..E..P..G..V..I..N.L............W............V.......T.....Q.A.V....S............Q....Y.............G...Y........Y.......Y......A.......P......D......P............S............S........Q...........L...........I............C.......S..........I............G....G......N........V........A.E...........N................S........G......G...A..H............C..........L.......K...Y....G...F...TT......N....H..VT......GL....E..V....V...L..PD..GEIIHI- A0A1X1Q914.1/41-180 PDVVVSPGNV.QE.VSAI.....M....K.........F......A....N....E...H...................K..I.P......V.Y...P...R...G...S.G........T..N..LS.aGTA.P.................LKGG...........IV..L...L.M..L..........R...FNK................I..I..D....L...DL........................................E.......NL..I..A..E..V..E..V..G..V..V..V.Q............D............I.......N.....D.Y.V....A............P....H.............G...L........I.......Y......P.......P......D......P............G............T........V...........K...........T............A.......S..........L............G....G......T........I........C.E...........N................S........G......G...L..R............G..........L.......K...Y....G...I...TK......N....Y..VQ......GL....E..V....V...L..AN..GDIIHTG A0A1T5BW76.1/40-177 PMAVVLPRDA.TD.VSMI.....V....R.........C......A....S....K...H...................N..I.P......L.I...P...R...G...A.G........T..S..LA..GQV.V.................-GNG...........MV..V...D.I..S..........H..hMNR................I..I..E....V...NA........................................D.......EN..W..V..T..V..E..P..G..V..V..L.D............D............L.......N.....R.K.A....T............E....Y.............G...L........F.......F......G.......P......E......T............S............T........S...........N...........R............C.......T..........L............G....G......M........V........A.N...........N................S........C......G...S..H............S..........M.......I...Y....G...S...TR......D....H..II......EV....T..G....F...L..AN..GEEVTF- C8W3B0.1/44-182 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PEVVFMATTT.EE.VAAV.....M....K.........I......C....N....E...N...................K..I.P......V.T...P...R...G...S.G........S..G..LV..GGA.V................pLLGG...........VL..I...D.L..S..........K...MNK................I..L..S....Y...DL........................................E.......NF..V..V..H..V..Q..P..G..V..S..L.N............D............L.......A.....E.D.C....A............K....Q.............G...L........L.......Y......A.......P......D......P............G............E........K...........F...........-............A.......H..........L............G....G......N........V........S.T...........N................A........G......G...M..R............A..........V.......K...Y....G...A...TR......D....Y..VR......AM....T..V....V...L..PS..GEITNF- A0A369QR87.1/35-171 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PEAAVFPQNR.EQ.VAEV.....V....K.........L......A....N....K...E...................N..I.P......V.T...P...R...G...A.G........T..G..LA..AGA.V................pLYGG...........IV..L...S.L..E..........K...MNR................I..L..E....V...NH........................................E.......HL..Y..M..I..V..E..P..G..V..R..T.Q............D............V.......Q.....K.A.A....A............D....A.............G...L........L.......Y......A.......G......D......P............S............S........G...........D...........N............C.......L..........I............G....G......N........I........A.T...........N................A........G......G...N..K............A..........V.......K...Y....G...T...TR......Q....Q..VY......AI....E..V....V...T..PT..GEITEL- A0A1W2CVH8.1/43-182 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