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49  structures 7754  species 0  interactions 14014  sequences 109  architectures

Family: PMSR (PF01625)

Summary: Peptide methionine sulfoxide reductase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Peptide methionine sulfoxide reductase Provide feedback

This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.

Literature references

  1. Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR; , Proc Natl Acad Sci USA 1996;93:7985-7990.: Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens. PUBMED:8755589 EPMC:8755589

  2. Moskovitz J, Weissbach H, Brot N; , Proc Natl Acad Sci U S A 1996;93:2095-2099.: Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins. PUBMED:8700890 EPMC:8700890

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002569

Peptide methionine sulphoxide reductase (Msr) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, Met(O), to methionine [ PUBMED:10841552 ]. It is present in most living organisms, and the cognate structural gene belongs to the so-called minimum gene set [ PUBMED:8994848 , PUBMED:8816789 ].

The domains MsrA and MsrB reduce different epimeric forms of methionine sulphoxide. This group represent MsrA, the crystal structure of which has been determined in a number of organisms. In Mycobacterium tuberculosis, the MsrA structure has been determined to 1.5 Angstrom resolution [ PUBMED:12837786 ]. In contrast to the three catalytic cysteine residues found in previously characterised MsrA structures, M. tuberculosis MsrA represents a class containing only two functional cysteine residues. The overall structure shows no resemblance to the structures of MsrB ( INTERPRO ) from other organisms; though the active sites show approximate mirror symmetry. In each case, conserved amino acid motifs mediate the stereo-specific recognition and reduction of the substrate.

In a number of pathogenic bacteria including Neisseria gonorrhoeae, the MsrA and MsrB domains are fused; the MsrA being N-terminal to MsrB. This arrangement is reversed in Treponema pallidum. In N. gonorrhoeae and Neisseria meningitidis a thioredoxin domain is fused to the N terminus. This may function to reduce the active sites of the downstream MsrA and MsrB domains.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

Representative proteomes UniProt

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

Representative proteomes UniProt
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1111 (release 4.1)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 590
Number in full: 14014
Average length of the domain: 148.9 aa
Average identity of full alignment: 41 %
Average coverage of the sequence by the domain: 68.61 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.3 22.3
Trusted cut-off 22.5 22.3
Noise cut-off 22.1 22.2
Model length: 153
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PMSR domain has been found. There are 49 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044R3H8 View 3D Structure Click here
A0A077ZI59 View 3D Structure Click here
A0A0D2GKJ4 View 3D Structure Click here
A0A0H3GHE5 View 3D Structure Click here
A0A0K0EKP3 View 3D Structure Click here
A0A0R0FA73 View 3D Structure Click here
A0A175WBQ7 View 3D Structure Click here
A0A1C1CNN3 View 3D Structure Click here
A0A1D6K8P1 View 3D Structure Click here
A0JXQ4 View 3D Structure Click here
A1AWS4 View 3D Structure Click here
A1R7D2 View 3D Structure Click here
A1TH24 View 3D Structure Click here
A1UNG1 View 3D Structure Click here
A4HTE0 View 3D Structure Click here
A4X3E5 View 3D Structure Click here
A4XPS6 View 3D Structure Click here
A5I348 View 3D Structure Click here
A5VKT1 View 3D Structure Click here
A6Q418 View 3D Structure Click here
A6TUE9 View 3D Structure Click here
A6WYH5 View 3D Structure Click here
A8FEA4 View 3D Structure Click here
A8IPQ8 View 3D Structure Click here
A8L177 View 3D Structure Click here
A9KPX7 View 3D Structure Click here
A9MEZ2 View 3D Structure Click here
B0RBB1 View 3D Structure Click here
B0UCG5 View 3D Structure Click here
B2HLR5 View 3D Structure Click here
B2VHZ5 View 3D Structure Click here
B3PND9 View 3D Structure Click here
B4FGU9 View 3D Structure Click here
B6IS04 View 3D Structure Click here
B6TNT5 View 3D Structure Click here
B7K079 View 3D Structure Click here
B8IJD1 View 3D Structure Click here
B9DRF3 View 3D Structure Click here
B9LA36 View 3D Structure Click here
C0NBI3 View 3D Structure Click here