Summary: Glycosyltransferase family 92
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Glycosyltransferase family 92 Provide feedback
Members of this family act as galactosyltransferases, belonging to glycosyltransferase family 92 [1,2,3]. The aligned region contains several conserved cysteine residues and several charged residues that may be catalytic residues. This is supported by the inclusion of this family in the GT-A glycosyl transferase superfamily.
Literature references
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Titz A, Butschi A, Henrissat B, Fan YY, Hennet T, Razzazi-Fazeli E, Hengartner MO, Wilson IB, Kunzler M, Aebi M;, J Biol Chem. 2009;284:36223-36233.: Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. PUBMED:19858195 EPMC:19858195
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Suzuki N, Yamamoto K;, J Biol Chem. 2010;285:5178-5187.: Molecular cloning of pigeon UDP-galactose beta-D-galactoside alpha1,4-galactosyltransferase and UDP-galactose beta-D-galactoside and.. PUBMED:19959475 EPMC:19959475
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Hansen SF, Harholt J, Oikawa A, Scheller HV;, Front Plant Sci. 2012;3:59.: Plant Glycosyltransferases Beyond CAZy: A Perspective on DUF Families. PUBMED:22629278 EPMC:22629278
Internal database links
SCOOP: | Glyco_tranf_2_4 Glycos_transf_2 |
Similarity to PfamA using HHSearch: | Glyco_tranf_2_4 |
External database links
CAZY: | GT92 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR008166
This entry represents the glycosyltransferase family 92 [ PUBMED:19858195 , PUBMED:19959475 , PUBMED:22629278 ]. The aligned region contains several conserved cysteine residues and several charged residues that may be catalytic residues. This is supported by the inclusion of this family in the GT-A glycosyl transferase superfamily.
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan GT-A (CL0110), which has the following description:
This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].
The clan contains the following 53 members:
Anp1 Branch Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 DUF6564 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_15 Glyco_transf_21 Glyco_transf_24 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_88 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Osmo_MPGsynth Pox_P35 RGP Rhamno_transf STELLO TcdA_TcdB UDP-g_GGTase UDPGPAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (49) |
Full (4365) |
Representative proteomes | UniProt (7391) |
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RP15 (1558) |
RP35 (2613) |
RP55 (4021) |
RP75 (4787) |
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Jalview | |||||||
HTML | |||||||
PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
not generated,
— not available.
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (49) |
Full (4365) |
Representative proteomes | UniProt (7391) |
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RP15 (1558) |
RP35 (2613) |
RP55 (4021) |
RP75 (4787) |
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Raw Stockholm | |||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Pfam-B_1694 (release 4.1) |
Previous IDs: | DUF23; |
Type: | Domain |
Sequence Ontology: | SO:0000417 |
Author: |
Bashton M |
Number in seed: | 49 |
Number in full: | 4365 |
Average length of the domain: | 226.1 aa |
Average identity of full alignment: | 17 % |
Average coverage of the sequence by the domain: | 48.89 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 258 | ||||||||||||
Family (HMM) version: | 30 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Selections
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
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AlphaFold Structure Predictions
The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.
trRosetta Structure
The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.
The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.
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