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52  structures 6016  species 0  interactions 42200  sequences 313  architectures

Family: Na_Ca_ex (PF01699)

Summary: Sodium/calcium exchanger protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Sodium/calcium exchanger protein Provide feedback

This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [2]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [2]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [1] see Q01728 P48768 and P70549 respectively.

Literature references

  1. Nicoll DA, Quednau BD, Qui Z, Xia YR, Lusis AJ, Philipson KD; , J Biol Chem 1996;271:24914-24921.: Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. PUBMED:8798769 EPMC:8798769

  2. Nicoll DA, Longoni S, Philipson KD; , Science 1990;250:562-565.: Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. PUBMED:1700476 EPMC:1700476


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004837

The sodium/calcium exchangers are a family of integral membrane proteins. This domain covers the integral membrane regions of these proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [ PUBMED:1700476 ]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [ PUBMED:1700476 ]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [ PUBMED:8798769 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(91)
Full
(42200)
Representative proteomes UniProt
(129137)
RP15
(6258)
RP35
(18948)
RP55
(37194)
RP75
(56736)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(91)
Full
(42200)
Representative proteomes UniProt
(129137)
RP15
(6258)
RP35
(18948)
RP55
(37194)
RP75
(56736)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(91)
Full
(42200)
Representative proteomes UniProt
(129137)
RP15
(6258)
RP35
(18948)
RP55
(37194)
RP75
(56736)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1680 (release 4.1)
Previous IDs: Na_Ca_Ex;
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A , Eberhardt R
Number in seed: 91
Number in full: 42200
Average length of the domain: 150.40 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 53.22 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.9 22.0
Trusted cut-off 24.9 22.0
Noise cut-off 24.8 21.9
Model length: 151
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Na_Ca_ex domain has been found. There are 52 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096PXB4 View 3D Structure Click here
A0A096PXB4 View 3D Structure Click here
A0A0B4K6E2 View 3D Structure Click here
A0A0B4K6E2 View 3D Structure Click here
A0A0G2K3S9 View 3D Structure Click here
A0A0G2K3S9 View 3D Structure Click here
A0A0P0XYH1 View 3D Structure Click here
A0A0P0YCN6 View 3D Structure Click here
A0A0R0ETK5 View 3D Structure Click here
A0A0R0ETK5 View 3D Structure Click here
A0A0R0FJI5 View 3D Structure Click here
A0A0R0FJI5 View 3D Structure Click here
A0A0R0HIN5 View 3D Structure Click here
A0A0R0I941 View 3D Structure Click here
A0A0R0I941 View 3D Structure Click here
A0A0R0IWP5 View 3D Structure Click here
A0A0R0IWP5 View 3D Structure Click here
A0A0R0IZQ9 View 3D Structure Click here
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A0A0R0JTB9 View 3D Structure Click here
A0A0R0JTB9 View 3D Structure Click here
A0A0R0KFB7 View 3D Structure Click here
A0A0R0KFB7 View 3D Structure Click here
A0A0R0KLZ0 View 3D Structure Click here
A0A0R0KLZ0 View 3D Structure Click here
A0A1D5NSH8 View 3D Structure Click here
A0A1D6E1G2 View 3D Structure Click here
A0A1D6FCQ6 View 3D Structure Click here
A0A1D6FCQ6 View 3D Structure Click here
A0A1D6FLS5 View 3D Structure Click here
A0A1D6FLS5 View 3D Structure Click here
A0A1D6GL70 View 3D Structure Click here
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A0A1D6H079 View 3D Structure Click here
A0A1D6H079 View 3D Structure Click here
A0A1D6H5N4 View 3D Structure Click here
A0A1D6H5N4 View 3D Structure Click here
A0A1D6ITN9 View 3D Structure Click here
A0A1D6JG60 View 3D Structure Click here
A0A1D6JG60 View 3D Structure Click here
A0A1D6K577 View 3D Structure Click here
A0A1D6K577 View 3D Structure Click here
A0A1D6KGN1 View 3D Structure Click here
A0A1D6MNH0 View 3D Structure Click here
A0A1D6MNH0 View 3D Structure Click here
A0A1D8PFN3 View 3D Structure Click here
A0A1D8PFN3 View 3D Structure Click here
A0A1D8PUA3 View 3D Structure Click here
A0A1D8PUA3 View 3D Structure Click here
A0A286Y8H6 View 3D Structure Click here
A0A286Y8H6 View 3D Structure Click here
A0A2R8PV75 View 3D Structure Click here
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A0A2R8PY30 View 3D Structure Click here
A0A2R8PY30 View 3D Structure Click here
A0A2R8QH51 View 3D Structure Click here
A0A2R8QH51 View 3D Structure Click here
A0A368UI15 View 3D Structure Click here
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A1Z7I1 View 3D Structure Click here
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A1ZAJ4 View 3D Structure Click here
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A4UQV6 View 3D Structure Click here
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B0V3S7 View 3D Structure Click here
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B6UEI1 View 3D Structure Click here
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C0PDK2 View 3D Structure Click here
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C6KSN3 View 3D Structure Click here
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G5EF08 View 3D Structure Click here
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H2KYP2 View 3D Structure Click here
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I1J7G3 View 3D Structure Click here
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I1JHC6 View 3D Structure Click here
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I1LV45 View 3D Structure Click here
I1M329 View 3D Structure Click here
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I1M610 View 3D Structure Click here
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I1MBA7 View 3D Structure Click here
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I1MC89 View 3D Structure Click here
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K7MQ98 View 3D Structure Click here
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O04034 View 3D Structure Click here
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O16241 View 3D Structure Click here
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O53910 View 3D Structure Click here
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O54701 View 3D Structure Click here
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O59768 View 3D Structure Click here
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O60721 View 3D Structure Click here
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P31801 View 3D Structure Click here
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P32418 View 3D Structure Click here
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P34315 View 3D Structure Click here
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P34322 View 3D Structure Click here
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P42839 View 3D Structure Click here
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P45394 View 3D Structure Click here
P45394 View 3D Structure Click here
P47144 View 3D Structure Click here
P47144 View 3D Structure Click here
P48768 View 3D Structure Click here
P48768 View 3D Structure Click here
P57103 View 3D Structure Click here
P57103 View 3D Structure Click here
P70414 View 3D Structure Click here
P70414 View 3D Structure Click here
P70549 View 3D Structure Click here
P70549 View 3D Structure Click here
P87122 View 3D Structure Click here
P87122 View 3D Structure Click here
P90858 View 3D Structure Click here
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Q01728 View 3D Structure Click here
Q01728 View 3D Structure Click here
Q12424 View 3D Structure Click here
Q12424 View 3D Structure Click here
Q14BI1 View 3D Structure Click here
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Q2R041 View 3D Structure Click here
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Q2RAK6 View 3D Structure Click here
Q32SG7 View 3D Structure Click here
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Q337V5 View 3D Structure Click here
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Q39253 View 3D Structure Click here
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Q49SH1 View 3D Structure Click here
Q49SH1 View 3D Structure Click here
Q54LH1 View 3D Structure Click here
Q54LH1 View 3D Structure Click here
Q54WZ6 View 3D Structure Click here
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Q54YQ8 View 3D Structure Click here
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Q57556 View 3D Structure Click here
Q57556 View 3D Structure Click here
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Q5A016 View 3D Structure Click here
Q5A016 View 3D Structure Click here
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Q5RH62 View 3D Structure Click here
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Q5TKG3 View 3D Structure Click here
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Q6AXS0 View 3D Structure Click here
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Q6H641 View 3D Structure Click here
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Q6K1C4 View 3D Structure Click here
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Q6K3R5 View 3D Structure Click here
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Q6YXZ1 View 3D Structure Click here
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Q71RS6 View 3D Structure Click here
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Q7PLW4 View 3D Structure Click here
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Q7Y0B2 View 3D Structure Click here
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Q8C261 View 3D Structure Click here
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Q8CGQ8 View 3D Structure Click here
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Q8GS69 View 3D Structure Click here
Q8GS69 View 3D Structure Click here
Q8K596 View 3D Structure Click here
Q8K596 View 3D Structure Click here
Q8L636 View 3D Structure Click here
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Q8L783 View 3D Structure Click here
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Q8NFF2 View 3D Structure Click here
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Q8SZV0 View 3D Structure Click here
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Q91WD8 View 3D Structure Click here
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Q925Q3 View 3D Structure Click here
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Q99385 View 3D Structure Click here
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Q99PD7 View 3D Structure Click here
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Q9QZM6 View 3D Structure Click here
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Q9SYG9 View 3D Structure Click here
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Q9UI40 View 3D Structure Click here
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