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27  structures 4261  species 0  interactions 10044  sequences 83  architectures

Family: BolA (PF01722)

Summary: BolA-like protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "BolA-like protein family". More...

BolA-like protein family Edit Wikipedia article

BolA
PDB 1ny8 EBI.jpg
solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115
Identifiers
SymbolBolA
PfamPF01722
InterProIPR002634
SCOP21v9j / SCOPe / SUPFAM

In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli and its various homologs. In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[1] The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase.[1] BolA is also induced by stress during early stages of growth [1] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[2][1]

References

  1. ^ a b c d Santos JM, Freire P, Vicente M, Arraiano CM (1999). "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. PMID 10361282. {{cite journal}}: C1 control character in |pages= at position 5 (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid10361282" was defined multiple times with different content (see the help page). Cite error: The named reference "pmid10361282" was defined multiple times with different content (see the help page). Cite error: The named reference "pmid10361282" was defined multiple times with different content (see the help page).
  2. ^ Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR (1989). "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene". EMBO J. 8 (12): 3923–31. PMC 402084. PMID 2684651. {{cite journal}}: C1 control character in |pages= at position 6 (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
This article incorporates text from the public domain Pfam and InterPro: IPR002634

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BolA-like protein Provide feedback

This family consist of the morphoprotein BolA from E. coli and its various homologues. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division [1]. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase [1]. BolA is also induced by stress during early stages of growth [1] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [2,1].

Literature references

  1. Santos JM, Freire P, Vicente M, Arraiano CM; , Mol Microbiol 1999;32:789-798.: The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth. PUBMED:10361282 EPMC:10361282

  2. Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR; , EMBO J 1989;8:3923-3931.: Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene. PUBMED:2684651 EPMC:2684651


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002634

This family consist of the morpho-protein BolA from Escherichia coli and its various homologues. In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division [ PUBMED:10361282 ]. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase [ PUBMED:10361282 ]. BolA is also induced by stress during early stages of growth [ PUBMED:10361282 ] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [ PUBMED:2684651 , PUBMED:10361282 ]. IbaG is a BolA homologue involved in acid resistance [ PUBMED:22534295 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(351)
Full
(10044)
Representative proteomes UniProt
(35588)
RP15
(1638)
RP35
(4738)
RP55
(9302)
RP75
(15544)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(351)
Full
(10044)
Representative proteomes UniProt
(35588)
RP15
(1638)
RP35
(4738)
RP55
(9302)
RP75
(15544)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(351)
Full
(10044)
Representative proteomes UniProt
(35588)
RP15
(1638)
RP35
(4738)
RP55
(9302)
RP75
(15544)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1996 (release 4.1)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A
Number in seed: 351
Number in full: 10044
Average length of the domain: 72.9 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 65.19 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.7 25.7
Trusted cut-off 25.7 25.7
Noise cut-off 25.6 25.6
Model length: 78
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BolA domain has been found. There are 27 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044UGS7 View 3D Structure Click here
A0A077Z054 View 3D Structure Click here
A0A077Z4M5 View 3D Structure Click here
A0A077ZFB4 View 3D Structure Click here
A0A0A2V0I0 View 3D Structure Click here
A0A0D2FD13 View 3D Structure Click here
A0A0D2G934 View 3D Structure Click here
A0A0H3GJ55 View 3D Structure Click here
A0A0H3GY24 View 3D Structure Click here
A0A0H5S9A4 View 3D Structure Click here
A0A0K0E188 View 3D Structure Click here
A0A0K0EHD7 View 3D Structure Click here
A0A0N4U231 View 3D Structure Click here
A0A0N4UDF9 View 3D Structure Click here
A0A0P0VAX3 View 3D Structure Click here
A0A0R0FV61 View 3D Structure Click here
A0A0R0IFE0 View 3D Structure Click here
A0A146MGS0 View 3D Structure Click here
A0A175W9H6 View 3D Structure Click here
A0A175WAU7 View 3D Structure Click here
A0A175WG09 View 3D Structure Click here
A0A1C1CE29 View 3D Structure Click here
A0A1C1CWS2 View 3D Structure Click here
A0A1D6HE81 View 3D Structure Click here
A0A1D8PRQ4 View 3D Structure Click here
A0A2K6WF68 View 3D Structure Click here
A0A3P7EA14 View 3D Structure Click here
A0A5K4F6M6 View 3D Structure Click here
A0A5K4F8R5 View 3D Structure Click here
A1Z933 View 3D Structure Click here
A4HZJ2 View 3D Structure Click here
A4I112 View 3D Structure Click here
B6SIB6 View 3D Structure Click here
C0NH45 View 3D Structure Click here
C0NVY3 View 3D Structure Click here
C1HE54 View 3D Structure Click here
C6T2B7 View 3D Structure Click here
C6TFI3 View 3D Structure Click here
D3ZT98 View 3D Structure Click here
D4A9P7 View 3D Structure Click here