Summary: BolA-like protein
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This is the Wikipedia entry entitled "BolA-like protein family". More...
BolA-like protein family Edit Wikipedia article
BolA | |||||||||
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![]() solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115 | |||||||||
Identifiers | |||||||||
Symbol | BolA | ||||||||
Pfam | PF01722 | ||||||||
InterPro | IPR002634 | ||||||||
SCOP2 | 1v9j / SCOPe / SUPFAM | ||||||||
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In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli and its various homologs. In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[1] The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase.[1] BolA is also induced by stress during early stages of growth [1] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[2][1]
References
- ^ a b c d Santos JM, Freire P, Vicente M, Arraiano CM (1999). "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. PMID 10361282.
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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
BolA-like protein Provide feedback
This family consist of the morphoprotein BolA from E. coli and its various homologues. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division [1]. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase [1]. BolA is also induced by stress during early stages of growth [1] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [2,1].
Literature references
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Santos JM, Freire P, Vicente M, Arraiano CM; , Mol Microbiol 1999;32:789-798.: The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth. PUBMED:10361282 EPMC:10361282
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Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR; , EMBO J 1989;8:3923-3931.: Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene. PUBMED:2684651 EPMC:2684651
Internal database links
SCOOP: | zf-C2H2 zf-H2C2_2 |
External database links
SCOP: | 1v9j |
This tab holds annotation information from the InterPro database.
InterPro entry IPR002634
This family consist of the morpho-protein BolA from Escherichia coli and its various homologues. In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division [ PUBMED:10361282 ]. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase [ PUBMED:10361282 ]. BolA is also induced by stress during early stages of growth [ PUBMED:10361282 ] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [ PUBMED:2684651 , PUBMED:10361282 ]. IbaG is a BolA homologue involved in acid resistance [ PUBMED:22534295 ].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Alignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (351) |
Full (10044) |
Representative proteomes | UniProt (35588) |
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RP15 (1638) |
RP35 (4738) |
RP55 (9302) |
RP75 (15544) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (351) |
Full (10044) |
Representative proteomes | UniProt (35588) |
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RP15 (1638) |
RP35 (4738) |
RP55 (9302) |
RP75 (15544) |
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Raw Stockholm | |||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Pfam-B_1996 (release 4.1) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Bashton M |
Number in seed: | 351 |
Number in full: | 10044 |
Average length of the domain: | 72.9 aa |
Average identity of full alignment: | 30 % |
Average coverage of the sequence by the domain: | 65.19 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 78 | ||||||||||||
Family (HMM) version: | 21 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BolA domain has been found. There are 27 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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AlphaFold Structure Predictions
The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.